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Pathophysiology

Non predisposing Factors

Predisposing factors

Immunocompromised Environment Prolonged hospitalization

Age Male

INVATION OF BACTERIA

Bacteria Goes to circulation

Inflammatory response

Release of exogenous pyrogens

Body release antiInflammatory mediators

Increase WBC

Vascular response

Release of endogenous pyrogens

Redness and heat

Reset of hypothalamic Thermostat

Fever

Blood vessels constrict preventing the loss of body heat

Chills

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