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  • Pathology of Diabetic Ketoacidosis - Romeo Rivera Jr.

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    discussed in thios schematic presentation are the stages in the process of diabetic type 1 process including the disease nature and possible complications. though not so comprehensive enough to tackle all possible complications, this presentation give enough insight of the disease process.

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    discussed in thios schematic presentation are the stages in the process of diabetic type 1 process including the disease nature and possible complications. though not so comprehensive enough to tackle all possible complications, this presentation give enough insight of the disease process.

    Copyright:

    Attribution ShareAlike (BY-SA)
    Download as DOC, PDF, TXT or read online from Scribd
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    1K views1 page

    Pathology of Diabetic Ketoacidosis - Romeo Rivera Jr.

    Uploaded by

    romeo rivera
    discussed in thios schematic presentation are the stages in the process of diabetic type 1 process including the disease nature and possible complications. though not so comprehensive enough to tackle all possible complications, this presentation give enough insight of the disease process.

    Copyright:

    Attribution ShareAlike (BY-SA)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    PATHOPYSIOLOGY OF TYPE 1 DM & DKA

    Stage I Stage II Stage III


    Genetic Predisposition Environmental Trigger Active Auto Immunity
    n

    Stage IV
    Acute Illness / Stress Progressive Beta Cell
    Destruction

    Increased Insulin Consumption Fasting Hyperglycemia Decrease 1st Phase


    Insulin Secretion

    Honeymoon Period

    Mass Destruction of
    Alpha & Beta Cells Reached
    80% - 90%

    Stage IV
    Insulin Resistance Insulin Deficiency Proinsulin
    Overt Diabetes Mellitus Secretion
    Glucagon, Cathecholaines
    & Grwoth Hormone Decreased Tissue Response Decreased Glucose Induced
    to Insulin Insulin Secretion Protein Wasting

    Decreased Cellular Glucose Muscle Wasting


    Hyperglycemia Increased Hepatic Glucose
    Uptake
    Production
    Weight Loss &
    Peripheral Insulin Post Receptor Weakness
    Energy Production Glycolysis Impaired Beta
    Resistance Defect
    From Fat Stores Gluconeogenesis Cell Function
    Fatigue
    Lipolysis
    Further Increase in Bld.
    Glucose Polyphagia
    Ketosis
    Acid Base DKA Lungs
    Imbalace
    Glycosuria
    Kidney Acetone Breath
    Acidosis & Kussmaul’s
    Breathing
    Ketonuria Osmotic Diuresis Severe K loss
    Acid Overload
    Na Excretion
    Hemoconcentration Polyuria
    Diabetic Coma

    Tissue Anoxia Fluid Volume Deficit polydipsia

    Death

    Lactic Acid Hypovolemic Shock Hypotension


    Production

    Tachycardia

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