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Handout On History of Genetics
Handout On History of Genetics
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HISTORY OF GENETICS
Prehistoric times
Domesticated plants and animals like Horses,
camels, oxens, and various breeds of dogs
during 8000-10000 B.C.
5000 B.C. Maize, wheat, rice, and date palm
were cultivated
Prehistoric evidence of cultivated plants and
animals documents our ancestors successful
attempts
to
manipulate
the
genetic
composition of useful species.
The Greek Influence
Hippocrates
An ancient Greek physician
Father of Medicine
Hippocratic treatise: On The Seed
Male semen is formed from different
parts of the body and is transported
through the blood vessels to the
testicles.
Active humors act as bearers of
hereditary traits and are drawn from
various parts of the body to the
semen
Aristotle
Naturalist and philisopher
He believed that male semen was formed
from blood not from each organ
That a generative heat resided in a vital
heat that has the capacity to produce
offspring of the same form as the parents
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Hermann Muller
X-rays cause mutations and gene
mutations alter normal developmental
pattern.
Richard Goldschmidt
Genes exist as points in a chromosome
and has to be arranged in a proper order
to control normal developmental process
of the eye
A. E. Garrod
THEORY OF INBORN ERRORS OF
METABOLISM
Certain metabolic diseases are
inherited and had Mendelian
basis.
Oswald Avery
Genes are composed of a specific nucleic
acid DNA
Edward Lawrie Tatum and George Wells
Beadle
Genes code for protein
ONE-GENE-ONE-ENZYME
HYPOTHESIS
Oswald Avery, Maclyn McCarty, C. M.
MacLeod
Isolated DNA as the genetic material
(then called the transforming principle)
Erwin Chargaff
showed that the four nucleotides are not
present in nucleic acids in stable
proportions, but that some general rules
appear to hold (e.g., that the amount of
adenine, A, tends to be equal to that of
thymine, T).
Hershey-Chase Experiment
1952: proves the genetic information of
phages (and all other organisms) to be
DNA
James Watson and Francis Crick
Molecular structure of DNA.
Messelson-Stahl Experiment
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APPLICATIONS
Plant and Animal Improvement
Medicine
Genetic Engineering
Genetic Counselling
Legal Applications
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APPROACHES TO GENETICS
TRANSMISSION GENETICS
Patterns of inheritance of traits are examined.
Experiments are designed so that the transmission of
traits from parents to offspring can be analyzed through
several generations
PEDIGREE ANALYSIS
tool used in transmission genetics
Leads to inferences concerning the mode of inheritance
of a particular trait
CYTOGENETICS
Study of chromosome structure and behavior during cell
division
Karyotype
- tool used in cytogenetics
- illustrates the chromosomes of any
species arranged in a standard
sequence
MOLECULAR GENETIC ANALYSIS
Includes information on the nature, expression,
replication, regulation of the genetic information.
Includes also determination of nucleotide sequences
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