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Genetic factors iv. Familial and racial factors 2) 1. 2. 4. 5. 6. 7. 8. Modifiable Risk Factor Environmental influences Obesity Physical inactivity Stressful life Infections (C. pneumoniae, Herpes virus, CMV) Homocystinuria Role of Alcohol
Initial inflammation endothelial dysfunction monocyte recruitment/differentiation to intima growth factors stimulate smooth muscle proliferation platelet activation/aggregation atheroma with thin fibrous cap, no more NO protecting vessels