PARAMYXOVIRIDAE

PETER H. RUSSELL, BVSc,

PhD, FRCPath, MRCVS
Department of Pathology and
Infectious Diseases, The Royal
Veterinary College,
Royal College Street,
London NW1 OTU.
E-mail Web site
 Objective
Students should be able to:
• describe the importance of fusion
protein for virus penetration and
vaccination.
• realise that respiratory syncytial virus is
still a primary virus of calf pneumonia
• describe how distemper virus causes
disease in dogs and how it is controlled.
Introduction:
Classification:

3 Genera:
Paramyxovirus;
Pneumoviruses;
Morbilliviruses.
Structure:
Cultivation and cytopathic
effect:
HA in eggs, syncytia in tissue
culture.
Cell tropism in vivo:
Genus PARAMYXOVIRUS

NEWCASTLE DISEASE VIRUS,

(AVIAN PARAMYXOVIRUS 1)
 MURINE
PARAINFLUENZA‑1
(SENDAI VIRUS)
BOVINE PARAINFLUENZA ‑3
(PI ‑3)
BOVINE PARAINFLUENZA ‑3
(PI ‑3)

(cont.)
PARAINFLUENZA‑5 (PI‑5)
 Genus

PNEUMOVIRUS,BOVINE
RESPIRATORY SYNCYTIAL
VIRUS (BRSV)
 Genus

PNEUMOVIRUS,BOVINE
RESPIRATORY SYNCYTIAL
VIRUS (BRSV)

(cont.)
Genus MORBILLIVIRUS

DISTEMPER VIRUS (CDV)

Genus MORBILLIVIRUS

DISTEMPER VIRUS (CDV)

(cont.)
Genus MORBILLIVIRUS

DISTEMPER VIRUS (CDV)

(cont.)
RINDERPEST

(Cattle plague)
RINDERPEST

(Cattle plague)

(cont.)
PESTE DE PETIT
RUMINANT
EQUID PARAMYXOVIRUS

( alias Hendra virus; Hendra is a

suburb of Brisbane)
NIPAH VIRUS
 Summary
3 genera of paramyxoviridae occur : para-, morbilli- and pneumo- viruses
The isolates are monotypic because they have an unsegmented genome and conserved antigens
on the fusion protein.
NDV is a serious notifiable disease of poultry.
BRSV is the most common cause of calf pneumonia. Vaccines limit disease but do not prevent
infection and some exacerbate disease by immune complex disease.
CDV was the major pathogen of dogs but has been controlled in the UK by vaccination.
A variety of unexpected infections of man and wildlife have occurred.