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The accounting of all mass in a chemical/pharmaceutical process is referred to as a mass (or material) balance.
Uses
day to day operation of process for monitoring operating efficiency Making calculations for design and development of a process i.e. quantities required, sizing equipment, number of items of equipment
continued
Total initial mass = total final mass = 300 kg Initial methanol mass = final methanol mass 80 + 70 = final methanol mass = 150 kg Therefore final composition of batch is (150/300) x 100 = 50 % by wt.
Exercise
1000 kg of 8% by wt. sodium hydroxide (NaOH) solution is required. 20% sodium hydroxide solution in water and pure water are available. How much of each is required?
Batch processes
Batch processes operate to a batch cycle and are non-steady state. Materials are added to a vessel in one operation and then process is carried out and batch cycle repeated. Integral balances are carried out on batch processes where balances are carried out on the initial and final states of the system.
Paul Ashall, 2008
Batch cycle
Sequence of operations/steps repeated according to a cycle Batch cycle time Batch size
t, finish cycle
Continuous processes
These processes are continuous in nature and operate in steady state and balances are carried out over a fixed period of time. Materials enter and leave process continuously.
Notes: 1. generation and consumption terms refer only to generation of products and consumption of reactants as a result of chemical reaction. If there is no chemical reaction then these terms are zero. 2. Apply to a system 3. Apply to total mass and component mass
Paul Ashall, 2008
Definitions
System arbritary part or whole of a system Steady state/non-steady state Accumulation/depletion of mass in system Basis for calculation of mass balance (unit of time, batch etc) Component or substance
Paul Ashall, 2008
Exercise
1000 kg of a 10 % by wt. sodium chloride solution is concentrated to 50 % in a batch evaporator. Calculate the product mass and the mass of water evaporated from the evaporator.
Mixing of streams
F2 F1 F4
F3
Example
Calculate E and x
evaporator feed E, composition x%
Flowsheets
Streams Operations/equipment sequence Standard symbols
Flowsheets
Process flow diagram PID
product
waste
Byproducts/coproducts
Exercise
A 1000 kg batch of a pharmaceutical powder containing 5 % by wt water is dried in a double cone drier. After drying 90 % of the water has been removed. Calculate the final batch composition and the weight of water removed.
Molar units
A mole is the molecular weight of a substance expressed in grams To get the molecular weight of a substance you need its molecular formula and you can then add up the atomic weights of all the atoms in the molecule To convert from moles of a substance to grams multiply by the molecular weight To convert from grams to moles divide by the molecular weight. Mole fraction is moles divided by total moles Paul Ashall, 2008 Mole % is mole fraction multiplied by 100
Molar units
Benzene is C6H6. The molecular weight is (6x12) + (6x1) = 78 So 1 mole of benzene is 78 grams 1 kmol is 78 kg
T deg cent
80
70 60 50 40
51.1
48.3 45.5 42.6 40
30
20 10
37
34 31
Paul Ashall, 2008
27.6
At 80 deg cent satd soln contains (51.1/151.1)x100 % KCl i.e. 33.8% by wt So in 1000 kg there is 338 kg KCl & 662 kg water. Crystallising 100 kg out of soln leaves a satd soln containing 238 kg KCl and 662kg water i.e. 238/6.62 g KCl/100g water which is 36 g KCl/100g. So temperature required is approx 27 deg cent from table.
Paul Ashall, 2008
wash water/solvent
feed suspension solid
waste water
filtrate
Paul Ashall, 2008
Filtration
5000 kg DM water
F1
Impurity 55 kg Water 2600 kg API 450 kg Water 7300 kg Impurity 50 kg API 2kg
Paul Ashall, 2008
feed
product
A+B
A+B
S+B
feed E1
raffinate
solvent
extract
F = 195 kg; xf = 0.11 kg API/kgwater S = 596 kg chloroform y = 1.72x, where y is kgAPI/kg chloroform in extract and x is kg API/kg water in raffinate. Total balance 195 + 596 = E + R API balance 19.5 = 175.5x1 + 596y1 19.5 = 175.5x1 + 596.1.72x1 x1 = 0.0162 and y1 = 0.029 R is 175.5 kg water + 2.84 kg API and E is 596 kg chloroform + 17.28 kg API
Note: chloroform and water are essentially immiscible
Paul Ashall, 2008
Multiple units
W2
F1
P3
R4
E evaporator; C crystalliser; F filter unit F1 fresh feed; W2 evaporated P3 solid product; R4 recycle Paulwater; Ashall, 2008 of saturated solution from filter unit
Exercise
A mass balance and tracking of usage of a solvent used in an API production process is required for a Pollution Emission Register (PER). Discuss and outline in general terms how you would do this.
Ref. www.epa.ie
Paul Ashall, 2008
Definitions
Stoichiometric quantities Limiting reactant Excess reactant Conversion Yield Selectivity Extent of reaction
Paul Ashall, 2008
Stoichiometry
Refers to quantities of reactants and products in a balanced chemical reaction. aA + bB cC + dD i.e. a moles of A react with b moles of B to give c moles of C and d moles of D. a,b,c,d are stoichiometric quantities
continued
A reactant is in excess if it is present in a quantity greater than its stoichiometric proportion. % excess = [(moles supplied stoichiometric moles)/stoichiometric moles] x 100
Conversion
Fractional conversion = amount reactant consumed/amount reactant supplied % conversion = fractional conversion x 100
Note: conversion may apply to single pass reactor conversion or overall process conversion
Paul Ashall, 2008
Yield
Yield = (moles product/moles limiting reactant supplied) x s.f. x 100
Where s.f. is the stoichiometric factor = stoichiometric moles reactant required per mole product
Selectivity
Selectivity = (moles product/moles reactant converted) x s.f. x100
OR Selectivity = moles desired product/moles byproduct
Extent
Extent of reaction = (moles of component leaving reactor moles of component entering reactor)/stoichiometric coefficient of component
Note: the stoichiometric coefficient of a component in a chemical reaction is the no. of moles in the balanced chemical equation ( -ve for reactants and +ve for products)
Paul Ashall, 2008
Examples
A B i.e. stoichiometric coefficients a = 1; b = 1 100 kmol fresh feed A; 90 % single pass conversion in reactor; unreacted A is separated and recycled and therefore overall process conversion is 100%
R F
reactor
separation
Paul Ashall, 2008
References
Elementary Principles of Chemical Processes, R. M. Felder and R. W. Rousseau, 3rd edition, John Wiley, 2000