Name of drug Clindamycin

General Action ANTIBIOTIC; Anti- infectives

Specific Action - inhibits bacterial protein synthesis by binding to 50S subunit of ribosome. - hinders or kills susceptible bacteria.

Adverse Effects CNS: headache CV: Thrombophlebitis EENT: pharyngitis GI: abdominal pain, Anorexia, bloody or tarry stools, constipation, diarrhea, dysphagia, esophagitis, flatulence, nausea, psuedomembranus colitis, unpleasant or bitter taste, vomiting. GU: UTI HEMATOLOGIC: Eosinophilia, thrombocytopenia, transient leukopenia SKIN: maculopapular rash, urticaria OTHER: anaphylaxis, erythema, pain (I.V. use), induration, pain; sterile abcess (I.M. use)

Indication - infections caused by sensitive staphylococci, streptococci, pneumococci, bacteroides, fusibacterium, clostridium perfringens, and other sensitive aerobic and anaerobic organisms. -endocarditis prophylaxis for dental procedures in patients allergic to penicillin -acne vulgaris -bacterial vaginosis - pneumocystis jiroveci (carinii) pneumonia -toxoplasmosis (cerebral or ocular) immunocompromised patients

Contraindication -contraindicated in patients hypersensitive to drug or lincomycin -use cautiously in patients with renal or hepatic disease, asthma, history of GI disease, or significant allergies.

Nursing Responsibilities

-assess patients infection before and regularly throughout therapy -before giving first dose, obtain specimen for culture and sensitivity test, begin therapy pending results. -monitor renal, hepatic, and hematopoetic functions during prolonged therapy. -be alert for adverse reactions and drug interactions -if adverse GI reactions occurs, monitor patients hydration. -teach patient how to store oral solution. -tell patient to take entire amount prescribed even after he feels better. -warn patient that I.M. injection may be painful -instruct patient to report diarrhea and to avoid self-threatening psudomembranus colitis -tell patient receiving drug I.V. to report discomfort at infusion site.