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fs57 \bullet }
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\plain\par
\pard\pard\sl-767 \li540 \ri81 \expndtw-11 \f10 \fs64 formationortopreventaclotthathas
rmed
\plain\par
\pard\pard\sl-768 \li540 \ri7722 \expndtw-18 \f10 \fs64 fromenlarging.
\par
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006 \expndtw-20 {\cf47 \f0\fs57 \bullet }
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\plain\par
\pard\pard\sl-765 \li540 \ri2380 \expndtw-9 \f10 \fs64 actionofclottingfactorsorplate
lets.
\par
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\plain\par
\pard\pard\sl-767 \li963 \ri6291 \expndtw-16 \f10 \fs64 categories:
\plain\par
\pard\pard\sl-200\fs20\par \par \pard\sl-526 \li4 \ri23 \expndtw-47 \f10 \fs38 \
cf47 1)
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\plain\par
\pard\pard\sl-200\fs20\par \par \pard\sl-527 \li4 \ri2650 \expndtw-47 \f10 \fs38
\cf47 2)
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\plain\par
\pard\pard\sl-200\fs20\par \par \pard\sl-528 \li4 \ri4728 \expndtw-47 \f10 \fs38
\cf47 3)
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ar \par \pard\sl-363 \li9232 \ri1645 \expndtw3 {\f0\fs54 \bullet }
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\fs57 \bullet }
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\plain\par
\pard\pard\sl-767 \li540 \ri7075 \expndtw-15 \f10 \fs64 bloodtoformclots.
\par
\plain\tx538 \tab \expndtw-6 \f10 \fs64 Althoughbloodclottingisessentialtoprevent
\plain\par
\pard\pard\sl-768 \li540 \ri1136 \expndtw-14 \f10 \fs64 >>>>>seriousbleedinginthecaseo
fskin
\plain\par
\pard\pard\sl-765 \li540 \ri649 \expndtw-33 \f10 \fs64 cuts,<><><><><><><clotsinsid
etheblood
\plain\par
\pard\pard\sl-768 \li540 \ri6 \expndtw-6 \f10 \fs64 vesselsblocktheflowofbloodtomajor
ans
\plain\par
\pard\pard\sl-767 \li540 \ri2530 \expndtw-4 \f10 \fs64 andcauseheartattacksandstrokes
.
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\pard\pard\sl-200\fs20\par \par \pard\sl-421 \li11092 \ri2419 \expndtw3 {\f0\fs5

4 \bullet }
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fs57 \bullet }
\plain\tx538 \tab \expndtw-4 \f10 \fs64 Althoughthesedrugsaresometimes
\plain\par
\pard\pard\sl-767 \li544 \ri954 \expndtw-9 \f10 \fs64 calledbloodthinners,theydonot
\plain\par
\pard\pard\sl-766 \li544 \ri3672 \expndtw-13 \f10 \fs64 actuallythintheblood.
\par
ar \par \par \par \par \par \par \par \par \par \par \par \pard\sl-379 \li9232 \
ri1555 \expndtw3 \f10 \fs36 5

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2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
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51400514514005145140051451400514514005145140051451400514514005145140051451400514
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51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
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51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145007f307ff071
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}}}
fs57 \bullet }
\plain\tx538 \tab \expndtw-5 \f10 \fs64 Thistypeofmedicationwillnotdissolveclots
\plain\par
\pard\pard\sl-767 \li540 \ri295 \expndtw-9 \f10 \fs64 thatalreadyhaveformed,althought
hedrug
\plain\par
\pard\pard\sl-768 \li540 \ri1855 \expndtw-7 \f10 \fs64 stopsanexistingclotfromworseni
ng.
\par

\plain\tx538 \tab \expndtw-8 \f10 \fs64 However,anothertypeofdrug,usedin
\plain\par
\pard\pard\sl-765 \li540 \ri249 \expndtw-14 \b \f10 \fs64 thrombolytictherapy\b0
,willdissolveexisting
\plain\par
\pard\pard\sl-768 \li540 \ri10265 \expndtw-31 \f10 \fs64 clots.
\par
\plain\pard\sl-200\fs20\par \par \par \par \par \par \pard\sl-389 \li11092 \ri19
33 \expndtw3 \f10 \fs36 6
\par
{\shp
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
b451457d59e785145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145007f307ff071
ff001a00729dc338c738a5a4000e94b4005145140051451400514514005145140051451400514514
}}}
fs57 \bullet }
\plain\tx538 \tab
\plain\par
\pard\pard\sl-767
tvalve
\plain\par
\pard\pard\sl-768
oranother
\plain\par
\pard\pard\sl-767
theartattack.
\expndtw-8 \f10 \fs64 theymaybegiventopreventbloodclotsfrom

\li540 \ri26 \expndtw-9 \f10 \fs64 formingafterthereplacementofahear
\li540 \ri752 \expndtw-12 \f10 \fs64 ortoreducetheriskofa\b stroke\b

\li540 \ri2194 \expndtw-19 \b \f10 \fs64 heartattack\b0 afterafirs
\par
ar \par \par \par \par \par \par \par \pard\sl-411 \li11092 \ri2113 \expndtw3 \f
10 \fs36 7
\par
{\shp
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
b451457d59e785145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
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}}}

\fs57 \bullet }
\plain\tx538 \tab \expndtw-5 \f10 \fs64 Theyarealsousedtoreducethe
\plain\par
\pard\pard\sl-767 \li544 \ri29 \expndtw-8 \f10 \fs64 chanceofbloodclotsformingduring
\plain\par
\pard\pard\sl-766 \li544 \ri314 \expndtw-6 \f10 \fs64 openheartsurgeryorheartbypass
\plain\par
\pard\pard\sl-767 \li544 \ri7349 \expndtw-24 \f10 \fs64 surgery.
\par
ar \par \par \par \par \par \par \par \pard\sl-411 \li9232 \ri1429 \expndtw3 \f1
0 \fs36 8
\par
{\shp
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
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05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
b451457d59e785145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
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}}}

}}\margt-40\margb60\margr660\margl140
\plain\pard\sl-200\fs20\par \pard\sl-553 \li1 \ri815 \expndtw-20 {\cf47 \f0\fs57
\bullet }
\plain\tx538 \tab \expndtw-4 \f10 \fs64 Lowdosesofthesedrugsmaybegivento
\plain\par
\pard\pard\sl-768 \li540 \ri145 \expndtw-7 \f10 \fs64 preventbloodclotsinpatientswhomu
ststay
\plain\par
\pard\pard\sl-767 \li540 \ri853 \expndtw-10 \f10 \fs64 inbedforalongtimeaftercertaint
sof
\plain\par
\pard\pard\sl-766 \li540 \ri9672 \expndtw-24 \f10 \fs64 surgery.
\par
ard\sl-583 \li1 \ri991 \expndtw-20 {\cf47 \f0\fs57 \bullet }
\plain\tx538 \tab \expndtw-2 \f10 \fs64 Becauseanticoagulantsaffecttheblood's
\plain\par
\pard\pard\sl-766 \li540 \ri944 \expndtw-8 \f10 \fs64 abilitytoclot,theycanincreasethe
iskof
\plain\par
\pard\pard\sl-767 \li540 \ri1807 \expndtw-2 \f10 \fs64 severebleedingandheavybloodlos
s.
\par
\plain\tx538 \tab \expndtw-6 \f10 \fs64 Itisthusessentialtotakethesedrugsexactly
\plain\par
\pard\pard\sl-766 \li540 \ri463 \expndtw-2 \f10 \fs64 asdirectedafterallnecessaryinve
stigations
\plain\par
\pard\pard\sl-449 \li11092 \ri2077 \expndtw3 \f10 \fs36 9
\par
\pard\sl-80\fs8\sect\sectd\sbkpage\margtsxn-120\pard
{\shp
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010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
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51450014514500145145001451450014514500145145001451450014514500145145001451450014
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51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145007f307ff071
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}}}
\plain\pard\sl-812 \li1814 \ri120 \expndtw-8 \f10 \fs64 \cf46 Anticoagulantdrugsfa
llintothreegroups:
\par
\li1 \ri683 \expndtw-20 {\cf47 \f0\fs57 \bullet }
\plain\tx538 \tab \expndtw-7 \f10 \fs64 Inhibitorsofclottingfactorsynthesis.These
\plain\par
\pard\pard\sl-767 \li540 \ri20 \expndtw-8 \f10 \fs64 anticoagulantsinhibittheproduc
tionofcertain
\plain\par
\pard\pard\sl-768 \li540 \ri5067 \expndtw-13 \f10 \fs64 clottingfactorsintheliver.
\par
\plain\tx538 \tab \expndtw-7 \f10 \fs64 Oneexampleiswarfarin(brandname:
\plain\par
\pard\pard\sl-765 \li540 \ri8874 \expndtw-20 \f10 \fs64 coumadin).
\par
\li11092 \ri2024 \expndtw-44 \f10 \fs36 10
\par
{\shp
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\plain\pard\sl-200\fs20\par \par \pard\sl-532 \li4 \ri1961 \expndtw-20 {\cf47 \f
0\fs57 \bullet }
\plain\tx538 \tab \expndtw-14 \f10 \fs64 Inhibitorsofthrombin.Thrombin
\plain\par
\pard\pard\sl-767 \li544 \ri9 \expndtw-11 \f10 \fs64 inhibitorsinterferewithbloodclo
ttingby
\plain\par
\pard\pard\sl-766 \li544 \ri1893 \expndtw-12 \f10 \fs64 blockingtheactivityofthrombi
n.
\par
\plain\tx538 \tab \expndtw-7 \f10 \fs64 Theyincludeheparin,lepirudin
\plain\par
\pard\pard\sl-767 \li544 \ri7231 \expndtw-19 \f10 \fs64 (Refludan).
\par
\li9232 \ri2060 \expndtw-44 \f10 \fs36 11
\par
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\plain\tx538 \tab \expndtw-6 \f10 \fs64 Thesedrugsinteractwithplatelets,whichisa
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\pard\pard\sl-767 \li540 \ri1362 \expndtw-9 \f10 \fs64 typeofbloodcell,toblockplatelet

sfrom
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\pard\pard\sl-766 \li540 \ri3891 \expndtw-11 \f10 \fs64 aggregatingintoharmfulclots
.
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id),
\plain\par
\pard\pard\sl-767 \li540 \ri76 \expndtw-7 \f10 \fs64 clopidogrel(Plavix),tirofiban(
Aggrastat),and
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\pard\pard\sl-766 \li540 \ri5936 \expndtw-18 \f10 \fs64 eptifibatide(Integrilin).
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98 \expndtw-44 \f10 \fs36 12
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\plain\pard\sl-1076 \li14 \ri2083 \expndtw-33 \b \f10 \fs88 \cf46 Recommendeddosa
ge
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l-556 \li64 \ri22 \expndtw-20 {\cf47 \f0\fs57 \bullet }
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e
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\pard\pard\sl-767 \li604 \ri7213 \expndtw-14 \f10 \fs64 prescribed.
\par
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\plain\tx598 \tab \expndtw-5 \f10 \fs64 Doseisadjustedaftercheckingthe
\plain\par
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2 \expndtw-44 \f10 \fs36 13
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}}}
\fs57 \bullet }
\plain\tx540 \tab \expndtw-4 \i \f10 \fs64 Takingtoomuchofthismedicationcancause
\plain\par
\pard\pard\sl-767 \li542 \ri19 \expndtw-1 \i \f10 \fs64 severebleeding.\i0 Anticoa
gulantsshouldalsobe
\plain\par
\pard\pard\sl-768 \li542 \ri7213 \expndtw-9 \f10 \fs64 takenonschedule.
\par
\plain\tx540 \tab \expndtw-9 \f10 \fs64 However,apatientwhoforgetstotakea
\plain\par
\pard\pard\sl-765 \li542 \ri241 \expndtw-6 \f10 \fs64 misseddoseuntilthenextdayshouldn
ttake
\plain\par
\pard\pard\sl-768 \li542 \ri662 \expndtw-5 \f10 \fs64 themisseddoseatallandshouldnotd
le
\plain\par
\pard\pard\sl-767 \li542 \ri693 \expndtw-6 \f10 \fs64 thenextdose,asthiscouldleadtobl
ing.
\plain\par
\pard\pard\sl-200\fs20\par \par \pard\sl-421 \li11092 \ri2348 \expndtw-44 \f10 \
fs36 14
\par
{\shp
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
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51400514514005145140051451400514514005145140051451400514514005145140051451400514
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51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
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51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145007f307ff071
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}}}
\plain\pard\sl-1076 \li14 \ri5499 \expndtw-40 \b \f10 \fs88 \cf46 Precautions
\par
\plain\tx598 \tab \expndtw-5 \f10 \fs64 Periodicbloodtestsmustbedoneto
\plain\par
\pard\pard\sl-767 \li604 \ri1139 \expndtw-9 \f10 \fs64 checktheblood'sclottingabilit
y.
\par
\plain\tx598 \tab \expndtw-7 \f10 \fs64 Theresultsofthesetestswillhelpto
\plain\par
\pard\pard\sl-767 \li604 \ri1288 \expndtw-12 \f10 \fs64 determinetheproperamountof
\plain\par
\pard\pard\sl-766 \li604 \ri1059 \expndtw-7 \f10 \fs64 medicationtobetakeneachday.
\par
\plain\pard\sl-200\fs20\par \par \par \par \par \pard\sl-429 \li9292 \ri1322 \ex
pndtw-44 \f10 \fs36 15
\par
{\shp

ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
05145140051451400514514005145140051451400514514005145140051451400514514005145140
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05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
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51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
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51400514514005145140051451400514514005145140051451400514514005145140051451400514
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51450014514500145145001451450014514500145145001451450014514500145145001451450014
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51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145007f307ff071
ff001a00729dc338c738a5a4000e94b4005145140051451400514514005145140051451400514514
}}}
\fs50 \bullet }
\plain\tx538 \tab \expndtw-8 \f10 \fs56 Timeisrequiredfornormalclottingabilitytoretur
\plain\par
\pard\pard\sl-672 \li540 \ri4839 \expndtw-10 \f10 \fs56 afteranticoagulanttreatmen
t.
\par
\plain\pard\sl-200\fs20\par \par \par \par \par \par \pard\sl-423 \li1 \ri21 \ex
pndtw-18 {\cf47 \f0\fs50 \bullet }
\plain\tx538 \tab \expndtw-4 \f10 \fs56 Duringthisperiod,patientsmustobservethesame
\plain\par
\pard\pard\sl-671 \li540 \ri578 \expndtw-5 \f10 \fs56 precautionstheyobservedwhileta
kingthedrug.
\par
\plain\pard\sl-200\fs20\par \par \par \par \par \par \pard\sl-422 \li1 \ri18 \ex
pndtw-18 {\cf47 \f0\fs50 \bullet }
\plain\tx538 \tab \expndtw-9 \f10 \fs56 Thelengthoftimeneededforthebloodtoreturnto
\plain\par
\pard\pard\sl-672 \li540 \ri299 \expndtw-6 \f10 \fs56 normaldependsonthetypeofanticoag

ulantdrug
\plain\par
\pard\pard\sl-671 \li540 \ri8005 \expndtw-15 \f10 \fs56 thatwastaken.
\plain\par
\pard\pard\sl-200\fs20\par \pard\sl-461 \li11092 \ri1682 \expndtw-44 \f10 \fs36
16
\par
{\shp
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
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010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
05145140051451400514514005145140051451400514514005145140051451400514514005145140
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51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145007f307ff071
ff001a00729dc338c738a5a4000e94b4005145140051451400514514005145140051451400514514
}}}
\fs50 \bullet }
\plain\tx538 \tab \expndtw-3 \f10 \fs56 Peoplewhoaretakinganticoagulantdrugs
\plain\par
\pard\pard\sl-671 \li544 \ri2709 \expndtw-4 \f10 \fs56 shouldtellallphysicians,denti
sts,
\plain\par
\pard\pard\sl-672 \li544 \ri162 \expndtw-1 \f10 \fs56 pharmacists,andothermedicalpro
fessionals
\plain\par
\pard\pard\sl-670 \li544 \ri21 \expndtw-4 \f10 \fs56 whoprovidemedicaltreatmentsorser
vicesto
\plain\par
\pard\pard\sl-671 \li544 \ri387 \expndtw-7 \f10 \fs56 themthattheyaretakingsuchamedica
ion.
\plain\par
\pard\pard\sl-200\fs20\par \par \pard\sl-412 \li4 \ri637 \expndtw-18 {\cf47 \f0\
fs50 \bullet }
\plain\tx538 \tab \expndtw-4 \f10 \fs56 Theyshouldalsocarryidentificationstating
\plain\par
\pard\pard\sl-672 \li544 \ri1139 \expndtw-7 \f10 \fs56 thattheyareusingananticoagulan
tdrug.
\par
l-423 \li9232 \ri2240 \expndtw-44 \f10 \fs36 17
\par
{\shp
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010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
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2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
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51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
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51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145007f307ff071
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}}}
0\fs57 \bullet }
\plain\tx538 \tab \expndtw-8 \f10 \fs64 Otherprescriptiondrugsoroverthe
\plain\par
\pard\pard\sl-767 \li544 \ri576 \expndtw-2 \f10 \fs64 countermedicine{\f63 \u8212
\'3f}especiallyaspirin{\f63 \u8212\'3f}
\plain\par
\pard\pard\sl-766 \li544 \ri2369 \expndtw-12 \f10 \fs64 shouldnotbetakenwithoutthe
\plain\par
\pard\pard\sl-767 \li544 \ri994 \expndtw-5 \f10 \fs64 prescribingphysicianbeinginfo
rmed.
\par
\plain\tx538 \tab \expndtw-4 \f10 \fs64 Becauseoftheriskofheavybleeding,
\plain\par
\pard\pard\sl-766 \li544 \ri4 \expndtw-6 \f10 \fs64 anyonewhotakesananticoagulantdrug
\plain\par
\pard\pard\sl-767 \li544 \ri2240 \expndtw-9 \f10 \fs64 musttakecaretoavoidinjuries.
\plain\par
\pard\pard\sl-200\fs20\par \par \pard\sl-421 \li9232 \ri2312 \expndtw-44 \f10 \f
s36 18
\par
{\shp
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010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
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0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
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05145140051451400514514005145140051451400514514005145140051451400514514005145140
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51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
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}}}
0\fs57 \bullet }
\plain\tx540 \tab \expndtw-5 \f10 \fs64 Sportsandotherpotentiallyhazardous
\plain\par
\pard\pard\sl-767 \li542 \ri4217 \expndtw-6 \f10 \fs64 activitiesshouldbeavoided.
\par
\plain\tx540 \tab \expndtw-8 \f10 \fs64 Anyfalls,blowstothebodyorhead,orother
\plain\par
\pard\pard\sl-768 \li542 \ri30 \expndtw-5 \f10 \fs64 injuriesshouldbereportedtoaphysic
ian,as
\plain\par
\pard\pard\sl-765 \li542 \ri1310 \expndtw-8 \f10 \fs64 internalbleedingmayoccurwitho
utany
\plain\par
\pard\pard\sl-768 \li542 \ri6485 \expndtw-9 \f10 \fs64 obvioussymptoms.
\par
18 \expndtw-44 \f10 \fs36 19
\par
{\shp
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fs57 \bullet }
\plain\tx538 \tab \expndtw-2 \f10 \fs64 Specialcareshouldbetakeninshavingandin
\plain\par
\pard\pard\sl-767 \li540 \ri3889 \expndtw-9 \f10 \fs64 brushingandflossingtheteeth.
\par
\plain\tx538 \tab \expndtw-5 \f10 \fs64 Softtoothbrushesshouldbeusedandthe
\plain\par
\pard\pard\sl-768 \li540 \ri4141 \expndtw-6 \f10 \fs64 flossingshouldbeverygentle.
\par
\plain\tx538 \tab \expndtw-2 \f10 \fs64 Electricrazorsshouldbeusedinsteadofa
\plain\par
\pard\pard\sl-767 \li540 \ri10474 \expndtw-30 \f10 \fs64 blade.
\plain\par
\pard\pard\sl-501 \li11092 \ri2183 \expndtw-43 \f10 \fs36 20
\par
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0\fs57 \bullet }
\plain\tx538 \tab \expndtw-5 \f10 \fs64 Alcoholcanchangetheway
\plain\par
\pard\pard\sl-690 \li544 \ri1002 \expndtw-9 \f10 \fs64 anticoagulantdrugsaffectthebo
dy.
\par
\plain\tx538 \tab \expndtw-4 \f10 \fs64 Anyonewhotakesthismedicineshould
\plain\par
\pard\pard\sl-690 \li544 \ri12 \expndtw-11 \f10 \fs64 nothavemorethanonetotwodrinksat
\plain\par
\pard\pard\sl-691 \li544 \ri621 \expndtw-8 \f10 \fs64 anytimeandshouldnotdrinkalcohol
\plain\par
\pard\pard\sl-690 \li544 \ri7617 \expndtw-19 \f10 \fs64 everyday.
\par
\plain\pard\sl-200\fs20\par \par \par \par \pard\sl-477 \li9232 \ri2093 \expndtw
-43 \f10 \fs36 21
\par
{\shp
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\plain\pard\sl-1076 \li14 \ri3668 \expndtw-28 \b \f10 \fs88 \cf46 Specialconditio
ns
\par
\plain\tx598 \tab \expndtw-2 \f10 \fs64 Peoplewithspecificmedicalconditions
\plain\par
\pard\pard\sl-690 \li604 \ri2202 \expndtw-11 \f10 \fs64 orwhoaretakingcertainother
\plain\par
\pard\pard\sl-692 \li604 \ri664 \expndtw-5 \f10 \fs64 medicinescanhaveproblemsifthey
\plain\par
\pard\pard\sl-690 \li604 \ri3543 \expndtw-10 \f10 \fs64 takeanticoagulantdrugs.
\par
\expndtw-20 {\cf47 \f0\fs57 \bullet }
\plain\tx598 \tab \expndtw-8 \f10 \fs64 Beforetakingthesedrugs,the
\plain\par
\pard\pard\sl-691 \li604 \ri1941 \expndtw-3 \f10 \fs64 prescribingphysicianshouldbe
\plain\par
\pard\pard\sl-690 \li604 \ri92 \expndtw-7 \f10 \fs64 informedaboutanyofthesecondition
s
\par
pndtw-43 \f10 \fs36 22
\par
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\cf46 ALLERGIES:
\par
\plain\pard\sl-200\fs20\par \par \par \par \par \pard\sl-422 \li64 \ri541 \expnd

tw-18 {\cf47 \f0\fs50 \bullet }
\plain\tx598 \tab \expndtw-3 \f10 \fs56 Anyonewhohashadunusualreactionsto
\plain\par
\pard\pard\sl-671 \li604 \ri510 \expndtw-5 \f10 \fs56 anticoagulantsinthepastshouldle
thisor
\plain\par
\pard\pard\sl-672 \li604 \ri312 \expndtw-5 \f10 \fs56 herphysicianknowbeforetakingthed
rugs
\plain\par
\pard\pard\sl-670 \li604 \ri8527 \expndtw-25 \f10 \fs56 again.
\par
\plain\pard\sl-200\fs20\par \par \par \par \par \par \pard\sl-423 \li64 \ri91 \e
xpndtw-18 {\cf47 \f0\fs50 \bullet }
\plain\tx598 \tab \expndtw-3 \f10 \fs56 Thephysicianshouldalsobetoldaboutany
\plain\par
\pard\pard\sl-672 \li604 \ri29 \expndtw-11 \b \f10 \fs56 allergies\b0 tobeef,pork,oro
therfoods;dyes;
\plain\par
\pard\pard\sl-671 \li604 \ri2190 \expndtw-3 \f10 \fs56 preservatives;orothersubstan
ces.
\par
9 \expndtw-43 \f10 \fs36 23
\par
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\cf46 PREGNANCY
\par
\plain\pard\sl-200\fs20\par \par \par \par \par \pard\sl-502 \li64 \ri1901 \expn
dtw-20 {\cf47 \f0\fs57 \bullet }
\plain\tx598 \tab \expndtw-3 \f10 \fs64 Anticoagulantsmaycausemany
\plain\par
\pard\pard\sl-767 \li604 \ri2034 \expndtw-7 \f10 \fs64 seriousproblemsiftakenduring
\plain\par
\pard\pard\sl-766 \li604 \ri7115 \expndtw-34 \b \f10 \fs64 pregnancy\b0 .
\par
\plain\pard\sl-200\fs20\par \par \par \par \par \par \par \pard\sl-456 \li64 \ri

\plain\tx598 \tab \expndtw-12 \b \f10 \fs64 Birthdefects\b0 ,severebleedinginthe
\plain\par
\pard\pard\sl-767 \li604 \ri20 \expndtw-10 \f10 \fs64 fetus,andotherproblemsthataffec
tthe
\plain\par
\pard\pard\sl-766 \li604 \ri500 \expndtw-7 \f10 \fs64 physicalormentaldevelopmentofth
e
\plain\par
\pard\pard\sl-767 \li604 \ri2479 \expndtw-7 \f10 \fs64 fetusornewbornarepossible.
\plain\par
\pard\pard\sl-200\fs20\par \par \pard\sl-421 \li9292 \ri2165 \expndtw-43 \f10 \f
s36 24
\par
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}}}
0\fs57 \bullet }
\plain\tx540 \tab \expndtw-2 \f10 \fs64 Themothermayalsoexperiencesevere
\plain\par
\pard\pard\sl-767 \li542 \ri1298 \expndtw-5 \f10 \fs64 bleedingifshetakesanticoagula
ntsduring
\plain\par
\pard\pard\sl-768 \li542 \ri18 \expndtw-7 \f10 \fs64 pregnancy,duringdelivery,orevens
hortlyafter
\plain\par
\pard\pard\sl-767 \li542 \ri10025 \expndtw-22 \f10 \fs64 delivery.
\plain\par
\pard\pard\sl-200\fs20\par \par \pard\sl-528 \li1 \ri3151 \expndtw-20 {\cf47 \f0
\fs57 \bullet }
\plain\tx540 \tab \expndtw-9 \i \f10 \fs64 Womenshouldnottakestarttaking
\plain\par
\pard\pard\sl-765 \li542 \ri883 \expndtw-4 \i \f10 \fs64 anticoagulantsduringpregn
ancyandshould
\plain\par
\pard\pard\sl-768 \li542 \ri2958 \expndtw-10 \i \f10 \fs64 notbecomepregnantwhiletak
ingit.
\par
71 \expndtw-43 \f10 \fs36 25
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}}}
\cf46 BREASTFEEDING:
\par
\plain\tx598 \tab \expndtw-2 \f10 \fs56 Someanticoagulantdrugsmaypassinto
\plain\par
\pard\pard\sl-672 \li604 \ri7538 \expndtw-16 \f10 \fs56 breastmilk.
\par
\plain\tx598 \tab \expndtw-2 \f10 \fs56 Bloodtestscanbedoneonnursingbabiesto
\plain\par
\pard\pard\sl-671 \li604 \ri2044 \expndtw-5 \f10 \fs56 seewhetherthedrugiscausingany
\plain\par
\pard\pard\sl-670 \li604 \ri7903 \expndtw-17 \f10 \fs56 problems.
\par
\plain\tx598 \tab \expndtw-7 \f10 \fs56 Ifitis,othermedicationmaybeprescribedto
\plain\par
\pard\pard\sl-671 \li604 \ri755 \expndtw-7 \f10 \fs56 counteracttheeffectsoftheantico
agulant
\plain\par
\pard\pard\sl-671 \li604 \ri2075 \expndtw-40 \f10 \fs56 drug.
\plain\tx9269 \tab \expndtw-43 \f10 \fs36 26
\par
{\shp
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}}}
\plain\pard\sl-1076 \li14 \ri3894 \expndtw-26 \b \f10 \fs88 \cf46 OTHERMEDICAL
\plain\par
\pard\pard\sl-1053 \li14 \ri5741 \expndtw-47 \b \f10 \fs88 \cf46 CONDITIONS
\par
\plain\tx598 \tab \expndtw-6 \f10 \fs64 Beforeusinganticoagulantdrugs,
\plain\par
\pard\pard\sl-690 \li604 \ri849 \expndtw-6 \f10 \fs64 peopleshouldinformtheirphysici
an
\plain\par
\pard\pard\sl-692 \li604 \ri15 \expndtw-6 \f10 \fs64 about\i any\i0 medicalproblemst
heyhave.
\par
\plain\pard\sl-200\fs20\par \par \par \par \par \par \pard\sl-500 \li64 \ri172 \
expndtw-20 {\cf47 \f0\fs57 \bullet }
\plain\tx598 \tab \expndtw-5 \f10 \fs64 Theyshouldalsoletthephysicianwho
\plain\par
\pard\pard\sl-690 \li604 \ri718 \expndtw-8 \f10 \fs64 prescribedthemedicineknowifthey
\plain\par
\pard\pard\sl-691 \li604 \ri210 \expndtw-8 \f10 \fs64 arebeingtreatedbyanyothermedical
\plain\par
\pard\pard\sl-690 \li604 \ri4938 \expndtw-11 \f10 \fs64 physicianordentist.
\par
pndtw-43 \f10 \fs36 27
\par
{\shp
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}}}
fs57 \bullet }
\plain\tx538 \tab \expndtw-11 \f10 \fs64 Inaddition,peoplewhowillbetaking
\plain\par
\pard\pard\sl-767 \li544 \ri476 \expndtw-8 \f10 \fs64 anticoagulantdrugsshouldletthe
ir
\plain\par
\pard\pard\sl-766 \li544 \ri213 \expndtw-7 \f10 \fs64 physicianknowiftheyhaverecently
\plain\par
\pard\pard\sl-767 \li544 \ri3351 \expndtw-15 \f10 \fs64 hadanyofthefollowing:
\par
ar \par \par \par \par \par \par \par \pard\sl-411 \li9232 \ri1373 \expndtw-43 \
f10 \fs36 28
\par
{\shp
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0\fs43 \bullet }
\plain\tx538 \tab \expndtw-9 \b \f10 \fs48 fever\b0 lastingmorethanonetotwodays
\plain\par
\pard\pard\sl-200\fs20\par \pard\sl-438 \li4 \ri4513 \expndtw-15 {\cf47 \f0\fs43
\bullet }
\plain\tx538 \tab \expndtw-10 \f10 \fs48 severeorcontinuing\b diarrhea\b0
\plain\par
\bullet }
\plain\tx538 \tab \expndtw-18 \f10 \fs48 {\ul c}{\ul h}{\ul i}{\ul l}{\ul d}{\ul
b}{\ul i}{\ul r}{\ul t}{\ul h}{\ul }
\plain\par
\bullet }
\plain\tx538 \tab \expndtw-4 \f10 \fs48 heavyorunusualmenstrualbleeding
\plain\par
\pard\pard\sl-200\fs20\par \pard\sl-436 \li4 \ri22 \expndtw-15 {\cf47 \f0\fs43 \
bullet }
\plain\tx538 \tab \expndtw-7 \f10 \fs48 insertionofanintrauterinecontraceptivedevice(\
b IUD\b0 )
\plain\par
\bullet }
\plain\tx538 \tab \expndtw-6 \f10 \fs48 falls,injuries,orblowstothebodyorhead
\plain\par
\bullet }
\plain\tx538 \tab \expndtw-5 \f10 \fs48 anytypeofsurgery,includingdentalsurgery
\plain\par
\bullet }
\plain\tx538 \tab \expndtw-4 \f10 \fs48 spinalanesthesia
\plain\par
\bullet }
\plain\tx538 \tab \expndtw-12 \f10 \fs48 radiationtreatment
\par
5 \expndtw-43 \f10 \fs36 29
\par
{\shp
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\plain\pard\sl-783 \li14 \ri1547 \expndtw-9 \b \f10 \fs64 \cf46 USEOFCERTAINFOODSAND
\plain\par
\pard\pard\sl-768 \li14 \ri6831 \expndtw-42 \b \f10 \fs64 \cf46 MEDICINES\b0
\par
\plain\tx598 \tab \expndtw-7 \f10 \fs64 Manyfoodsanddrugsmayaffectthe
\plain\par
\pard\pard\sl-767 \li604 \ri292 \expndtw-9 \f10 \fs64 waytheanticoagulantdrugsworkor
\plain\par
\pard\pard\sl-766 \li604 \ri353 \expndtw-5 \f10 \fs64 mayincreasetheriskofsideeffects.
\par
ri1484 \expndtw-44 \f10 \fs36 30
\par
{\shp
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}}}
\plain\pard\sl-1076 \li1814 \ri6651 \expndtw-40 \b \f10 \fs88 \cf46 Sideeffects
\par
\plain\tx540 \tab \expndtw-5 \f10 \fs64 Themostcommonminorsideeffectsare
\plain\par
\pard\pard\sl-767 \li542 \ri8147 \expndtw-15 \f10 \fs64 bloatingorgas.
\plain\par
fs57 \bullet }
\plain\tx540 \tab \expndtw-2 \f10 \fs64 Theseproblemsusuallygoawayasthebody
\plain\par
\pard\pard\sl-767 \li542 \ri381 \expndtw-8 \f10 \fs64 adjuststothedruganddonotrequire
ical
\plain\par
\pard\pard\sl-768 \li542 \ri9650 \expndtw-29 \f10 \fs64 treatment.
\plain\par
\pard\pard\sl-200\fs20\par \par \pard\sl-525 \li1 \ri18 \expndtw-20 {\cf47 \f0\f
s57 \bullet }
\plain\tx540 \tab \expndtw0 \f10 \fs64 Moreserioussideeffectsmayoccur,especially
\plain\par
\pard\pard\sl-768 \li542 \ri3216 \expndtw-4 \f10 \fs64 ifexcessiveanticoagulantistak
en.
\plain\par
\fs57 \bullet }
\plain\tx540 \tab \expndtw-13 \f10 \fs64 bleedinggums
\plain\par
31
\par
{\shp
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}}\margt-40\margb60\margr620\margl140
\plain\pard\sl-200\fs20\par \pard\sl-553 \li1 \ri887 \expndtw-20 {\cf47 \f0\fs57
\bullet }
\plain\tx538 \tab \expndtw-10 \f10 \fs64 soresorwhitespotsinthemouthorthroat
\par
\plain\tx538 \tab \expndtw-6 \f10 \fs64 unusual\b bruises\b0 orpurplishareasontheskin
\par
\plain\tx538 \tab \expndtw-2 \f10 \fs64 unexplainednosebleeds
\par
\plain\tx538 \tab \expndtw-5 \f10 \fs64 unusuallyheavybleedingoroozingfrom
\plain\par
\pard\pard\sl-767 \li540 \ri9451 \expndtw-42 \b \f10 \fs64 wounds\b0
\par
\plain\tx538 \tab \expndtw-4 \f10 \fs64 unexpectedorunusuallymenstrualbleeding
\plain\par
32
\par
\pard\sl-80\fs8\sect\sectd\sbkpage\margtsxn-120\pard
{\shp
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}}}
0\fs57 \bullet }
\plain\tx538 \tab \expndtw-16 \f10 \fs64 bloodintheurine
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-13 \f10 \fs64 cloudyordarkurine
\plain\par
s57 \bullet }
\plain\tx538 \tab \expndtw-10 \f10 \fs64 painfulordifficulturinationorsudden
\plain\par
\pard\pard\sl-767 \li544 \ri2302 \expndtw-8 \f10 \fs64 decreaseinamountofurine
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-9 \f10 \fs64 black,tarry,orbloodystools
\par
ar \par \pard\sl-363 \li9232 \ri1412 \expndtw-44 \f10 \fs36 33
\par
{\shp
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}}}
0\fs57 \bullet }
\plain\tx538 \tab \expndtw-12 \f10 \fs64 coughingupblood
\plain\par
s57 \bullet }
\plain\tx538 \tab \expndtw-9 \f10 \fs64 vomitingbloodorsomethingthatlooks
\plain\par
\pard\pard\sl-768 \li544 \ri5015 \expndtw-10 \f10 \fs64 likecoffeegrounds
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-16 \f10 \fs64 constipation
\par
ar \par \par \par \par \par \pard\sl-491 \li9232 \ri1826 \expndtw-44 \f10 \fs36
34
\par
{\shp
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0\fs57 \bullet }
\plain\tx538 \tab \expndtw-11 \b \f10 \fs64 pain\b0 orswellinginthestomachor
\plain\par
\pard\pard\sl-767 \li544 \ri7790 \expndtw-22 \f10 \fs64 abdomen
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-18 \f10 \fs64 backpain
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-12 \f10 \fs64 stiff,swollen,orpainfuljoints
\plain\par
s57 \bullet }
\plain\tx538 \tab \expndtw-8 \f10 \fs64 painful,bluishorpurplishfingersortoes
\par
\par
{\shp
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fs57 \bullet }
\plain\tx538 \tab \expndtw-8 \f10 \fs64 puffyorswolleneyelids,face,feet,or
\plain\par
\pard\pard\sl-767 \li544 \ri6912 \expndtw-18 \f10 \fs64 lowerlegs
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-8 \f10 \fs64 changesinthecoloroftheface
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-15 \f10 \fs64 skinrash,\b itching\b0 ,or\b hives\b0
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-9 \f10 \fs64 yelloweyesorskin
\par
\par
{\shp
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}}}
0\fs50 \bullet }
\plain\tx538 \tab \expndtw-10 \f10 \fs56 severeorcontinuing\b headache\b0
\plain\par
s50 \bullet }
\plain\tx538 \tab \expndtw-9 \f10 \fs56 sorethroatandfever,withorwithoutchills
\plain\par
\fs50 \bullet }
\plain\tx538 \tab \expndtw-13 \f10 \fs56 breathingproblemsor\b wheezing\b0
\plain\par
\fs50 \bullet }
\plain\tx538 \tab \expndtw-9 \f10 \fs56 tightnessinthechest
\plain\par
\fs50 \bullet }
\plain\tx538 \tab \expndtw-5 \f10 \fs56 dizziness
\plain\par
\fs50 \bullet }
\plain\tx538 \tab \expndtw-2 \f10 \fs56 unusualtirednessorweakness
\plain\par
\fs50 \bullet }
\plain\tx538 \tab \expndtw-19 \f10 \fs56 weightgain
\par
2 \expndtw-44 \f10 \fs36 37

\par
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0\fs57 \bullet }
\plain\tx538 \tab \expndtw-12 \f10 \fs64 nauseaorvomiting
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-23 \f10 \fs64 diarrhea
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-7 \f10 \fs64 stomachpainorcramps
\par
ar \par \par \par \par \par \par \par \par \par \pard\sl-459 \li9232 \ri62 \expn
dtw-44 \f10 \fs36 38
\par
{\shp
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\plain\pard\sl-832 \li14 \ri6407 \expndtw-38 \b \f10 \fs64 \cf46 DDInteractions
\par
\plain\tx598 \tab \expndtw-8 \f10 \fs64 Anticoagulantsmayinteractwithmany
\plain\par
\pard\pard\sl-767 \li604 \ri26 \expndtw-5 \f10 \fs64 othermedications.Whenthishappen
s,
\plain\par
\pard\pard\sl-766 \li604 \ri412 \expndtw-11 \f10 \fs64 theeffectsofoneorbothofthedrug
\plain\par
\pard\pard\sl-767 \li604 \ri438 \expndtw-6 \f10 \fs64 maychangeortheriskofsideeffects
\plain\par
\pard\pard\sl-768 \li604 \ri5270 \expndtw-8 \f10 \fs64 maybeincreased.
\par
ar \par \par \par \pard\sl-443 \li9292 \ri1952 \expndtw-44 \f10 \fs36 39
\par
{\shp
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\plain\pard\sl-200\fs20\par \par \pard\sl-530 \li1 \ri1 \expndtw-20 {\cf47 \f0\f
s57 \bullet }
\plain\tx540 \tab \expndtw-4 \i \f10 \fs64 Anyonewhotakesanticoagulantsshouldinform
\plain\par
\pard\pard\sl-767 \li542 \ri2786 \expndtw-7 \i \f10 \fs64 theprescribingphysicianab
outother
\plain\par
\pard\pard\sl-768 \li542 \ri1955 \expndtw-8 \i \f10 \fs64 prescriptionornonprescri
ption(overthe
\plain\par
\pard\pard\sl-767 \li542 \ri672 \expndtw-4 \i \f10 \fs64 countermedicines)heorsheistak
ing{\f63 \u8212\'3f}even
\plain\par
\pard\pard\sl-768 \li542 \ri1920 \expndtw-4 \i \f10 \fs64 aspirin,laxatives,vitami
ns,andantacids.
\par
ar \par \par \par \pard\sl-443 \li11092 \ri2492 \expndtw-44 \f10 \fs36 40
\par
{\shp
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}}}

fs57 \bullet }
\plain\tx538 \tab \expndtw-6 \f10 \fs64 Dietalsoaffectsthewayanticoagulant
\plain\par
\pard\pard\sl-767 \li544 \ri3895 \expndtw-14 \f10 \fs64 drugsworkinthebody.
\par
\plain\tx538 \tab \expndtw-5 \f10 \fs64 Anormal,balanceddietshouldbe
\plain\par
\pard\pard\sl-768 \li544 \ri536 \expndtw-7 \f10 \fs64 followedeverydaywhiletakingsuch
\plain\par
\pard\pard\sl-767 \li544 \ri6904 \expndtw-18 \f10 \fs64 medication.
\par
\li9232 \ri1826 \expndtw-44 \f10 \fs36 41
\par
{\shp
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010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
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}}}
\fs57 \bullet }
\plain\tx538 \tab \expndtw-7 \f10 \fs64 Dietisaveryimportantconsideration
\plain\par
\pard\pard\sl-767 \li544 \ri28 \expndtw-8 \f10 \fs64 becausetheamountofvitaminKinthe
\plain\par
\pard\pard\sl-766 \li544 \ri472 \expndtw-7 \f10 \fs64 bodyaffectshowanticoagulantdru
gs
\plain\par
\pard\pard\sl-767 \li544 \ri8593 \expndtw-41 \f10 \fs64 work.
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-8 \f10 \fs64 Dicoumarolandwarfarinactby
\plain\par
\pard\pard\sl-767 \li544 \ri1625 \expndtw-9 \f10 \fs64 reducingtheeffectsofvitaminK.
\par
\par
{\shp
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0\fs57 \bullet }
\plain\tx538 \tab \expndtw-7 \f10 \fs64 VitaminKisfoundinmeats,dairy
\plain\par
\pard\pard\sl-767 \li544 \ri93 \expndtw-5 \f10 \fs64 products,leafy,greenvegetables
,and
\plain\par
\pard\pard\sl-766 \li544 \ri30 \expndtw-13 \f10 \fs64 somemultiple\b vitamins\b0 an
dnutritional
\plain\par
\pard\pard\sl-767 \li544 \ri6582 \expndtw-13 \f10 \fs64 supplements
\par
ar \par \par \par \par \par \par \par \pard\sl-411 \li9232 \ri1826 \expndtw-44 \
f10 \fs36 43
\par
{\shp
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010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
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\fs57 \bullet }
\plain\tx538 \tab \expndtw-9 \f10 \fs64 Forthedrugstoworkproperly,itisbest
\plain\par
\pard\pard\sl-767 \li544 \ri15 \expndtw-9 \f10 \fs64 tohavethesameamountofvitaminKin
\plain\par
\pard\pard\sl-766 \li544 \ri4971 \expndtw-16 \f10 \fs64 thebodyallthetime.
\par
ri2258 \expndtw-44 \f10 \fs36 44
\par
{\shp
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0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
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31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
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6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
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05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
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b451457d59e785145140051451400514514005145140051451400514514005145140051451400514
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51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
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51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145007f307ff071
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}}}
\fs57 \bullet }
\plain\tx538 \tab \expndtw-9 \f10 \fs64 Ifthepatienttakesvitaminsupplements,he
\plain\par
\pard\pard\sl-767 \li540 \ri689 \expndtw-5 \f10 \fs64 shouldcheckthelabeltoseeifitcon
ns
\plain\par
\pard\pard\sl-768 \li540 \ri8780 \expndtw-22 \f10 \fs64 vitaminK.
\par
\plain\tx538 \tab \expndtw0 \f10 \fs64 BecausevitaminKisalsoproducedby
\plain\par
\pard\pard\sl-765 \li540 \ri19 \expndtw-3 \f10 \fs64 intestinalbacteria,aseverecaseofd
iarrhea
\plain\par
\pard\pard\sl-768 \li540 \ri1294 \expndtw-12 \f10 \fs64 ortheuseof\b laxatives\b0 maya
lsoaltera
\plain\par
\pard\pard\sl-767 \li540 \ri4988 \expndtw-5 \f10 \fs64 person'svitaminKlevels
\plain\par
fs36 45
\par
{\shp
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
b451457d59e785145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145007f307ff071
ff001a00729dc338c738a5a4000e94b4005145140051451400514514005145140051451400514514
}}}
\plain\pard\sl-200\fs20\par \pard\sl-930 \li1814 \ri5897 \expndtw-21 \b \f10 \fs
88 \cf46 KEYTERMS
\par
\plain\pard\sl-200\fs20\par \par \par \par \par \pard\sl-502 \li1 \ri659 \expndt
w-20 {\cf47 \f0\fs57 \bullet }
\plain\tx538 \tab \expndtw-13 \b \f10 \fs64 Anticoagulant\b0 {\f63 \u8212\'3f}Dr
ugusedtopreventclot
\plain\par
\pard\pard\sl-767 \li540 \ri27 \expndtw-11 \f10 \fs64 formationortopreventaclotthathas
rmed
\plain\par
\pard\pard\sl-766 \li540 \ri7668 \expndtw-18 \f10 \fs64 fromenlarging.
\par
\plain\tx538 \tab \expndtw-8 \f10 \fs64 Anticoagulantdrugsinhibitclotformationby
\plain\par
\pard\pard\sl-767 \li540 \ri1559 \expndtw-9 \f10 \fs64 blockingtheactionofclottingfac
torsor
\plain\par
\pard\pard\sl-766 \li540 \ri508 \expndtw-7 \f10 \fs64 platelets.Anticoagulantdrugsf
allintothree
\plain\par
\pard\pard\sl-767 \li540 \ri183 \expndtw-8 \f10 \fs64 groups:inhibitorsofclottingfac
torsynthesis,
\plain\par
\pard\pard\sl-821 \li540 \ri510 \expndtw-9 \f10 \fs64 inhibitorsofthrombinandantipla
teletdrugs.
\plain\par
\pard\pard\sl-360 \li11092 \ri1808 \expndtw-44 \f10 \fs36 46
\par
{\shp
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
b451457d59e785145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145007f307ff071
ff001a00729dc338c738a5a4000e94b4005145140051451400514514005145140051451400514514
}}}
\fs57 \bullet }
\plain\tx538 \tab \expndtw-19 \b \f10 \fs64 Antiplateletdrug\b0 {\f63 \u8212\'3f}
Drugthatinhibits
\plain\par
\pard\pard\sl-767 \li544 \ri733 \expndtw-11 \f10 \fs64 plateletsfromaggregatingtofor
ma
\plain\par
\pard\pard\sl-766 \li544 \ri26 \expndtw-9 \f10 \fs64 plug.Theyareusedtopreventclotting
\plain\par
\pard\pard\sl-767 \li544 \ri2169 \expndtw-10 \f10 \fs64 andalterthenaturalcourseof
\plain\par
\pard\pard\sl-768 \li544 \ri5936 \expndtw-5 \f10 \fs64 atherosclerosis.
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-10 \b \f10 \fs64 Atherosclerosis\b0 {\f63 \u8212\'3f}
Condition
\plain\par
\pard\pard\sl-767 \li544 \ri1395 \expndtw-7 \f10 \fs64 characterizedbydepositsoffatt
y
\plain\par
\pard\pard\sl-766 \li544 \ri4440 \expndtw-11 \f10 \fs64 plaqueinthearteries.
\plain\par
\pard\pard\sl-200\fs20\par \par \par \pard\sl-381 \li9232 \ri1790 \expndtw-44 \f
10 \fs36 47
\par
{\shp
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
b451457d59e785145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145007f307ff071
ff001a00729dc338c738a5a4000e94b4005145140051451400514514005145140051451400514514
}}}

0\fs57 \bullet }
\plain\tx538 \tab \expndtw-6 \b \f10 \fs64 Clot\b0 {\f63 \u8212\'3f}Asoft,semisolidm
assthat
\plain\par
\pard\pard\sl-767 \li544 \ri4216 \expndtw-9 \f10 \fs64 formswhenbloodgels.
\plain\par
s57 \bullet }
\plain\tx538 \tab \expndtw-9 \b \f10 \fs64 Platelet\b0 {\f63 \u8212\'3f}Asmall,dis
kshapedbodyin
\plain\par
\pard\pard\sl-767 \li544 \ri319 \expndtw-11 \f10 \fs64 thebloodthathasanimportantrolei
\plain\par
\pard\pard\sl-768 \li544 \ri192 \expndtw-13 \f10 \fs64 bloodclotting:theyformtheiniti
alplug
\plain\par
\pard\pard\sl-767 \li544 \ri1019 \expndtw-8 \f10 \fs64 attherupturesiteofabloodvessel.
\par
\par
{\shp
ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101
01010101010101010101010101010101010101010101010101010101010101010101010101010101
010101010101010101ffdb0043010101010101010101010101010101010101010101010101010101
0101010101010101010101010101010101010101010101010101010101010101010101010101ffc0
001108046505dc03012200021101031101ffc4001f00000105010101010101000000000000000001
02030405060708090a0bffc400b5100002010303020403050504040000017d010203000411051221
31410613516107227114328191a1082342b1c11552d1f02433627282090a161718191a2526272829
2a3435363738393a434445464748494a535455565758595a636465666768696a737475767778797a
0101010101010101010000000000000102030405060708090a0bffc400b511000201020404030407
05040400010277000102031104052131061241510761711322328108144291a1b1c109233352f015
6272d10a162434e125f11718191a262728292a35363738393a434445464748494a53545556575859
5a636465666768696a737475767778797a82838485868788898a92939495969798999aa2a3a4a5a6
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
05145140051451400514514005145140051451400514514005145140051451400514514005145140
b451457d59e785145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51400514514005145140051451400514514005145140051451400514514005145140051451400514
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145001451450014
51450014514500145145001451450014514500145145001451450014514500145145007f307ff071
ff001a00729dc338c738a5a4000e94b4005145140051451400514514005145140051451400514514
}}}
fs57 \bullet }
\plain\tx538 \tab \expndtw-10 \b \f10 \fs64 Thrombin\b0 {\f63 \u8212\'3f}Thrombi
nisaproteinproducedby
\plain\par
\pard\pard\sl-767 \li540 \ri9604 \expndtw-26 \f10 \fs64 thebody.
\plain\par
\fs57 \bullet }
\plain\tx538 \tab \expndtw-9 \f10 \fs64 Itisaspecificclottingfactorthatplaysan
\plain\par
\pard\pard\sl-767 \li540 \ri1167 \expndtw-8 \f10 \fs64 importantroleinthebloodclottin
gprocess.
\plain\par
fs57 \bullet }
\plain\tx538 \tab \expndtw-14 \b \f10 \fs64 Thrombininhibitor\b0 {\f63 \u8212\'3f
}Thrombininhibitorsare
\plain\par
\pard\pard\sl-765 \li540 \ri399 \expndtw-7 \f10 \fs64 onetypeofanticoagulantmedicati
on,usedto
\plain\par
\pard\pard\sl-768 \li540 \ri17 \expndtw-9 \f10 \fs64 helppreventformationofharmfulblo
odclotsin
\plain\par
\pard\pard\sl-767 \li540 \ri811 \expndtw-10 \f10 \fs64 thebodybyblockingtheactivityoft
rombin
\plain\par
fs36 49
\par
}

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