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  • Antitumor Antibiotics and Chemotherapies Guide

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    This document summarizes several antitumor antibiotics, including their typical dosages, schedules of administration, and common side effects. Some of the main drugs discussed are bleomycin, doxorubicin, irinotecan, and topotecan. Side effects often involve the blood (myelosuppression), gastrointestinal tract (nausea, mucositis), and skin (alopecia). Dosage reductions may be needed in cases of renal impairment or other organ dysfunction. Drug interactions and schedule dependencies are also noted for several of the antitumor antibiotics.

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    chemo

    Original Title

    Antitumor Antibiotics

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    This document summarizes several antitumor antibiotics, including their typical dosages, schedules of administration, and common side effects. Some of the main drugs discussed are bleomycin, doxorubicin, irinotecan, and topotecan. Side effects often involve the blood (myelosuppression), gastrointestinal tract (nausea, mucositis), and skin (alopecia). Dosage reductions may be needed in cases of renal impairment or other organ dysfunction. Drug interactions and schedule dependencies are also noted for several of the antitumor antibiotics.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    15 views3 pages

    Antitumor Antibiotics and Chemotherapies Guide

    Uploaded by

    docbin
    This document summarizes several antitumor antibiotics, including their typical dosages, schedules of administration, and common side effects. Some of the main drugs discussed are bleomycin, doxorubicin, irinotecan, and topotecan. Side effects often involve the blood (myelosuppression), gastrointestinal tract (nausea, mucositis), and skin (alopecia). Dosage reductions may be needed in cases of renal impairment or other organ dysfunction. Drug interactions and schedule dependencies are also noted for several of the antitumor antibiotics.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 3

    Antitumor

    antibiotics

    Bleomycin 1525 mg/d qd x5 IV
    bolus or continuous
    IV
    Pulmonary
    Skin effects
    aynaud!s
    "y#ersensiti$ity
    Inacti$ate by bleomycin
    %ydrolase &decreased in
    lung/skin'
    (2 en%ances #ulmonary
    toxicity
    )is#latin*induced
    decrease in )r)l may
    increase skin/lung
    toxicity
    educe dose if )r)l + ,-
    m./min
    /ctinomycin 0
    1-15 g/kg #er
    day qd x5 IV bolus
    1arro2
    3ausea
    1ucositis
    Vesicant
    /lo#ecia
    adiation recall
    1itomycin ) ,1- mg/m
    2
    q,
    2eeks

    1arro2
    Vesicant
    "emolytic*uremic syndrome
    .ung
    )V4%eart failure
    5reat su#erficial bladder
    cancers by intra$esical
    infusion
    0elayed marro2 toxicity
    )umulati$e marro2
    toxicity
    6to#oside
    &VP1,*217'
    1--15- mg/m
    2
    IV
    qd x75d
    or 5- mg/m
    2
    P( qd
    x21d
    or u# to 15-- mg/m
    2

    #er dose &%ig% dose
    2it% stem cell
    su##ort'
    1arro2 &8B)s 9 #latelet'
    /lo#ecia
    "y#otension
    "y#ersensiti$ity &ra#id IV'
    3ausea
    1ucositis &%ig% dose'
    "e#atic metabolism4
    renal 7-:
    educe doses 2it% renal
    failure
    Sc%edule*de#endant &5
    day better t%an 1 day'
    .ate leukemogenic
    /ccentuate antimetabolite
    action
    5o#otecan 2- mg/m
    2
    IV q7;
    2eeks o$er 7- min
    or 1<57 mg/m
    2
    q7;
    2eeks o$er 2; %
    or -<5 mg/m
    2
    #er day
    o$er 21 days
    1arro2
    1ucositis
    3ausea
    1ild alo#ecia
    educe dose 2it% renal
    failure
    3o li$er toxicity
    Irinotecan &)P5
    II'
    1--15- mg/m
    2
    IV
    o$er =- min q7;
    2eeks
    or 7- mg/m
    2
    #er day
    o$er 12- %
    0iarr%ea> ?early onset? 2it%
    cram#ing@ flus%ing@ $omitingA
    ?late onset? after se$eral
    doses
    1arro2
    /lo#ecia
    3ausea
    Vomiting
    Pulmonary
    Prodrug requires
    enBymatic clearance to
    acti$e drug ?S3 7C?
    6arly diarr%ea likely due
    to biliary excretion
    .ate diarr%ea@ use ?%ig%*
    dose? lo#eramide &2 mg
    q2; %'
    0oxorubicin and
    daunorubicin
    ;5,- mg/m
    2
    dose
    q7; 2eeks
    or 1-7- mg/m
    2
    dose
    q 2eek
    or continuous*
    infusion regimen
    1arro2
    1ucositis
    /lo#ecia
    )ardio$ascular acute/c%ronic
    Vesicant
    "e#arin aggregateA
    coadministration
    increases clearance
    /cetamino#%en@ B)3D
    increase li$er toxicity
    adiation recall
    Idarubicin 1-15 mg/m
    2
    IV q 7
    2eeks
    or 1- mg/m
    2
    IV qd
    x7
    1arro2
    )ardiac &less t%an
    doxorubicin'
    3one establis%ed
    6#irubicin 15- mg/m
    2
    IV q7
    2eeks

    1arro2
    )ardiac
    3one establis%ed
    1itoxantrone 12 mg/m
    2
    qd x7
    or 121; mg/m
    2
    q7
    2eeks
    1arro2
    )ardiac &less t%an
    Interacts 2it% %e#arin
    .ess alo#ecia@ nausea
    doxorubicin'
    Vesicant &mild'
    Blue urine@ sclerae@ nails
    t%an doxorubicin
    adiation recall

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