NOTRE DAME OF TACURONG COLLEGE

COLLEGE OF NURSING CITY OF TACURONG

Drug Study
NAME: Generic: chlorambucil Brand name: Leukeran Classification: Antineoplastics, immunosuppresants Mode of Administration: Route: IVTT Dosage: 0.1mg/kg Time: OD DRUG ACTION: Mechanism of Action: Damages DNA before mitosis (cycle-dependent and phase-specific). Death of rapidly replicating cells, particularly malignant ones. SIDE EFFECT: Nausea Vomiting Stomatitis Rash CONTRAINDICATIO N: Contraindicated in: Hypersensitivity; Previous resistance; OB; Lactation: Can cause fetal or Neonatal harm; Avoid becoming pregnant; do not breast feed. Special Precaution: Use cautiously in: Infection; Other chronic debilitating diseases; Geri: More sensitive to effects. Drug Interaction: Allopurinol decreases metabolism of mercaptopurine. Toxicity from methotrexate may be increased by other nephrotoxic drugs or larger doses of aspirin NSG. RESPONSIBILITIES 1. Check for doctors order. R: To be assure that you are giving the right medication and dose to the right patient. 2. Verify the patient and explain the action of the drug. R: To check the right patient and so that the patient will be aware by explaining the action of the drug. 3. Observe for 10 rights in preparing and administering of drug. R: To prevent error. 4. Stay on the patient side and observe for any untoward effects. R: For immediate nursing care. 5. Perform hand washing before giving the medication.

Adverse Effect: Resp: Pulmonary fibrosis. GU: Decreased sperm count, Sterility. Bibliography: Derm: alopecia, Daviss Drug Guide dermatitis for Nurses Hemat: leucopenia, 11TH Edition anemia, thrombocytopenia Metab: hyperuricemia Misc: allergy reactions, Risk of second malignancy.

Indication: Management of chronic lymphocytic leukemia, malignant lymphoma, and Hodgkins disease.

or NSAIDs. Bone marrow depression is additive.

R: To prevent transmission of microorganism. 6. Advise the patient to eat dry crackers. R: To prevent nausea and vomiting. 7. Instruct patient to use soft toothbrush if stomatitis will occur. R: To prevent pain and lesion during brushing of teeth. 8. Offer attractive foods to the patient. R: To prevent anorexia. 9. Encourage the patient to stay in bed and limit activities when dizziness will occur. R: To prevent any accident. 10. Encourage the patient to take foods rich in potassium such as bananas and apple. R: to prevent dehydration when diarrhea will occur.