SAFC® Total Support

We’ll give you a helping hand to

meet the REACH challenge

As your total supply chain partner, SAFC Supply Solutions can help you through
your REACH compliance needs.

Continuity of supply

By pre-registering our substances falling under the REACH regulations, you can count on SAFC
for a reliable supply of chemical raw materials. Several hundred compounds have already been
identified for pre-registration in order to help you continue an uninterrupted supply of starting
materials both in Europe and internationally.

SAFC's experience in forecasting and tracking quantities anticipates customers requirements

and will help you be REACH ready with the development materials you need throughout the
entire pipeline.

Widest range of substitute starting materials

SAFC will be your REACH compliant partner throughout the supply chain, whether you require
a new source, a dual source or new starting materials for substitution, giving you access to a
wide range of REACH compliant chemical products throughout your entire development and
manufacturing process.

When your needs evolve, quantities increase and lead to a change in the REACH status,
SAFC will help you select the best option allowed in the REACH program including:

• Pre-registration (by December 1, 2008)

• Late pre-registration (after December 2008)
• Formal registration (after June 2008)

Expertise in regulatory compliance

With a worldwide supply chain and global presence, SAFC is a leader in manufacturing, trading
and chemical regulation implementations. In addition to being within the first fine chemicals
suppliers to be fully REACH compliant, SAFC will offer you to take advantage of its expertise
concerning this implementation. Our experienced regulatory advisers will assist in providing
REACH compliance for your future supplies of raw materials and your own supply chain.

By choosing SAFC, you choose a long term and reliable partner who has knowledge, resources
and tools in place to provide REACH compliant starting material all along the development pipeline,
from scale up to commercial scale quantities.

www.safcsupplysolutions.com/reach
 SAFC® Total Support

About REACH

REACH (Registration, Evaluation, Authorization and restriction of Chemicals) is seen as the biggest
regulatory change that the European chemical market has ever faced and will lead to a novel model
of chemicals businesses in Europe.

The REACH implementation is a real challenge for companies who must register all substances
manufactured in or imported into the European Union in annual quantities of 1,000 KG and more
with the European CHemicals Agency (ECHA).

From European Commission evaluations, 30,000 existing substances will be affected by REACH and
should be registered by their suppliers in order to guarantee continuity of supply.

The REACH regulations primary objectives are to:

• Deliver benefits to human health and environment

• Reduction and rationalization of animal testing
• Maintain and enhance competitiveness and innovation in the European chemical industry

SAFC can guide you through the REACH challenge

SAFC has dedicated an entire team of experts and advisers to drive the REACH
implementation including:

• REACH project manager

• Data analysts
• External advisory expert

This team is supported by representatives from associated departments including:

management, purchasing and provisioning, quality assurance, IS, sales, marketing,
supply chain and compliance.

REACH Milestones
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Phase In period for June 1 June 1 Dec. 1 Jan. 1 Dec. 1 June 1 June 1
existing substances 2007 2008 2008 2009 2010 2013 2018

Late Pre-Registration
New Substances Registration

The above graph reflects information available in May 2008 from the ECHA and is subject to change by the ECHA or European Commission.
SAFC is not responsible for changes or amendments made by the ECHA or European Commission.

SAFC®, SAFC Supply Solutions® and Sigma-Aldrich® are registered trademarks

of Sigma-Aldrich Biotechnology L.P. and Sigma-Aldrich Co.

© 2008 SAFC All rights reserved.

KPC
04518-507240
0068 www.safcsupplysolutions.com/reach