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Background to Tissuemed
• Tissuemed is a prominent medical device company based in Leeds, UK
⇒Tissuepatch3
is a sealant and barrier film for the adjunctive prevention of air, blood
and/or fluid leakage in thoracic and general surgery
⇒Tissuepatch3
⇒Tissuepatch3
• Highly versatile
• Thoracic
• General
Tiss uemed Op in io n:
Tiss uep atch 2 has p ro ven ef ficacy and safety .
Tiss uep atch 3 is e xp ected to maxi mise al read y ver y sub stant ial comp etitive a dvantag es
Clinical performance – Tissuepatch2
• Patients to be treated - 20
Baxter Tisseel Liquid £200 Human/Animal Preparation Time – 15-20 mins*** Low(Strength) Haemostat action
Application Time – 1-2 mins greater than
sealant effect
CSL Behring Beriplast Liquid £200 Human/Animal Preparation Time – 15-20 mins*** Low(Strength) Haemostat action
/Nycomed Application Time – 1-2 mins greater than
sealant effect
Ethicon/Omrix Quixil/ Liquid £200 Human Preparation Time – 15-20 mins*** Low(Strength) Haemostat action
Crosseal Application Time – 1-2 mins greater than
sealant effect
CryoLife BioGlue Liquid £190 Animal Preparation Time – 2-3 mins Low(Weak adhesion) Cytotoxicity
Application Time – 1-2 mins concerns relating
to glutaraldehyde
component
Nycomed Tachosil / Sheet £209 Human/Animal Preparation Time – 2-3 mins ** Medium(Slow/Weak adhesion) Poor surface-
Tachocomb Application Time – 3-5 mins ** conformance
Thermogenesis CryoSeal Liquid £160 Autologous Preparation Time – 60 mins** Low(Strength) Requires
Application Time – 1-2 mins** processing unit to
convert patients
blood to product
Vivolution Vivostat Liquid £160 Autologous Preparation Time – 30 mins** Low(Strength) As CryoSeal
Application Time – 1-2 mins**
Confluent DuraSeal Liquid £220 Synthetic Preparation Time – 1-2 mins Low(Strength,Short duration)
Surgical Application Time – 1-2 mins
Genzyme FocalSeal Liquid £180 Synthetic Preparation Time – 2-4 mins*** Low(Strength/Short duration) Requires light
Application Time – 5-10 mins source
Tissuemed Tissuepatch3 Film £200 Synthetic Preparation Time – 0 mins High (Contact surface
Application Time – 30 secs/patch chemistry, duration of effect)
All liquid sealants require applicators or spray systems…..prices not included as this may be provided Free of Charge
General comment: Unlike Tissuepatch3 none of the listed products, excluding FocalSeal, was originated based on the lung application, which explains their
generally low acceptance.
Fibrin-based Liquids(Tisseel, Beriplast, Quixil)
•Need time to apply (Focalseal – 5-10 minutes) and work (1-2 minutes)
Is Tissuepatch3 biodegradable?
Tissuepatch3 remains in position covered in a thin fibrous cover and it slowly
degrades until resorbed in ≈ 50 days.
In conclusion…..a few soundbites