ANTIDEPRESSANTS

SSRI Fluoxetine
SSNRI Venlafaxine
TCA (block NE reuptake) Amitriptyline
5HT2 Antagonists Trazodone
Unicycline Bupropion
Tetracycline Mirtazapine
MAOIs Phenelzine
Mood Stabilizer Lithium
Schizophrenia - mixed inc/dec DA
inc DA mesolimbic
dec DA mesocortical
dec DA mesostriatal
ANTIPSYCHOTICS
Typical Haloperidol (Haldol)
Atypical Clozapine
Olanzapine
Ziprasidone
Aripiprazole (Abilify)
ANXIOLYTICS/SEDATIVES/HYPNOTICS
Benzodiazepine
positive allosteric modulator of
GABAaR
Barbituates
GABA-mimetic at high conc,
inhibit glutamate
Chloral hydrate
opens GABAa, glycine, K+
channels, inhibits glutamate R
Buspirion 5HT1aR partial agonist
Hydroxyzine, Diphenhydramine H1R Antagonist
most common, dec libido
effective for chronic pain, fewer drug intxns
lethal in overdose, met acido Imipramine for enuresis (bed wetting)
highly sedating Nefazodone: lethal hepatic failure
no dec libido, dec nicotine cravings
refractory cases, no dec libido
rarely used, only refractory rxn w/ tyramine in wine and food can cause HT crisis
bipolar disorder, dec IP3 diuretics inc litium plasma conc
positive sx
negative sx
parkinsonian sx "acting on the Striatal pathway will cause Skeletal muscle problems"
full antagonist at D2R extrapyramidal sx, tardive dyskinesia, sex dysfunc
anatonist/partial agonist at D2/5HTR weight gain, long QT, DIABETES, cataracts
major weight gain problem
hypotension and prolonged QT
also used for major depression
all cross placenta - don't given when preg
more addictive
potential/dependence
inc prophyrin (contrind in
porphyria pts)
oral sedative for children in dentistry "used for CHiL d ORAL surgery"
antianxiety
"different from BuPropion (for
depression), BuSprione helps
when you're Scared (or anxious)"
in Benadryl, enhances sedation
Imipramine for enuresis (bed wetting)
rxn w/ tyramine in wine and food can cause HT crisis
"acting on the Striatal pathway will cause Skeletal muscle problems"
extrapyramidal sx, tardive dyskinesia, sex dysfunc
weight gain, long QT, DIABETES, cataracts