Mucoadhesive Force Measurement Adhesion was reported to be effected by hydration.

Hydration of the mucoadhesive polymer is essential to initiate the mucoadhesive bonding process. In case of tablets applied in the dehydrated state, which is most convenient, it is essential that sufficient water is available so that rapid hydration takes place, and a flexible rubbery state occurs. The capillary force arises when water from the space between the mucosa and the polymer was taken up by a dry system. Once the bond is formed, reduction in the rate of swelling due to water uptake from the tissue surface may only prolong the association of the tablet with the mucosa. Removal of water from the underlying mucosa layer by the hydrating polymer may increase the cohesive forces of mucus; this plays a vital role in the establishment of an effective mucoadhesive bond. Mucoadhesive force measurement of tables was done by modifying balance method. The right pan was replaced with a glass beaker container and on the left side beaker with a copper wire. Teflon block of 1.5 cm diameter and 3 cm height was adhered strongly with the glass beaker. The two sides were then adjusted, so that the left hand side was exactly 5 gms heavier than the right. Stick the stomach on the teflon block with help of the cynoacrylate glue and fill the beaker with acidic buffer till the tissue remains in a moist condition. Stick the tablet to beaker and put on the tissue for a 15 minute. After 15 minute add water slowly in to right beaker until the tablet detaches. Weight the water required for the tablet detachment. Calculate Actual weight for detachment and force of adhesion in dyne by following equation.

Force of adhesion (N) = Bioadhesive strength 9.81 100s Bond strength (N/m2) = Force adhesion (N) Surface area of tablet (m2)