PEARANDA, Sheilah Zarah E.

BSN206

Prof. Alma Trinidad Taragua, RN, MAN June 29, 2010

DISEASE PROCESS OF LIVER CIRRHOSIS

Etiologic Cause Functional liver tissue is destroyed by fibrous scar tissue
Functional liver tissue is destroyed by fibrous scar tissue

Diffuse fibrosis

Conversion of normal liver architecture into structurally abnormal nodules

Predisposing Factors y Alcoholism y Viral Hepatitis y Toxic reaction to drugs and chemicals y Biliary obstruction y Cardiac diseases

Disrupts flow in vascular channels and biliary duct system

Obstruction of biliary channels

Impaired uptake of bilirubin by the liver cells

Metabolism of proteins, carbohydrates, and fats

Resistance to flow in the portal venous system

Bile stasis

bilirubin in the blood

Hypoglycemia

Blood no longer flows freely through liver to IVC

bile in the GI

Jaundice No production of angiotensinogen by the liver Portal HPN Collateral channels connecting portal with systemic circulation opens

Lightcolored stool

Failure of RAAS to take place

Colloidal osmotic pressure Limits reabsorption of luid from the peritoneal cavity Development of portopulmonary shunts

Shunting of blood into the splenic vein

H2O and salt retention by the kidney

Ascites y Dull, aching pain in the right upper quadrant y Abdominal discomfort, dyspnea, insomnia

Blood bypass pulmonary capillaries

Splenomegaly

Anemia, Leukopenia, Thrombocytopeni a

Cyanosis

Liver necrosis

Liver failure

DEATH