STREPTOCCOCAL INFECTION ANTIBODY FORMATION ANTIGEN-ANTIBODY COMPLEX DEPOSIT IN GLOMERULUS ACUTE INFLAMMATION AND DAMAGE PERMEABILITY OF CAPILLARY

NON MODIFIABLE RISK FACTOR

GLOMERULUS SWELLING CONGESTION

CELL PROLIFERATION
MODIFIABLE RISK FACTORS

A./ H/0/1 23 G/!1/0

ACUTE GLOMERULONEPHRITIS LEADING TO CHORNIC GLOMERULONEPHRITIS REPEATED INFLAMMATION

D /2 N/4506267 !8 S/1/!2903 : ;/823:/

STAGE 1 GFR (>90 mL/m !/1"#$ m%&"ISCHEMIA' NEPHRON LOSS' SHRINKAGE OF KIDNEY
DEC" RENAL BLOOD FLOW DEC" RENAL RESER(E DAMAGE TO NEPHRONS

STAGE % GFR ()0-*9 mL/m !/1"#$ m%&" STAGE $ GFR ($0-+9 mL/m !/1"#$ m%&"

+0, DAMAGE >#+, DAMAGE RENAL INSUFFICIENCY REMAINING NEPHRONS UNDERGO CHANGES REMAINING NEPHRONS FILTER MORE SOLUTES

STAGE - GFR (1+-%9mL/m !/1"#$ m%&"

HYPERTROPHY OF REMAINING NEPHRONS FURTHER LOSS OF NEPHRON FUNCTIONS

LOSS OF NON EXCRETORY RENAL FUNCTION DISTURBANCE ! REPRODUCTION IMMUNE DISTURBANCES LIPID PRODUCTION IMPAIRED INSULIN ACTION ACTI(ATION OF (IT D FAILURE TO PRODUCE ERYTHROPOIETIN RBC PRODUCTION BUN HEMOGLOBIN

STAGE + ESRD
CALCIUM ABSORPTION HYPOCALCEMIA HYPERPARATHYROIDISM EDEMA HEART FAILURE HYPERTENSION

LOSS OF EXCRETORY RENAL FUNCTION PHOSPHATE EXCRETION POTASSIUM EXCRETION HYDYOGEN EXCRETION SODIUM REABSORTION IN TUBULE

HYPERPHOSPHATEMIA HYPERKALEMIA METABOLIC ACIDOSIS WATER RETENTION

EXCRETION OF NITROGENOUS WASTE

URIC ACID CREATININE

PERIPHERAL NER(E CHANGES

CNS CHANGES

BLEEDING TENDENCIES ALTERED TASTE

PRURITUS ANEMIA PALLOR FATIGUE PROTEINURIA PERICARDITIS