AminoAcids

Stu
pKa
Carboxyl:1.82.5
Amino:8.710.7

Essen<al:
9aa

Rgroupuniquenames
8aa

RgrouppKa:
7aa

Glycine
Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.

Glycine
Structure:

1leEer:[G]
3leEer:(Gly)
RGrouppKa:N/A
Requirement:Nonessen<al
Other:
1.Notchiral;onlyop<callyinac<veAA
2.Alipha<c

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.

Alanine

 Structure:

Alanine

1leEer:[A]
3leEer:(Ala)
RGrouppKa:N/A
Requirement:Nonessen<al
Other:
1.Alipha<c

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.

Valine

 Structure:

Valine

1leEer:[V]
3leEer:(Val)
RGrouppKa:N/A
Requirement:Essen<al
Other:
1.Alipha<c
2.nonpolar

Leucine
Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.

Leucine
Structure:

1leEer:[L]
3leEer:(Leu)
RGrouppKa:N/A
Requirement:Essen<al
Other:
1.Alipha<c

Isoleucine
Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.

Isoleucine
Structure:

1leEer:[I]
3leEer:(lle)
RGrouppKa:N/A
Requirement:Essen<al
Other:

1.Alipha<c
2.Twochiralcarbons,twosetsenan<omers(Isoleucine,
Alloisoleucine)

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.

Proline

 Structure:

Proline

1leEer:[P]
3leEer:(Pro)
RGrouppKa:N/A
Requirement:Nonessen<al
Other:

1.Alipha<cringsystemwithaNitrogen
2.Theheterocyclicpyrrolidineringrestrictsthegeometryof
polypep<des;helixbreaker

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.

Phenylalanine

 Structure:

Phenylalanine

1leEer:[F]
3leEer:(Phe)
RGrouppKa:N/A
Requirement:Essen<al
Other:

1.Aroma<cRgroup(Benzene)
2.OD260nm

Tyrosine
Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.

Tyrosine
Structure:

1leEer:[Y]
3leEer:(Tyr)
RGrouppKa:10.5
Requirement:Nonessen<al
Other:
1.Aroma<cRgroup(Phenol)
2.OD280nm

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.

Tryptophan

 Structure:

Tryptophan

1leEer:[W]
3leEer:(Trp)
RGrouppKa:N/A
Requirement:Essen<al
Other:

1.Aroma<cRgroup(Indolegroup)
2.OD280nm

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.
3.

Cysteine

 Structure:

Cysteine

1leEer:[C]
3leEer:(Cys)
RGrouppKa:8.4
Requirement:Nonessen<al
Other:

1.SulfurRgroup
2.Twocysteinesidechainscanbecrosslinkedbyformingadisuldebridge(
CH2SSCH2)viaoxida<on(lossofanelectron)
3.Disuldebridgesmaystabilizethethreedimensionalstructuresofproteins
4.ONLYAAWHOSESIDECHAINCANFORMCOVALENTBONDS

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.

Methionine

 Structure:

Methionine

1leEer:[M]
3leEer:(Met)
RGrouppKa:N/A
Requirement:Essen<al
Other:
1.SulfurRgroup

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.

Serine

 Structure:

Serine

1leEer:[S]
3leEer:(Ser)
RGrouppKa:N/A
Requirement:Nonessen<al
Other:

1.AlcoholRgroup
2.Uncharged,polarsidechain

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.

Threonine

 Structure:

Threonine

1leEer:[T]
3leEer:(Thr)
RGrouppKa:N/A
Requirement:Essen<al
Other:

1.AlcoholRgroup
2.Uncharged,polarsidechain

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.
3.

Aspartate

 Structure:

Aspartate

1leEer:[D]
3leEer:(Asp)
RGrouppKa:3.9
Requirement:Nonessen<al
Other:

1.AcidicRgroup
2.Dicarboxylicacid
3.Nega<velychargedatpH7

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.
3.

Glutamate

 Structure:

Glutamate

1leEer:[E]
3leEer:(Glu)
RGrouppKa:4.1
Requirement:Nonessen<al
Other:

1.AcidicRgroup
2.Dicarboxylicacid
3.Nega<velychargedatpH7

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.

His<dine

 Structure:

His<dine

1leEer:[H]
3leEer:(His)
RGrouppKa:6.0
Requirement:Essen<al
Other:
1.BasicRgroup
2.Imidazolesidechain

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.
3.

Lysine

 Structure:

1leEer:[K]
3leEer:(Lys)
RGrouppKa:10.5
Requirement:Essen<al
Other:

Lysine

1.BasicRgroup
2.Alkylaminogroup
3.Sidegroupisnitrogenousbasethatissubstan<allyposi<velycharged
atpH7

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.
3.

Arginine

 Structure:

Arginine

1leEer:[R]
3leEer:(Arg)
RGrouppKa:12.5
Requirement:Nonessen<al
Other:

1.BasicRgroup
2.Guanidinogroup
3.Sidechainisnitrogenousbase,whichissubstan<allyposi<vely
chargedatpH7

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.

Glutamine

 Structure:

Glutamine

1leEer:[Q]
3leEer:(Gln)
RGrouppKa:N/A
Requirement:Nonessen<al
Other:
1.Amidederiva<veRgroup
2.Uncharged,highlypolar

 Structure:

1leEer:
3leEer:
RGrouppKa:
Requirement:
Other:
1.
2.

Asparagine

 Structure:

Asparagine

1leEer:[N]
3leEer:(Asn)
RGrouppKa:N/A
Requirement:Nonessen<al
Other:
1.Amidederiva<veRgroup
2.Uncharged,highlypolar