:

. (H5N1)

( Fowl plague ) A

(H5N1)

(H9N2)

H9N2
(H5N1)

(H7N7)

83

(H5N1)

Orthomyxoviridae

A A, B, C.

C B
.
Subtypes A

Neuraminidase (N) Haemagglutinine (H)

(N) (H)

(N) (H)

(H5N7). N7 H5

(H5N7 A (H4N9).

B A

 Wisconsin A H,N

H8N4
:A/turkey/Wisconsin/1/68/H8N4
A/Chicken/Scotland/59/H5N1

A/Turkey/Ontario/7732/66/H5N6

Low pathogenic form

Highly pathogenic form

A (H5N2)

Low (H7N1)

Highly pathogenic form

pathogenic form

H5N1
H5N3

H5N1 ,

:-

 1-

closed system

cariar
.
2-

3-

4.
5-

1-

2 :

3-

4-

.
. 5. 6 7-

. 8. 9 10-

) .

 H5

H9 H7
.
:-
. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10-

:
Low pathogenic form

Highly pathogenic form

Viremia

Endothelial cells

.
A Free-ranging

.

.

,
% .

Guinea fowl

.

. Sinusitis
A

14 A

:
( ELISA ) . -

. 2-

H & N . 3-

Tamiflu Oseltamivir

Nature

Nature H5N1

Relenza . Zanamivir

Neuraminidase inhibitors .Neuraminidase (N)

M2 inhibitors amantadine and

rimantadine
.

:
:

1-

. 2-

3-

. A

4-

pH)

).

5-

6-

H N

:-
.

.

.

.
:

Paramyxovirus 1-

PMV-1

120-300 2-

RNA 3-

Hemagglutinin .

 hemagglutination 4-

ha

: h1

hemolysin 5-

6-

7-

.
.

8-

..

9-

bpl 10 -

. 11-

doyle form 1-

velogenic viscerotropic n d > virus - vvnd

. 2- beach form

3- baudette form

4- hitchener form

. 5- lancaster

:-
:-
.

:
:-

mean death
time mdt .

icpi plindex

ivpi .

:-

:-

lentogenic ) (

.
mesogentic strian : (

velogenic strain (

:neurotropic velogenic ndv 1-

.
pneumotropic velogenic ndv 2-

:- 3:-

Vescerotropic velogenic ndv

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1.

2-

3-

4-

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6-

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1-

.
2-

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4-

:
peracute

...

1-

2-

proventriculus 3-

coecal
toncil

mesentry

5-

. crd
. 6-

7-

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1-

. 2-

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6-

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