LABETOLOL HYDROCHLOIDS

Therapy aims is to slow the progression the

disorder and permit continuation of
pregnancy.
The maternal benefit has to be balanced
against the risk of reducing the placental
perfusion
The treatment reduces the risk of sudden
increase in BP leading to arterial damage
with the possibility of cerebral haemorrhage
or hypertensive encephalopathy.


Nama Dagang:- Tolbetolol
Nama Generik:- Labetolol Hydrochloids
Dos :- 100 mg/tablet
Cara Pengambilan :- Oral.
Tindakan :- Beta-adrenergic blocking
agen untuk mengurangkan cardia
output dan block peripheral
adrenoceptors.



Indikasi :- Anti-Hypertensive.
Kontraindikasi :- Prolong
hypotension, second or third degree
heart block,cardiogenic shock,dan
severe body cardia, asthma
bronchitis, kidney disease, lever
disease, mental depression,
overactive thyroid, diabetes mellitus.


1 ampule = 25mg/5ml
Rapid control :-
1. Give 1 ampoule slow bolus.
2. Can repeat every 20/min up to
maximum of 2 doses, if Diastolic BP
110 mg, to start infusion.
a.) Via infusion syringe pump :-
1.) 50 mg (2 amp = 10 mls) + 40 ml
normal saline = 1 mls / 1 mg.
2.) Start at 20 mls / hour (20 mg /
hour)
3.) Increase every 30 minutes by 20
mls up to maximum of 160 mls /
hour.

b.) Via IV Drip Infusion :-

1.) 200 mg (8 amp = 40 mls) + 160 mls
normal saline = 1 mls / 1 mg.
2.) Start at 20 mls/hour (20 mg/hour)
3.) Increase every 30 minutes by 20 mls
up to maximum of 160 mls / hour.

Dizziness, mental changes,
drowsiness, fatigue, headache,
catatonia, depression, anxiety,
nightmares, paresthesias, lethargy.
a) Acute Hypertension Crisis :-
- Systolic BP 180 mmHg.
- Diastolic BP 110 mmHg.
- Mean arterial pressure 125 mmHg.

b) Persistent Hypertension :-
- BP 160/100 mmHg.


Acute HPT crisis :-
1. IV Labetolol
2. IV Hydralazine
3. IV GTN






Persistent HPT :-
1. Tablet Labetolol
2. Tablet Methyldopa
3. Tablet Nifedipine.