Scribd Logo
Upload

Welcome to Scribd!

  • Slide 20

    Uploaded by

    api-3698533
    3 views1 page
    This document summarizes Baird's 1969 model of calculating total metabolic clearance rate (MCR_T) of testosterone by accounting for both hepatic and non-hepatic contributions. The model estimates MCR_T as the sum of hepatic blood flow rate multiplied by the hepatic extraction fraction and non-hepatic blood flow rate multiplied by the non-hepatic extraction fraction. For men, MCR_T was estimated to be 1100 L/day with 56.2% from the liver and 23.3% from other tissues. For women, MCR_T was estimated to be 600 L/day with 36.9% from the liver and 13.2% from other tissues.

    Original Description:

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This document summarizes Baird's 1969 model of calculating total metabolic clearance rate (MCR_T) of testosterone by accounting for both hepatic and non-hepatic contributions. The model estimates MCR_T as the sum of hepatic blood flow rate multiplied by the hepatic extraction fraction and non-hepatic blood flow rate multiplied by the non-hepatic extraction fraction. For men, MCR_T was estimated to be 1100 L/day with 56.2% from the liver and 23.3% from other tissues. For women, MCR_T was estimated to be 600 L/day with 36.9% from the liver and 13.2% from other tissues.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    3 views1 page

    Slide 20

    Uploaded by

    api-3698533
    This document summarizes Baird's 1969 model of calculating total metabolic clearance rate (MCR_T) of testosterone by accounting for both hepatic and non-hepatic contributions. The model estimates MCR_T as the sum of hepatic blood flow rate multiplied by the hepatic extraction fraction and non-hepatic blood flow rate multiplied by the non-hepatic extraction fraction. For men, MCR_T was estimated to be 1100 L/day with 56.2% from the liver and 23.3% from other tissues. For women, MCR_T was estimated to be 600 L/day with 36.9% from the liver and 13.2% from other tissues.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    Hepatic and Non-Hepatic Contributions to MCR_T:

    Modeling Baird’s Approach

    Baird (1969):
    MCR_T (L/day) = QHep x EFHep + QNon-Hep x EFNon-Hep
    EF_9 sec EF_2 sec
    Lit. Lit. Deduced
    (calc.) (calc.)

    Men *: 1100 = 1200 x 56.2% + 1836 x 23.3%


    Women **: 600 = 1000 x 36.9% + 1753 x 13.2%

    * Total T 500 ng/dL, Alb 4.5 g/dL, 30 nmol/L


    ** Total T 35 ng/dL, Alb 4.5 g/dL, 60 nmol/L

    Note:
    Cardiac Output – HPF ≈ 2900 L/day
    (EF_1 sec ⇒ QNon-Hep = 3100 L/day)

    You might also like