Brand Name: Somazine

Generic Name: Citicoline

Indications: CVD in acute and recovery phase, symptoms and signs of cerebral
insufficiency e.g. dizziness, memory loss, poor conc., disorientation recent
cranial.
Drug Classification: CNS stimulants
Mechanism of action: Citicoline increases the neurotransmission levels because it favors
the synthesis andf production speed of dopamine in the striatum, acting then as
dopominergic agonist through the inhibition of tyrosine hydroxilase. Citicoline
behaves like a presypnatic cholinergic agent in favoring the synthesis of
acetylcholine. Citicoline improves the neuronal metabolism in those cases
where there is neuronal deterioration due to degenerative, toxic or ischemic
cause.
Dosage: Adult oral drops: 100-200 mg (I-2mL) bid or tid.
Special Precaution: Must not be administered along with medications containing
meclofenoxate (aka clophenoxate).
Pregnancy Risk Category:
Adverse reaction: GI disorders
Contraindication: Must not be administered to patients with hypertonia.
Form: Oral drops, injections.
Nursing Responsibilities:
 Medication should be administered at least 6 hours before bed time to minimize
sleep disturbances.
 Make sure that the contents of other medication to be administered doesn’t
contain meclofenoxate.
 Monitor the adverse reaction.
 Instruct patient not to alter dose without consulting a physician.
 Inform patient that the physician may order holidays from drug to assess
progress and decrease dependence.