;

"
$
%
&
'
(
)
*
+
,
/
0
1
2
3
4
5
6
7
8
9
:
;
<
=
>
?
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
U

R o o t
E n t r y

F
Microsoft Word-Dokument
MSWordDoc
Word.Document.8 9q

Oh +'0

@
H
`
l
x
!
.
@

Cubas -

.
[
B* OJ QJ
@ B
S t a n d
W W

+,D
l
CJ mH
A b s a
a r d s
8 N u m

Estvo
 @

. +, 0
l
P a d r o
sH KH PJ nH ^J aJ
t z c h r i f t a r t
1 z 0

>A @

Y

$ a$ 1$ *$ 7$ 5$ 3$ A$ 3
_H tH
B A
. .

OJ

QJ

^J

W W 8 N u m 2 z 0

OJ

QJ

^J

W W 8 N u m 3 z 0

OJ

QJ

^J

. ! .

W W 8 N u m 4 z 0

OJ

QJ

^J

. 1 .

W W 8 N u m 5 z 0

OJ

QJ

^J

. A .

W W 8 N u m 6 z 0

OJ

QJ

^J

. Q .

W W 8 N u m 7 z 0

OJ

QJ

^J

. a .

W W 8 N u m 8 z 0

OJ

QJ

^J

. q .

W W 8 N u m 9 z 0

OJ QJ ^J 0 0
W W 8 N u m 1 0 z 0

OJ QJ ^J 0 0
W W 8 N u m 1 1 z 0

OJ QJ ^J 0 0
W W 8 N u m 1 2 z 0

OJ QJ ^J 0 0
W W 8 N u m 1 3 z 0

OJ QJ ^J 0 0
W W 8 N u m 1 4 z 0

OJ QJ ^J 0 0
W W 8 N u m 1 5 z 0

OJ QJ ^J 0 0
W W 8 N u m 1 6 z 0

OJ QJ ^J 0 0
W W 8 N u m 1 7 z 0

OJ QJ ^J 0 0
W W 8 N u m 1 8 z 0

OJ QJ ^J 0 0
W W 8 N u m 1 9 z 0

OJ QJ ^J B ! B
S t a n d a r d s c h r
S t a n d a r d s c h r
S t a n d a r d s c h r
p a r g .
p a d r
a ,
M a r c a s
' x $
OJ QJ

A b s a t z i f t a r t
H 1 H
i f t a r t
J A J
i f t a r t 1
6 Q 6
o
, OJ QJ PJ ^J D D
CJ PJ ^J aJ 8 B
8

W W - A b s a t z W W - A b s a t z F o n t e
T t u l o

C o r p o
d e
t e x t o
(
x
" / "
L i s t a
)
^J @ @
L e g e n d a
q)>;KZQ UpK J 0(WxR/c=GhDi7\7?X-HT0.>
,x<lqK)Fh&Gq @

\DV%(l`Ge
` 8 4iELY I 7-Eu$rq=<GP+jV !
V'r-ikIXcS
}u{* EIiI)m MfT)5;{psKZhzu
W!>:#VR)|UL*m).FCS2ckj|7DsJ
i lWa,Pt2H
urg)*LXuySc c3_Yo!KpS(
5aaK**;?h
q< f^zj-vw3x.9R..^AJ<
^22NBd{!yS |tB3Y|fI-Qu-%dIrr!-&Ff);Xof;1Q~6na]

"?=\[ R\ZwpNW
-?m4BGR2=g{x
Q,V!X_?giuk80wdhI?%gQhS/)
m'
#m[H * S5co!d K!Uox#9_ t- 4h c%q
Z
`<]$YN}
wv~-L-gs[c3e9#?fBgg'Po3m(Xpv

0qE<

RlL=ME&u)3t
i}/t4)%YW9D K$L2=
+c=I;KqdBwA/c\&>v
g0-jjLx eF%
5IwxtYD$9' i>>h*6^T
Y{S3SsQPC_
/}ouJ,

G@cZg

&l-1
4| y j , 7 {y\ec"h!i7P6tQJ
J<;-7ZqU+B u P8 zI}DcKtR=
DCwj%}n'K|\tiM~QVwe@-oB

-1
?2T<aiB.k9B- QED
Kszv:P6r1s'eR9*
pA=3:

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8`

OJ

QJ

^J

^ `

OJ

QJ

^J

^ `

OJ

QJ

^J

^p`

OJ

QJ

^J

^
` OJ wHVIA'=X!Ht`q[y">i(-uN^B<SwKPk'Fi #. J{wq-K2/?Y-kl/a! g/K8;~]%kL8=ggP#J)1
MDx

Eu 0

^`

OJ

QJ

^J

^8`

OJ

QJ

^J

^ `

OJ

QJ

^J

^ `

OJ

QJ

^J

^p`

OJ

QJ

^J

`

OJ

QJ

^J

^@
` @
4}
?%~!R=}dn{

u+DK d,]=SV_6(*
}e{_-'W=o;Vc-o|CKXB"^'F<N vZq(
v@8EyKFJ,g=D/Kl
7De 9ok'qf?MzY}|Tl'~3
{fsvxCE]

^ `

OJ

QJ

^J

^ `

OJ

QJ

^J

^p`

OJ

QJ

^J

`

OJ

QJ

^J

^@
`
OJ QJ

@
^J

`

OJ

QJ

^J

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8`

OJ

QJ

^J

^ `

OJ

QJ

^J

^ `

OJ

QJ

^J

^p`

OJ

QJ

^J

`

OJ

^J

^@
` @
OJ QJ ^J

zV 09 >W -)3 41 1gI dD1,

2EDswpzm  z<k'Q<8 }
?=~6R=}_79M!# dW; Z( Y
}e{_!
'99zM(^{ts*M9 aZq(
v-jT\N/"3)< !t4[sK

^ `

OJ

QJ

^J

^p`

OJ

QJ

^J

^
p

`

OJ

QJ`q}L*"$%c

('~
W eC

4}vf9`-d7bC^4MDx>I8!afZa.OLL0v
d hr>|-Ig?(p{ka"hWLcRz *
gil mhMT~]%PZ&_+Pt&-Wi-'&%>HB|VQm_z'~Z
ho/S'[G`@y ^8L i vi_"2}~+R%7Ny)GCH_(IBIn;n3/AR+
%2-,!8\RB_2[~'o$Z)KP4?0bWFd R

2|Jc"e9)0JvX^my2.-?

>L?`@E-`qbIcal3AglP[W#QJ ^J

^@
`
OJ QJ

@
^J

`

OJ

QJ

^J

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8`

OJ

QJ

^J

^ `

OJ

QJ

^J

^ `

OJ

QJ

^J

^p`

OJ

QJ

^J

`

OJ

QJ

^J

^@
`
OJ QJ

@
^J

`

OJ

QJ

^J

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8` 8 OJ QJ ^J
-
{XkPD}eBSbE
& h)9
{EN,G<Q. x:&*YKG!s*5#
BkO L
7SLA#Aww(EkTaJ8/1| jUDfK. !

{u:#hfPoN%DrA
O/Gwj8kDDe9:-j05

^@
`
OJ QJ

@
^J

`

OJ

QJ

^J

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8` 8 OJ QJ ^J
-
:
V >3w<BNTzX%_uiY_q2 P]U yR"
ZYOp.gR"rI_T- m U7LYH@?#&

q_7;*[x%

|L* -

`

OJ

QJ

^J

^@
`
OJ QJ

@
^J

`

OJ

QJ

^J

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8`

OJ

QJ

^J

^ `

OJ

QJ

^J

^ `

37,)/Y+a~oo2V*#:(Avi_d

W1H$7g-Q3Hg8Dsu1;3yV\5Fbk"5p
]vAS,
/F@&v3y

QENLH
v+^J 4K 7!*` _G#z]-V-`P
>!*j% k
}AG2`rcp

/g

~j

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8` 8 OJ QJ ^J
-
~
\{Fm;'X@DYW8C>dVg03)Co%voyAt_pt0
WN7h*^X}wHG|\v1Yf(L-_l@ON_QE
oJ@;Vf5.1Pz0 _B):C$WTuql
yeXi/>6Y\73LYyNBt

9~-` @1zx-s&*#X@
B4 1O j1 O3H #L _1DLw
#dB!bYr=[X"P6.a?eo3-=b\`#~m[GCG]-)n=py5(>lqO&H
_F[l!0
_# f(Z{
G|jC|b

A|X"U
gc-

^ `

OJ

QJ

^J

^ `
OJ
dO#S[

QJ

t Z%qqh

%2zI?RBL
7#VOPTX }c+*AuORn;Wa2h|I
=U ?

J"

Jewlz^fPp'-PK<Ms

;T
g]
VV-rP_8:oI/];BMb

wHvz Z^

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8`

OJ

QJ

^J

^ `

OJ

QJ

^J

^ `

OJ

QJ

^J

^p`

OJ

QJ

^J

`

OJ

QJ

^J

^@
`
OJ QJ

@
^J

`

OJ

QJ

^J

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8`

OJ

QJ

^J

^ `

OJ

QJ

^J

^ `

OJ

QJ

^J

^p`

OJ

QJ

^J

`

OJ

QJ

^J

^@
`
OJ QJ

@
^J

`

OJ

QJ

^J

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8`

OJ

QJ

^J

^ `

OJ

QJ

^J

^ `

OJ

QJ

^J

^p`

OJ

QJ

^J

`

OJ

QJ

^J

^@
`
OJ QJ

@
^J

`

OJ

QJ

^J

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8`

OJ

QJ

^J

^ `

OJ

QJ

^J

^ `

OJ

QJ

^J

^p`

OJ

QJ

^J

`

OJ

QJ

^J

^@
`
OJ QJ

@
^J

`

OJ

QJ

^J

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8`

OJ

QJ

^J

^ `

OJ

QJ

^J

^ `

OJ

QJ

^J

^p`

OJ

QJ

^J

`

OJ

QJ

^J

^@
`
OJ QJ

@
^J

`

OJ

QJ

^J

^

`

OJ

QJ

^J

^`

OJ

QJ

^J

^8`

OJ

QJ

^J

^ `

OJ

QJ

^J

^ `

OJ

QJ

^J

^p`

OJ

QJ

^J

`

OJ

QJ

^J

^@
`
OJ QJ

@
^J

`

OJ

QJ

^J

^

`

OJ

QJ ^J

^@`

^`P

^``
`

^`

^`0

^` 

^0`

^`

^ ``

W W 8 N u m 1
W W
8 N u m 2
W W 8 N u m 3
W W 8 N u m 4
W W 8 N u m 5
W W 8 N u m 6
W W 8 N u m 7
W W 8 N u m 8
W W 8 N u m 9
W W 8 N u m 1 0
W W
8 N u m 1 1
W W 8 N u m 1 2
W W 8 N u m 1 3
W W 8 N u m 1 4
W W 8
N u m 1 5
W W 8 N u m 1 6
W W 8 N u m 1 7
W W 8 N u m 1 8
W W 8
N u m 1 9
!
! P
G
T i m e s
N e w
R o m a n
5
S y m b o l
3&
A r i a l
O&
L u c i d a
S a n s
U n i c o d e
5&
T a h o m a
5

S y m b o l
_
O p e n S y m b o l
A r i a l
U n i c o d e
M S
;
M S
M i n c h o
5
T a h o m a
5
T a h o m a
G
M S
M i n c h o
-3

f g

B
_

E&F

'

0
0

.J

Caolan80
2^

&

'

D
9

;7
7
&7

V
5

2
L

:4


7

D r o g a s
a n t i - m i c r o b i a n a s
R e s u m o
I I I
M i c r o b i o l o g i a
T o r t o r a
I n t r we:-}01}
K
<
6) 1h< B
#
!7P6a )tS_ -z,
kyXF*x4)}MI2@g\dam|1
GsHD

\Qs5e LQw~HirZk"NP$a +ax

Ev!2Lq:K&:]Z%@c4Y:+B,l1rNPUvj~Js;?

W;yj!

$[Q*TiDF,8skWj|T+$ lWA,PtA HZn u I Yjxu 0

he%b936 F!eSok5 k /*1
szOr mhzx|Xw3e1>frKR$tVx-X"wE\

 -RM"ZZ2<Fd~[0I6 ^Y#j3\R11I
b Fl I W A
4
%yS i b&n]NQ@<si;
=.Q]y5.4uQ=*q6mZv6,-'$

-\ !w-

;{Q&3+X 3]eJzVT4dcISODz Z <Z

M _; u 56+uy*^0MJ*

3.%K4ox-p> ]C@9N' d
4:nrQ
Y-uRm2Jc"Mg9WJB~>Ama^ht =
G6

P\, =?nW

/@i=I;1~ }@
}z
KA(2=+xD3M^f6fr qb=
w* _-jLxLEFAU
. LuA%="*| i>Lh
6;t=9@-=+ifF+6<l r-)Zb.B= u#,c

l-X|-~4-1tq:
-'04(C
#H!7P6<Qsg:W4^zt
&-Ce4t<8}z*}dc$x0=lS
F~o x&f Mec<=] }~VWh@
oNi
~$

>}>]0WG82Czq$DKzfvE2\]mp#_vL@D>
.l-\ ?^2 ;n t i - m i c r o b i a n a s
a f e t a m
m u i t o s
a l v o s
e m
u m a
c l u l a
p r o c a r i t i c a .
A s
i n f e c e s
c a u s a d a s
p o r
f u n g o s ,
p r o t o z o r i o s
e
h e l m i n t o s
s o
m a i s
d i f c e i s
d e
s e r e m
t r a t a d a s
p o r q u e
e s s e s
o r g a n i s m o s
p o s s u e m
c l u l a s
e u c a !$O@N<9
t`qk[-"-B!hi|,:VUvbJ G -NF
B # ){h G:*Q1^K2gNJJ]9j^:PkL_wW
-DR5`ye
0|
Hl a s
g r a m - p o s i t i v a s .
A s
d r o g a s
c o m
a m p l o
e s p e c t r o
d e
a t i v i d a d e
a f e t a m
u m
g r a n d e
n m e r o
d e
m i c r b i o s .
A s
d r o g a s
h i d r o f l i c a s
p e q u e n a s
p o d e m
a f e t a r
c l u l a s
g r a m - n e g a t i v a s .
O s
a g e n t e s
a n t i m i c r o b i a n Gl
=~6?=d{,, Q^juZh

0-{ N8IoZVo- X^C,"9;a?q(~v@|jIK C(**ni
*2dZT1Wp ZY |T U3'-w
74wlC}2ho g a
q u e
e s t
s e n d o
u s a d a
o u
q u a n d o
a
m i c r o b i o t a ,
n o r m a l m e n t e
r e s i s t e n t e ,
m u l t i p l i c a s e
e x c e s s i v a m e n t e .
A o

d e

d r o g a s

a n t i - m i c r o b i a n a s

D e
f o r m a
g e r a l ,
a
a o
d a s
d r o g a s
o c o r r e
t a n t o
m a t a n d o
d i r e t a m e n t e
o s
m i c r o r g a n i s m o s
( b a c t e r i c i d a )
q u a n t o
i n i b i n d o
s e u
c r e s c i m e n t o
( b a c t e r i o s t t i c a ) .
A l g u n s
a g e n t e s ,
c o m o
a
p e n i c i l i n a ,
i n i b e m
a
s n t e s e
d a
p a r e d e
c e l u l a r
d a
b a c t r i a .
O u t r o s
a g e n t e s ,
c o m o
o
c l o r a n f e n i c o l ,
a
e r i t r o m i c i n a ,
a s
t e t :~
_V8f .1 Ewgv1
I DXB2e=s)`x] mn-WYD
V=~6&=d {c,
QVv<Zh T
]:-w S2No Vo-
RX^C,"96-a?q(lv@Kr`IK#As
$@qjaucK<|{t i c a s .
A
r i f a m p i n a
e
a s
q u i n o l o n a s
i n i b e m
a
s n t e s e
d e
c i d o s
n u c l e i c o s .
O s
a g e n t e s P4M*C3%7cc
=

F'~
:TfZU|BmJKOabI@$D_I8!mfCN-c"@+ @p

"pE?k-)\&gP( i{c k?7oYp- 9 Ep

k'm
#Ta~]2%9ZE.X)b|,L&BY;6}vl_
0^R|H ':G

$qfi - m
ow3-x8;ZH4||H7Ny\Gw*H3AE J
Z".'kUDq.Z_8=rB7_\[
~kBoY-^+aH 9|v]=1ng" skve

S|6+e9W0#!Ri(Mh

6;7+ja
-)?

`E- 5c 2=r'YsRTs

p e n i c i l i n a s
n a t u r a i s
p r o d u z i d a s
p o r
P e n i c i l l i u m
s o
e f e t i v a s
c o n t r a
c o c o s
g r a m p o s i t i v o s
e
e s p i r o q u e t a s .
A s
p e n i c i l i n a s e s
( b e t a - l a c t a m a s e )
s o
e n z i m a s
b a c t e r i a n a s
q u e
d e s t r o e m
a s
p e n i c i l i n a s
n a t u r a i s .
A s
p e n i c i l i n a s
s e m i - s i n t t i c a s
s o
p r o d u z i d a s
e m
l a b o r a t r i o
p e l a
a d i o
d e
c a d e i a s
l a t e r a i s
n o
a n e l
b e t a - l a c t m i c o
p r o d u z i d o
p e l o
f u n g o .
A s
p e n i c i l i n a s
s e m i - s i n t t i c a s
s o
r e s i s t e n t e s
s
p e n i c i l i n a s e s
e
a p r e s e n t a m
u m
e s p e c t r o
xk1D{}elB_byy=JP0,X_COCZ$<`Q.h&x4
rEF^D }v /j%/4B0k.L
T
d!I1r 6
L =0<OWq zy

:DF*.n!

~
I[
s n
O
m
s o m
A
c
p a r

S#-
HMd4&<)$Jvq/khDDe9S-0Pim
a
t e s e
d a
p a r e d e
c e l u l a r .
o n o b a c t m i c o
a z t r e o n a m
a f e t a
e n t e
b a c t r i a s
g r a m - n e g a t i v a s .
e f a l o s p o r i n a
i n i b e
a
s n t e s e
d a
e d e
c ~Vhov 22F^ \o$

p8rZ2W4 t =}URK?'Sxk"%jZQ
"#l@BDLY'@c&kqO{b>V`>
7 a"g
$b a c i t r a c i n a ,
i n i b e m
a
s n t e s e
d a
p a r e d e
c e l u l a r
p r i n c i p a l m e n t e
e m
b a c t r i a s
g r a m - p o s i t i v a s .
A
v a n c o m i c i n a
i n i b e
a
s n t e s e
d a
p a r e d e
c e l u l a r
e
p o d e
s e r
u s a d a
p a r a
m a t a r
e s t a f i l o c o c o s
q u e
p r o d u z e m
p e n i c i l i n a s e .
A s
e s t r e p t o - g r a m i n a s
s o
Tfr)<*ndo%V^F:(Avi>dj>&K3l
Gfb
P]HDuCjO35\TJ 5]L2bs,RYy~,ES[x

qE/L:hv+?F?V=6+Am5BP$.:8`Pv>*%uk/Ir
FlT,S
~ V bSKd a
( I N H )
i n i b e
a
s n t e s e
d e
c i d o
m i c l i c o
n a s
m i c o b a c t r i a s .
A
I N H

a d m i n i s t r a d a
e m
c o n j u n t o
c o n
|wZMA7V=eq 28O@ay,tf_T<
).T):mG_5zI'wptfM[}*@<N_-t9j
N h>3A{Q7=t6EW

+2A

! )eR4(`9P/K7?YY;7@LYy<btyury
a
t u
C\y^6(&'#x
B4 X+m1p S IsSn
! !&qbt" '|! 8r={XAP6Aaa F&<6{k:jrqTj:)n=y5M
>2!/
1gI 6r!'_Ltf(7
{nG|C<hzi=#2X S"bqp t o - g r a m i n a s
i n i b e m
a
s n t e s e
p r o t e i c a
n o s
r i b o s s o m o s
7 0 S Te [S~[e"V[@
*:r`

.PPX6d}B*.y<

}

0)`_4}mqH s

R1U' ZlJtC

izek):4z$u,[UVK# RT
]h -Vv;0Wj-/HEXDLwhaZ:
m e m b r a n a s
p l a s m t i c a s .
I n i b i d o r e s
d a
s n t e s e
n u c l e i c o s
( D N A / R N A )
A
e
t
A
i
t
u

r i f a

u s
u b e r c
s
q u i
n i b e m
r a t a m
r i n r

m
a
u
n

i
d
l
o
a
e n
i o

c i n a
i n i b
a
n o
t r a t
o s e .
l o n a s
e
a
D N A
g i r a
t o
d e
i n f
.

d e

c i d o s

e
a
s n t e s e
a m e n t o
d a

O
a
e
s
O
c
u
s
A
s
O
u
A
d
u
d
f

s
s
o m p
l i
a s
o m p
i i d

u
e
c
s
e
r

l
t
o
o
t
o

f
i
.
c
i
f

o n a m i d a s
i n i b e m
t i v a m e n t e
a
s n t e s e

c i d o

i a o
T M P - S M Z
i n i b e m
t i v a m e n t e
a
s n t e s e
d o
l i c o .

c i d o

a n t i - f n g i c a s

s
n
s

s
o
s
i
s

n o s
i c i
d a
i c i
e
n t e
o
t
a s
o c a
d a
a n
m e t
f u l
c e l
i n c
e

m
i
s
e
u

i
e
i
n
i
s

e
r
s
g
s

n
i c
i n
e
t e
i e o
o
p r
e c
.

D r o g a s

s n t e s e

d e

D r o g a s
p o l
f o - t
t e r
o
f u
a z
m
a
a d o s
s t m
e q u
n t e s
a g e n
a n t
g r i s
v i s
a d a
i n f
n g o s

m R N A

s
f l o r - q u i n o l o n a s
s e
p a r a
o
e c e s
n o
t r a t o

I n i b i d o r e s
c o m p e t i t i v o s
d a
d e
m e t a b l i t o s
e s s e n c i a i s
A
c
f
A
c
d

d e

,
n a
m
d a
a s
s e
r a
e
n d
p a
t i
a b
v i
u l
i p
s

c o
B
e m
s .
a
d
t a
c u
i n
r e
- f
l
n a
a r
a l
d a

m o
a
n i s t a t i n a
e
a
,
c o m b i n a m - s e
c o m
b r a n a
p l a s m t i c a
e
l
e
m
t
a
d

i l
e
e n
n
s
e
n g
t o
i n
e u
m e n
p e

a
s
t
e
i
c
i
t
c
t
l

m
t
o
a
n
e
c
d
e
a
e
e

i n a
e r
d e
s .
t e r
l u l
o
f
a
c
r f e
r i
n o
c a

s
i n t e r f e r e m
i s
e
s o
m i c o s e s
f
a
l
i
r
t

e
r
u
t
e
i
t
u s

r e
f
c i
o s
c
c a
r a
a d

t
i
o

n
o
n
m
e
t a
a s

c
g
s
a

o
i
i
.
a

m e
p

m
a
c a .
n a

n t o
o r

a n t i - v i r a i s

O s
a n l o g o s
d e
n u c l e o s d e o s
e
n u c l e o t d e o s
c o m o
o
a c i c l o v i r ,
o
A Z T ,
o
d d I
e
o
d d C
i n i b e m
a
s n t e s e

d
O
u
i
O
s
O
p
c

e
s
s
n
u

s
r

D
i
a d
f e
t r
o
i
o p
l u

N
n
o
c
o
a
n
a
l

A
e
e
i b i d o
s
p a r
e s
s
a l v
f i x a
t e r f e
g a o
a s .

r
a
p
o

R N
e s
t
o r
s
o
o n
d o

A .
d
r a
H
d a
e
s
s

e
e n
t a r
I V .
s
d r
a
d
a l f a
v r u

z i m a s
v i r a i s
a
g r i p e
e
o g a
e c a
i n
s
p

s o

s
a n t i - v i r a i s
p s i d a o .
i b e m
a
a r a
n o v a s

D r o g a s
a n t i - p r o t o z o r i o s
h e l m n t i c a s

A
d
o
t
p
A
n
p
O
m
O
i
n

,
a
t a m i d i n a
e
d o s
n o
u s a d a s
p o r

c
i i
m
r a
r o
s
i c
r a
m
i c
p
v e
e m

l
o
e
t
t
d
l
z
e
r
a
r
a

o
d
t
a
o
r
o
i
b
o
m
m
t

r
o
r
m
z
o
s
q
e
t
o
e
e

o
o
e
o
g
a
u
n

a
c
l

q
h
n
n

a
m
a
d
b
t
t
m

u
i
i
t
r
s
i
n
a
u
o
i
i

i
d
d
o
i
d
t
z
l
n
n

n a ,
r o x i
a z o l
d e
o s .
a n t i
a ,
o
e l
e
o l
d
o s .
d e
p
a
p a
t o s

T e s t e s
p a r a
t e r a p i a
E
d
t
c
E
s
p

s
e
e
o
s
u
r

s
t
r
m
s
s
e
d

e
e
a
b
e
c
v
r

O s
N
T
b
a
i
t
c
D
c
d

e
e
a
g
m
e
u
e
r
i

s
s
c
a
p
r
l
p
e
s

s
r
p
a
s
e
i
o

t e
m i n
u t
t e r
t e
p t i
s t a
g a .

s t e
a r
i c o
u m
s t e
b i l
o u

m t o d o s
s
t
t
r
r
a
t
o
s
c

e
e

,
e
p
u
i
c
o

r
g

r
s
i

t
d
i
e
n
u
a

e s t e
e
K i
a s

d i s
a d o s
t i c o
.
d a
i
m e n t o

d e n

a
q u
s
i n

q
i

u i n a c r i n a
n a ,
a
p e n
o
u t i l i z a
e c e s
c a

- h e l m
m e b e n
a
p i p
e s o r g a

n
d
e
n

s
a l
o
a t
s
a d
u a

d e
,
r b
i
c o
c
s

t
y
n
s
o
s

i
z
a
z

c a s
i n c l u e m
o l ,
o
z i n a .
a
o s

i r a n t e l
e
a
r a l i s a m
o s
i n t e s t i n a i s .

o r i e n t a r
s
q u

p
s
i d
q

t
a
r
i

a n t i -

u s
o
a
m a i
g e n
o
e m
e
n
n d o

a
g
s
o
p
o
s

a
d o s
e n t
a p
e s
r e g
p o
u r g

q u m i o p a
q
o p
e c
d o
e
r

r
u
r

s
s
e

a
m i o
i a d o
f i c o
q u a
e r
s i s t

h e c
m a
m
u
f i
q u
o s t

i
c
m
l

d o
u l t
m e
t r o
m i o
s
n

e
r
p
a
d
e

p a r a
.
n d o
a
n c i a

d i f u s o
a m b
- B a u
o c u l
d e
m
a g
o
s

m
e
a
p
e
o

r
d
a
n
b

c
,
a
p
t
r

o n
u
e
e l
e s
e p

c o m o
u r a
d e
i o
d e
a

n c u b a o ,
a
a u s n c i a
d e
m i c r o b i a n o
a o
r e d o r
d o
o m i n a d a
z o n a
d e
i n i b i o .

O
q
r
d
s
r
A
c
e
p

d
a
f
t
n
s
C
o n
v i
o d
u
e
e
e
e

i
n
e
e
s
i
I
c
t
e

d
r
r

s
M
e
a

m
o

m
v
t

e t
c
n c
i n
e l
e n
r e
n t r
r
o
s e r

T e s t e s
c u l t u r a
E
m
l
c
t
A
q
b
b

m
i

o
e

c
q
n
r
m
u
a c
a c

u
r
u
c
a
e
m
t
t

m
o
i
e
p
n
i

r
d
n

o
o
r
r

t
g
o
t
u
r
i
i

r
o
i
a
,
t
p
a

o
d a
m p a r
a
p a
r
s e
i n t
e

r e s e
o
c r e s
e s t i

d e
e t e
a n i
c o
r a
t i c
c o
t e r
a

c i d

s
n

o
n
a

d
m
t
e
.
c
p
d

s t
t r u
d o
g a
a s
t i o
d i t
n c
i t i
o s o
s t
s o
t r a
i a d

e
m

O
r i
c o l a
( e . g
p r e c

s
t
.
i

n
u
n

t
t
o
n

d o s

n c i
i
i m
n o
m e t
s - a
a r i
i a
d a
n s .
n c i
d i s
e
a s .

S e g u r a n a

d
o m

g a
i
.
m
o g
t o
u s

e
d i l u i
o

c u l
e n d o
d i
s
d o
a g

R e s i s t n c i a
r e s i
a
d e s
r o g a ,
a
d r o
u d a n
o s
s
h e r e
e s i s t
r a n s m
r a n s p
r e s i
e l o
u
o n c e n
p r o p r

n a
c
o ,
o r
e d
g a
a
d r
e n
a

d i l u i o

E f e t i v i d a d e
t e r p i c o s

A
d
d
d
m
n
A
r
t
t
A
p
c
a

z o
a d o
d r
o
e r m
d r o
n t a
d a
c i m
m a d

s
a
o
p
s
a
l
e
a
p

e
e
b
v
d
o

p
e
d
u

o
a
d
r

r
i
m
i

a
c
i
m

t
f
e

e
u
u
n i
r i

i
m
s
s
o

n i b i o ,
a
t a b e l a
a d o
p a r a
m o

o u

e n o
a
c
m i
a n d

r
a p a z
d e
c r o b i a n o
e
o
o
t e s t e
E .

e m

c a l d o

i
e
n

d e

o
e m
c a l d o ,
o
v a d o
e m
m e i o
r e n t e s
t e
q u m i o -

o
d o
a g e n t e
o
q u e
m a t a
a
n a d a
c o n c e n t r a o
a
( C B M ) .

a g e n t e s

q u m i o -

d r o g a s
o d e
n z i m
i m e n
s t
l i c a
.
d e
d
r o g a
p l a

t
i
s

e r
c o
t i c a
o
d a
o - a l v
o u
c

n
d
p
o
e

s e q u
e
u m
e n e t
o u
l u l a

e
f a t o r e s
s
(
R
)

s m d e o s
e

a
r
d
r

n c i a
a o
e
e s

d e

a
p o d e
s e r
m i n i m i z a d a
c r i m i n a d o
d e
d r o g a s
e m
s
e
d o s a g e n s

d o s

a n t i b i t i c o s

c o
( e . g . ,
o s
e f e i t o
e r a i s )
v e r s u s
o
b e n
,
a
c u r a
d e
u m a
i n f
s a m
s e r
a v a l i a d o s
a

s
e f c i o
e c o )
n t e s
d o

u s o

d o

a n t i b i t i c o .

E f e i t o s
A
s
e
s
A
a
a
q

l
i
f
o
l
n
m
u

g
n
e
z
g
t
b
e

u
e
t
i
u
a
a

m
r
i
n
m
g
s
q

a
g
v
h
a

a
a
s
n
t
u a

d a

c o
s t i
s
e
s .
c o
i c a
o r n
n d o

c o m b i n a o

d e

d r o g a s

m b i n a e s
d e
d r o g a s
c a s ;
e l a s
s o
m a i s
m
c o m b i n a o
d o
q u e
m b i
s ;
a m a d

O
f u t u r o
d o s
t e r p i c o s

n
q
s
m

a e s
d e
d r o g a
u a n d o
c o m b i n a d
e
m e n o s
e f e t i v
i n i s t r a d a s
s o z

a g e n t e s

s o
q u a n d o

s
s o
a s ,
a s
d o
i n h a s .

q u m i o -

M u i t a s
d o e n a s
c a u s a d a s
p o r
b a c t r i a s ,
p r e v i a m e n t e
t r a t v e i s
c o m
a n t i b i t i c o s ,
t o r n a r a m - s e
r e s i s t e n t e s
a
e l e s .
C o m p o s t o s
q u m i c o s
p r o d u z i d o s
p o r
p l a n t a s
e
a n i m a i s
e s t o
f o r n e c e n d o
n o v o s
a g e n t e s
a n t i - m i c r o b i a n o >
WhKQU]ykgp]g1tWgTSRq/-cWhLi^?T tH
q-P Cx}qK)!h&Gq

 \ $*V% (
y`g&k1k18 { Nl2 8 -5

Eurv=pGALjieRV!\"XHS.7uA`k[)IJ6ymO_#p8 jp KZ hI|u
uk-6Z}X
`}{U.$
)pC\p c
7hDsJxiL>aE923) S-r'c*Xy ]c
vH>bY
+!epS(
5aa *
~zO3m zfX3e1fuKR
vt3x-9R-EQ

N3M"Z22NFd{v[I6s{<Y|#jF\R^Ik}\}!-&Fli
& 4
`i>Qy6ia&nmN0@
<SiT R\ZQx] y 5A uQX
-6m4vM-$h5t 
Q&V+X_30efJz?Tx4dcI?*D

 ZgS/)m,;b56Gu*^0.*k3

D.Zox- O]6

@ PN' {
-
4hl~URQ Yh9R

|rJ"e7k>Jd~X}AMqc3D  6y~23
O Lsn2*JA6K;.}}
{

 qk2<DR^/m9
3q`b\w
U0ojjLx -]F!U

pLL)%&UFiZzh*P5CW=(i~F6
- 6*-J
Kbur&J%&ja0*I_0Q4(Vc#h!i7
P6aQJ :>Y 7Zt
U-C 4ct P8 zI}DcKxB=
>}}~~ggyzg"?@c= LyVB"@-kN> ~
e$p>}-e40#dub8YC- QODVKsnz*]33p. R7?`
DLK.
-=?~2o

$ a$
$ a$
&
F
$ a$
$ a$
$ a$
$ a$
$ a$
&
F
$ a$
$ a$
$ a$
$ a$
$ a$
$ a$
$ a$
$ a$
$ a$
@'x<X !
HtDqy *B`L

|\GfX UvvZJXGr-'QF.p #. Jk)hGU_K{4]E?k2eg!JJ8;*~]%kEL3f3 -)z1G`yxEu0

$

$ a$
$ a$
$ a$
&
F
$ a$
$ a$
$ a$
$ a$
$ a$
&
F
$ a$
$ a$
$ a$

"
 b
"
6
l- & v
d! l# $ d% f% h% % % & 4' }
?=~6=}n{

,dQ;Q Zh(
}e{_'W=o;Vof-fr9^2C,"9Zq(
v@IiKw.1(*K{nE2D/91!'fZzY|Tl'~3w
{W
Tv7ZC]@:

$ a$
$ a$
&
F
$ a$
$ a$
$ a$
$ a$
$ a$
&
F
$ a$
$ a$
$ a$
8' p' r' ' ' ' ^( `( ( ) )
) N* P* * r+ t+ v+ +

$ a$
$ a$
$ a$
&
F
$ a$
$ a$
$ a$
$ a$
$ a$
&
F
$ a$
$ a$
$ a$
$ a$
$ a$
&
F
$ a$
$ a$
$ a$
+ + , . . / / / / / 0 n1 1 2 2 2 2 2
4 4 "5

":>Vf3.1, {11gIdD12E
Ts)sx}0f_zmnmW< 4 }
=~6R=}dn{,ipdQ;Zh( Y
`}e{_'W=o;Vo%lYr ]g,!20aZr+lvCIc
m(:pn@qjvK,EJa$
$ a$
$ a$
&
F
$ a$
a$
"5 5 5 5

.8 08 9 :
<
P[M*"3%

T=

V=

('~


W=_z4|6m?*OaCI4MDx
>I8!mf!mc_C[@ vAP

dE?k-qIg?(pb {
k?f7 eY -XE`'ik mhMT]%PZ&O+$o|A
-&#Z8=Y~7l_z3ZWB?/2/[GjPzA|

$ a t

Q- 8ZY |zD7Mz*OIn_nH-I~"-

hR*D-Y

| 8\vfW2[u^'l

\ 1D + 8U\'|i]^YnzhO

Dem

2|
cae59t B=>7]
h6X-a
qL?`@E`qbYca2Z=
uxg]RT

$
$ a$
$ a$
&
F
$ a$
$ a$
$ a$
$ a$
&
F
$ a$
$ a$
$ a$
$ a$
&
F
$ a$
D D E F F
F F F G H (J *J ,J .J

$ a

$ a$
$ a$

$ a$

$ a$

$ a$
$ a$
$ a$
&
F
$ a$
$ a$
$ a$
$ a$
$ a$
-yPG+~A B_a|!y
'O{6BU=k~- < X9-GxO*Fv^!v/K4#
BkO L
7
d!+ArwX
! T0_O8q{z

UDfK. !

{u:#- aI[x% Mt
CO)G>vj/kDDe9:-j0=)
:
V 2 3\o$c`8X; P]U yR"ZI6xHKR%
tZQ-"
lB7LYH@?#&

qbW5`b>*+y7o

" *

E n t r y

R o o t

F
@
%cYYeao%V*#:(Avi_d-WKFlb
"fpP3oz8Dsu1;3yV\5Jb5]<2 sAR*
~

E& 7

QENLH
v+^F4tIj+
- B#$]0V R`h*j%kLIr
Flt,:
~gV
SS~1 T a b l e


a r y I n f o r m a t i o n
#
t i o n
t

_<
S u m m
(

W o r d D o c u m e n t

2^
D o c u m e n t S u m m a r y I n f o r m a
8