Physical Therapy For Bell S Palsy (Idiopathic Facial Paralysis) (Review)

Physical therapy for Bell s palsy (idiopathic facial paralysis)
(Review)
Teixeira LJ, Soares BGDO, Vieira VP, Prado GF
This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library
2008, Issue 3
http://www.thecochranelibrary.com
Physical therapy for Bell s palsy (idiopathic facial paralysis) (Review)
Copyright 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
T A B L E O F C O N T E N T S
1 HEADER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1 ABSTRACT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2 PLAIN LANGUAGE SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2 BACKGROUND . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3 OBJECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3 METHODS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
4 RESULTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
8 DISCUSSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
9 AUTHORS CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
9 ACKNOWLEDGEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
9 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
12 CHARACTERISTICS OF STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
23 DATA AND ANALYSES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Analysis 1.1. Comparison 1 ELECTROSTIMULATION VERSUS CONTROL, Outcome 1 Incomplete recovery after 6
and 12 months. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Analysis 1.2. Comparison 1 ELECTROSTIMULATION VERSUS CONTROL, Outcome 2 Mean Facial Grading Scale
after 3 months. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Analysis 2.1. Comparison 2 ELECTROSTIMULATION VERSUS PREDNISONE, Outcome 1 Incomplete recovery
after six months (all participants). . . . . . . . . . . . . . . . . . . . . . . . . . . . 26
Analysis 2.2. Comparison 2 ELECTROSTIMULATION VERSUS PREDNISONE, Outcome 2 Incomplete recovery six
months according severity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26
Analysis 2.3. Comparison 2 ELECTROSTIMULATION VERSUS PREDNISONE, Outcome 3 Mean time to complete
recovery (in days). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
Analysis 3.1. Comparison 3 EXERCISE VERSUS WAITING LIST, Outcome 1 Recovery on Facial Grading Scale
(Sunnybrook scale). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27
Analysis 3.2. Comparison 3 EXERCISE VERSUS WAITING LIST, Outcome 2 Recovery on Facial Disability Index-
physical. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28
Analysis 4.1. Comparison 4 EXERCISE VERSUS CONVENTIONAL TREATMENT, Outcome 1 Incomplete recovery
three months after randomisation. . . . . . . . . . . . . . . . . . . . . . . . . . . . 28
Analysis 4.2. Comparison 4 EXERCISE VERSUS CONVENTIONAL TREATMENT, Outcome 2 Mean time from the
beginning of the recovery (in weeks). . . . . . . . . . . . . . . . . . . . . . . . . . . 29
Analysis 4.3. Comparison 4 EXERCISE VERSUS CONVENTIONAL TREATMENT, Outcome 3 Mean time from
completion of recovery (in weeks). . . . . . . . . . . . . . . . . . . . . . . . . . . . 30
Analysis 4.4. Comparison 4 EXERCISE VERSUS CONVENTIONAL TREATMENT, Outcome 4 Potmann Score. 30
30 APPENDICES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
35 HISTORY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
35 CONTRIBUTIONS OF AUTHORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
35 DECLARATIONS OF INTEREST . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
35 INDEX TERMS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
i Physical therapy for Bell s palsy (idiopathic facial paralysis) (Review)
[Intervention Review]
Physical therapy for Bell s palsy (idiopathic facial paralysis)
Lzaro Juliano Teixeira
1
, Bernardo Garcia de Oliveira Soares
2
, Vanessa Pedrosa Vieira
3
, Gilmar F Prado
4
1
Department of Physiotherapy, Prefeitura Municipal de Balneario Camboriu, Santa Catarina, Brazil.
2
Universidade Federal de So
Paulo, So Paulo, Brazil.
3
Medicina Interna e teraputica, UNIFESP - Universidade Federal de So Paulo, So Paulo, Brazil.
4
So Paulo,
Brazil
Contact address: Lzaro Juliano Teixeira, Department of Physiotherapy, Prefeitura Municipal de Balneario Camboriu, R. Ana Garcia
Pereira, n 167, Balneario Camboriu, Santa Catarina, 88340-000, Brazil. lazarojt@terra.com.br.
Editorial group: Cochrane Neuromuscular Disease Group.
Publication status and date: New, published in Issue 3, 2008.
Review content assessed as up-to-date: 3 February 2008.
Citation: Teixeira LJ, Soares BGDO, Vieira VP, Prado GF. Physical therapy for Bell s palsy (idiopathic facial paralysis). Cochrane
Database of Systematic Reviews 2008, Issue 3. Art. No.: CD006283. DOI: 10.1002/14651858.CD006283.pub2.
A B S T R A C T
Background
Bells palsy (idiopathic facial paralysis) is commonly treated by physical therapy services with various therapeutic strategies and devices.
There are many questions about their efcacy and effectiveness.
Objectives
To evaluate the efcacy of physical therapies on the outcome of Bells palsy.
Search strategy
We searched the Cochrane Neuromuscular Disease Group Trials Register (February 2008), the Cochrane Central Register of Controlled
Trials (The Cochrane Library, Issue 4, 2007), MEDLINE (January 1966 to February 2008), EMBASE (January 1980 to February
2008), LILACS (January 1982 to February 2008), PEDro (from 1929 to February 2008), and CINAHL (January 1982 to February
2008).
Selection criteria
We selected randomised or quasi-randomised controlled trials involving any physical therapy. We included participants of any age with
a diagnosis of Bells palsy and all degrees of severity. The outcome measures were: incomplete recovery six months after randomisation,
motor synkinesis, crocodile tears or facial spasmsix months after onset, incomplete recovery after one year and adverse effects attributable
to the intervention.
Data collection and analysis
Titles and abstracts identied from the register were scrutinized. The assessment of methodological quality took into account secure
method of randomisation, allocation concealment, observer blinding, patient blinding, differences at baseline of the experimental
groups, and completeness of follow-up. Data were extracted using a specially constructed data extraction form. Separate subgroup
analyses of participants with more and less severe disability were undertaken.
1 Physical therapy for Bell s palsy (idiopathic facial paralysis) (Review)
Main results
The search identied 45 potentially relevant articles. Six studies met the inclusion criteria. Three trials studied the efcacy of electros-
timulation (294 participants) and three exercises (253 participants). Neither treatment produced signicantly more improvement than
the control treatment or no treatment.
There was limited evidence that improvement began earlier in the exercise group.
Authors conclusions
There is no evidence of signicant benet or harm from any physical therapy for idiopathic facial paralysis. The possibility that facial
exercise reduces time to recover and sequelae needs conrming with good quality randomised controlled trials.
P L A I N L A N G U A G E S U M M A R Y
Physical treatments for idiopathic facial paralysis
Bells palsy is an acute disorder of the facial nerve, which produces full or partial loss of movement on one side of the face. The facial
palsy gets completely better without treatment in most, but not all, people. Physical therapies, such as exercise, biofeedback, laser,
electrotherapy, massage and thermotherapy, are used to hasten recovery. This review of existing trials found insufcient evidence to
decide whether any of these therapies work. More trials are needed to assess their effects.
B A C K G R O U N D
Idiopathic facial palsy, also called Bells palsy, is an acute disorder
of the facial nerve, which may begin with symptoms of pain in the
mastoid region and produce full or partial paralysis of movement
of one side of the face (Adour 1982; Valena 2001). Its cause is
not known (Peitersen 2002). Increasing evidence suggests that the
main cause of Bells palsy is reactivation of latent herpes simplex
virus type 1 in the cranial nerve ganglia (De Diego 1999; Holland
2004; Valena 2001). How the virus damages the facial nerve is
uncertain (Gilden 2004).
The annual incidence of Bells palsy varies widely, ranging between
11.5 and 40.2 cases per 100,000 population (De Diego 1999;
Peitersen 2002). There are peaks of incidence in the 30 to 50 and
60 to 70 year old age groups (Gilden 2004; Gonalvez 1997).
Bells palsy has a fair prognosis without treatment (Holland 2004).
According to Peitersen (Peitersen 2002), complete recovery was
observed in 71% of all patients. Ninety-four per cent of patients
with incomplete and 61% with complete paralysis made a com-
plete recovery. The main question is whether results would be bet-
ter if some treatment were given.
About 23% of people with Bells palsy are left with either moder-
ate to severe symptoms, hemifacial spasm, partial motor recovery,
crocodile tears (tears upon salivation), contracture or synkinesis
(involuntary twitching of the face or blinking). Recurrence occurs
in about 8.3% (Valena 2001).
The prognosis depends to a great extent on the time at which re-
covery begins. Early recovery gives a good prognosis and late re-
covery a bad prognosis. If recovery begins within one week, 88%
obtain full recovery, within one to two weeks 83% and within
two to three weeks 61%. Normal taste, stapedius reex and tear-
ing give a signicantly better prognosis than if these functions are
impaired. Recovery is less likely to be satisfactory with complete
rather than incomplete paralysis, with pain behind the ear and in
older people (Danielidis 1999). Other poor prognostic factors in-
clude hypertension and diabetes mellitus (Gilden 2004; Peitersen
2002).
Evaluation of therapy is made difcult because of the high rates of
spontaneous and complete recovery (Peitersen 2002). The princi-
ples of treatment in the acute phase have not changed over the past
20 years (Adour 1982). They focus on protection of the cornea
fromdrying and abrasion due to impaired lid closure and tear pro-
duction. Lubricating drops are recommended during the day and
a simple eye ointment at night (Holland 2004; Valena 2001).
Cochrane reviews concluded that the available evidence did not
show signicant benet from acyclovir or similar agents (Allen
2004), steroid therapy (Salinas 2004) or acupuncture (He 2007).
However the Sullivan 2007 study with 496 participants compared
different combinations of prednisolone, acyclovir and placebo.
They found signicant benet from prednisolone but not acy-
clovir. Hato 2007 assessed the efcacy of valacyclovir with 296 par-
ticipants divided into two groups (valacyclovir with prednisolone,
and placebo with prednisolone) and found signicant benet from
valacyclovir.
Some authors suggest that facial nerve decompression be consid-
ered, although there are no data from clinical trials to support its
use (Adour 2002; Gilden 2004; Grogan 2001; Peitersen 2002).
Thermal methods, electrotherapy (which uses an electrical current
to cause a single muscle or group of muscles to contract), massage,
facial exercises and biofeedback are forms of physical therapy that
have been used (Mosforth 1958; Peitersen 2002). Exercise therapy
has been used more than other interventions (Beurskens 2003;
Brach 1999; Ross 1991; Segal 1995a).
Inthe last fewyears other systematic reviews have beenundertaken.
Beurskens 2004 searched electronic databases and included two
studies (Ross 1991; Segal 1995a) which did not show a signicant
effect of intervention. Quinn 2003 searched for electrotherapy
interventions in electronic databases, reference lists in the studies
andcontactedexperts from1975to2002. They concludedthat the
benet of electrotherapy was unclear due to inadequate research
methods, sample sizes and dose information. Despite this, they
provide a very good discussion about the current knowledge of
the anatomy, physiology and pathomechanics during the course
of the palsy to support the use of physiotherapy resources. None
of the trials considered in these reviews fullled the criteria for this
review.
Peitersen 2002 also highlighted the lack of evidence for current
treatments, for thermal methods (conductive, radiative and con-
vective heat transfer in order to achieve vasodilatation or ice over
the mastoid region with the aim of relieving oedema), electrother-
apy, massage and facial exercise.
O B J E C T I V E S
The objective of this systematic review was to evaluate the efcacy
of physical therapies for Bells palsy (idiopathic facial palsy).
M E T H O D S
Criteria for considering studies for this review
Types of studies
We included all randomised or quasi-randomised (alternate or
other systematic allocation) controlled trials involving any physical
therapy compared with no treatment, placebo treatment, drug
treatment, acupuncture or other physical therapy interventions.
Types of participants
We included participants with a diagnosis of Bells palsy, dened
as idiopathic lower motor neuron facial palsy of sudden onset.
Participants of any age, and all degrees of severity were included.
People with facial palsy due to Ramsay-Hunt syndrome or other
recognised causes were not included.
Types of interventions
We included trials of any formof physical therapy treatment com-
pared with either no treatment or drugs or an alternative form
of non-drug treatment. Physical therapy was considered as the
use in treatment of any physical agents, such as heat, light, cold,
sound, water, electricity, manual therapy and other gadgets work-
ing on physical principles. Types of physical therapy interven-
tions for facial palsy included facial exercises, such as strengthening
and stretching, endurance, therapeutic and facial mimic exercises
(mime therapy) (Beurskens 2003), electrotherapy, biofeedback,
transcutaneous electrical nerve stimulation (TENS) or electrical
neural muscular stimulation (ENMS), thermal methods or mas-
sage, alone or in combination with any other therapy.
Types of outcome measures
The primary outcome measure was incomplete recovery six
months after randomisation. Incomplete recovery was dened in
two ways. Participants who had House Grade III (moderate dys-
function) or worse (House 1985) at entry were considered to have
incomplete recovery if they still had House Grade III or worse.
For participants who had House Grade II at entry, incomplete
recovery was dened as a persistent House Grade II or worse after
six months. If the House Grade score was not available, another
similar facial nerve disability score was used instead (House 1985;
VanSwearingen 1996).
Secondary outcome measures were:
1. the presence of motor synkinesis, contracture, hyperkinesia,
facial spasm or crocodile tears six months after onset;
2. complete or incomplete recovery after one year;
3. adverse effects attributable to the intervention such as pain
or worsening of condition.
Search methods for identication of studies
We searched the Cochrane Neuromuscular Disease Group Tri-
als Register in February 2008 using the terms Bells palsy or
idiopathic facial paralysis or facial palsy. We also searched the
Cochrane Central Register of Controlled Trials (The Cochrane
Library, Issue 4, 2007), MEDLINE (January 1966 to February
2008), EMBASE (January 1980 to February 2008), LILACS (Jan-
uary 1982 to February 2008), and CINAHL (January 1982 to
February 2008) and PEDro (from 1929 to February 2008).
Electronic searches
See Appendix 1, Appendix 2, Appendix 3, Appendix 4, Appendix
5.
Searching other resources
1. We checked references of all identied trials.
2. We contacted physical therapy companies in order to
obtain data on unpublished trials.
3. We contacted rst authors of all included trials for further
information or information regarding unpublished trials.
Data collection and analysis
Study selection
Two authors (LJT, VPV) scrutinized titles and abstracts identied
from the register. The full texts of all potentially relevant studies
were obtained for independent assessment by the authors. Two
authors decided which trials tted the inclusion criteria. Disagree-
ments about inclusioncriteria were resolved by consensus and con-
sultation with a third author (BGOS).
Assessment of methodological quality
The assessment of methodological quality took intoaccount secure
methodof randomisation, allocationconcealment, observer blind-
ing, patient blinding, differences at baseline of the experimental
groups, and completeness of follow-up. These items were assessed
according to the Cochrane Collaboration standard scheme: grade
A: adequate, grade B: unclear, grade C: inadequate or not done.
Two authors (LJT, VPV) assessed quality independently. Disagree-
ment between the authors was resolved by discussion if necessary
with a third author (BGOS).
Data extraction
Two authors independently extracted data on participants, meth-
ods, interventions, outcomes and results using a specially con-
structed data extraction form. Missing data were obtained from
the trial authors whenever possible.
Analysis of data
Data were entered and analysed using Review Manager 5.0.5
(RevMan) software. For dichotomous data, relative risks (RR) with
95% condence intervals (CI) were estimated based on the xed-
effect model or on the random effects model if heterogeneity was
present. The number needed to treat (NNT) and number needed
to harm (NNH) were calculated if possible. For continuous out-
comes, weighted mean differences (WMD) between groups were
estimated.
Heterogeneity was assessed by the chi-squared test and was as-
sumed to be present when the signicance level was lower than
0.10 (p < 0.10). When signicant heterogeneity was present, an
attempt was made to explain the differences based on clinical char-
acteristics of the included studies. A sensitivity analysis was per-
formed, omitting trials which included participants with different
clinical characteristics or trials with lower methodological quality.
If there had been sufcient trials of the same intervention, we
would have constructed a funnel plot (of trial effect versus trial
size) to assess potential publication bias.
Subgroup analysis
Separate subgroup analyses of participants with more severe dis-
ability (House Grade III or worse) and less severe disability (House
Grade II or better) were undertaken. We also considered patients
treated before and after two weeks from onset.
R E S U L T S
Description of studies
See: Characteristics of includedstudies; Characteristics of excluded
studies; Characteristics of studies awaiting classication.
The literature search and hand searching identied 41 potentially
relevant articles (Cochrane databases = 7, MEDLINE = 17, EM-
BASE = 23, CINAHL = 6, LILACS = 3; PEDro = 11 and hand-
searching = 2), (see Figure 1). Some studies were found in more
than one database. Of these, six trials met the inclusion criteria (
Beurskens 2003; Flores 1998; Manikandan 2007; Mosforth 1958;
Wang 2004; Wen 2004). Eight other studies, all in Chinese, await
translation and assessment.
Excluded studies
Twenty seven studies were excluded because they were:
1. Series of cases or case reports (Aleev 1973; Brach 1999;
Brown 1978; Coulson 2006b; Danile 1982; Lobzin 1989;
Manca 1997; Romero 1982; Segal 1995a).
2. Retrospective studies (Bernardes 2004; Cronin 2003; Dalla-
Toffola 2005).
3. Non-systematic reviews (Goulart 2002; Beurskens 2004).
4. Not physical therapy interventions (Casler 1990; Klingler
1982; Taverner 1966; Zhao 2005).
5. Constrained by methodological restrictions (Dubravica
1996; Koyama 2005; Murakami 1993; Nakamura 2003; Shiau
1995).
6. Composed of few participants with idiopathic facial palsy (
Balliet 1982; Coulson 2006; Ross 1991; Segal 1995b).Details
can be found in the Characteristics of excluded studies.
Included studies
The six studies (Beurskens 2003; Flores 1998; Manikandan 2007;
Mosforth 1958; Wang 2004; Wen 2004) (See Characteristics
of included studies) included a total of 547 people. Three tri-
als studied manual therapy and electrostimulation (Flores 1998;
Manikandan 2007; Mosforth 1958) (294 participants), and three
involved exercise (Beurskens 2003; Wen 2004; Wang 2004) (253
participants).
The rst study evaluating physical therapy for facial palsy was one
of the rst physical therapy randomised controlled trials described
for any condition. Mosforth (Mosforth 1958) studied 86 people
with acute Bells palsy of less than 14 days duration. Three partic-
ipants were lost to follow up. Auto-massage of the face, infrared
and interrupted galvanic stimulation (pulse 100 msec) in 44 par-
ticipants, was compared to massage alone in42 participants. Treat-
ment was continued until recovery or until the condition seemed
stationary (two to six months). The outcomes were electrical ex-
amination and grade of paralysis estimated visually as a percentage
of the function of the normal side, the time to begin improvement
and the time to complete recovery.
Manikandan 2007 assessedthe results of 59participants withacute
facial palsy and compared two groups with physiotherapy inter-
ventions. Although the objective of the study was to test a specic
exercise strategy and both groups undertook different exercises,
the regimen adopted was similar (home based exercises) and elec-
trotherapy was the maindifference betweenthe groups. One group
of 30 people underwent a xed protocol with electrostimulation
(galvanic and faradic currents) for the two rst weeks, massage and
gross facial exercises. The other 29 people learnt an individualized
exercise program focused on the quality of the exercises and not
on the quantity. The movements were to be symmetrical without
voluntary movement of the uninvolved side. All individuals were
assessed by the Facial Grading Scale (Roos 1996) at the outset and
after three months.
In Flores 1998, there were 149 participants with acute Bells
palsy (onset in one to three days). Twenty-nine people (19.46%)
dropped out without a description of the reason for drop out.
One group of 76 people were treated with infrared treatment and
electrostimulation and were compared to 72 people treated with
prednisone for up to 14 days. Outcomes were time to recover, clin-
ical history and a functional scale (May Scale). Authors analysed
different groups according to whether the lesion was thought to
be proximal or distal to the origin of the chorda tympani nerve.
The Flores 1998 study was analysed with caution. Because corti-
costeroids have now been shown to be efcacious (Sullivan 2007),
comparing physical therapies with this active treatment could be
considered inappropriate. Nevertheless we included this study and
discussed some outcomes .
Beurskens 2003 studied 50 people with chronic (more than nine
months) facial paralysis. Only 34people hadidiopathic facial palsy.
Sixteen received exercises (mime therapy) and the other 18 formed
a waiting list control group. Mime therapy consists mainly of facial
mimic exercises. Outcomes were face stiffness, lip mobility, the
Facial Disability Index (VanSwearingen 1996), the Sunnybrook
Facial Grading Scale (Roos 1996), and the House-Brackmann Fa-
cial Grading System (House 1985). The author kindly sent us
all the outcomes for the idiopathic facial palsy participants. The
mean baseline House-Brackmann score was 4 and after one year it
was 3 for all the treatment participants. Although all participants
apparently improved, in the protocol for this review we made the
assumption that a grade over 3 could mean improvement but does
not mean recovery. It was based on a previous study (Peitersen
2002) andthe clinical meaning of House-Brackmangrades (House
1985). The continuous data results were more signicant. How-
ever, the samples were composed of 16 and 18 individuals with
Bells palsy in the exercise and control groups respectively. This
small sample is a signicant limitation. More observations on this
study are made in the Discussion.
Wen2004 studied 145 people with acute idiopathic facial palsy for
12 weeks. Eighty-ve participants were submitted to a combina-
tion of conventional therapy plus facial rehabilitation exercises
(movements using facial muscles) while 60 participants received
only conventional therapy not detailed in the translation pro-
cess. This Chinese study presented the following outcomes anal-
ysed in the review: (1) time when the patient started to recover
and (2) time that the recovery was complete. The study analysed
groups of mild, moderate and severe dysfunction patients.
Wang 2004 treated 74 people with acute Bells palsy with two dif-
ferent strategies. Both groups received medicine (cortisone, and
mexobalamin and vitamin B2), physical treatment (not described
in the translation), massage, and acupuncture. For the exercise
therapy (n = 43), functional exercises were added. The outcome
was facial muscle function with the Potmann Score after one
month.
Risk of bias in included studies
The scores of methodological quality for each trial can be found
in Table 1.
Table 1. Methodological Quality Assessment
Study ID Secure method random Allocation Blinding Follow-up
Mosforth 1958 A A Not done A
Flores 1998 B B Not done B
Wen 2004 B B Not done C
Wang 2004 A A Assessor blind A
Beurskens 2006 C C Assessor blind A
Manikandan 2007 A A Not done A
Secure method of randomisation and allocation
concealment
Mosforth 1958 randomised the groups using a prepared list (grade
A). Beurskens (Beurskens 2003) used a coin ip to assign the
rst participant and the others were allocated by alternation and
this was classied as inadequate allocation concealment (grade
C). Manikandan 2007 used a method of six blocks with 10 in
each block (grade A) and Wang 2004 randomised their samples
by computer (grade A). Two studies (Flores 1998; Wen 2004)
classied their trial as randomised, but they did not describe the
method of randomisation (grade B).
Blinding
Due to the nature of the intervention evaluated in this review,
effective blinding of the participants is problematic. Placebo elec-
trostimulation could have been used but blinding to exercise in-
terventions is impractical or impossible. Blinding of outcome as-
sessors can be achieved but only Beurskens 2003 and Wang 2004
blinded the assessor.
Differences in baseline between groups
Wen 2004 did not present the baseline characteristics of the par-
ticipants. Manikandan 2007, Mosforth 1958, Flores 1998, and
Wang 2004 reported number, sex, age and duration of the palsy
indicating no signicant differences between groups. Beurskens
2003 reported no signicant differences between groups at base-
line for demographic data and severity and duration of facial palsy.
Completeness of follow-up
Beurskens 2003 and Mosforth 1958 assessed outcomes at one year
follow up. Beurskens analysed all the 50 participants (of whom
34 had Bells palsy) at this time. Mosforth did not analyse all the
people after one year because they were discharged when recov-
ered. Despite this, our analyses were not affected. The data of in-
terest (incomplete recovery) were reported by the study and drop
outs were considered to have incomplete recovery in our intention
to treat analysis. Flores 1998 did not describe follow up and 29
people (19.26%) dropped out without description of their alloca-
tion groups. The reasons described were that the participants re-
quested another medication or they had not adhered to the treat-
ment. Manikandan 2007 and Wen 2004 followed subjects until
12 weeks and Wang 2004 until 30 days, the end of the treatment
period.
Effects of interventions
The results have been divided by the intervention and described
according to the results for each of our outcome measures.
ELECTRICAL STIMULATION
Primary outcome measure
Mosforth 1958 studied the efcacy of electrotherapy after six
months in a total of 86 participants (n = 44 electrical stimulation
and n = 42 control). The graphs were constructed using an inten-
tion-to-treat analysis and less than 75% recovery was considered
a bad outcome. The relative rate of improvement was not signi-
cantly different, relative risk (RR) 1.30, 95% CI 0.68 to 2.5 (see
Analysis 1.1).
Manikandan 2007 described results after three months on a con-
tinuous scale. The Facial Grade Score measured rest score, synk-
inesis scores and movement score of the 28 participants in each
group. The rst two scores did not show statistical signicance.
The movement score improved signicantly in the group with-
out electrical stimulation, mean difference (MD) 68.00, 95% CI
59.93 to 76.07 (see Analysis 1.2). Consequently the total score
improved, MD 12.00, 95% CI 1.26 to 22.74 (see Analysis 1.2).
In Flores 1998 study ten (12.98%) of the 77 participants that were
treated with electrical stimulation, and 11 (15.27%) of the 72
treated with prednisone had incomplete recovery after 6 months,
RR 0.85, 95% CI 0.38 to 1.88 (see Analysis 2.1).
Secondary outcome measures
(1) Presence of motor synkinesis, contracture, hyperkinesia,
facial spasm or crocodile tears six months after onset
Mosforth 1958 showed no signicant differences between the
group receiving electrical stimulation and the control group in re-
spect of facial muscle contracture. Eleven participants (25%) in
the treated group and eight (20%) in the control had contracture,
RR 1.25, 95% CI 0.56 to 2.79.
Manikandan 2007 reported 2 participants in the group receiving
exercise and electrical stimulation that presented with mild synk-
inesis after three months, and none in the group with exercise
alone. This was considered non signicant, RR0.20, 95%CI 0.01
to 3.99.
(2) Incomplete recovery after one year
Mosforth 1958 reported no statistically signicant differences in
this assessment, RR 1.15, 95% CI 0.55 to 2.36 (see Analysis 1.1).
(3) Adverse effects attributable to the intervention such as
pain or worsening of condition
No adverse effects were attributed to the interventions.
Subgroup analyses
Flores 1998 undertook a subgroup analysis by severity of the ax-
onal damage. In the group with mild disease or with lesions distal
to the chorda tympani lesion (n = 102) all individuals in both
groups improved at six months. In the most severe group or le-
sions proximal to the chorda tympani (n = 47) there was no signif-
icant difference in recovery, RR = 0.62, 95% CI 0.34 to 1.15 (see
Analysis 2.2). Analysing mean time to recovery of the 149 partic-
ipants in the study in days, we found signicantly faster recovery
with electrical stimulation, (MD -8.38, 95% CI -13.99 to -2.77
Analysis 2.3). However Manikandan 2007 gave opposite results.
FACIAL EXERCISES
Primary outcome measure
Beurskens 2003 included only 34 participants with chronic (more
than nine months) Bells palsy. All participants in the exercise
group improved but none in the control group improved.
Wen 2004 compared facial exercises (n = 85) with medication (n =
60). There was no signicant difference in improvement between
the groups at three months. 92.94% of participants in the exercise
group and 88.33% of participants in the control group recovered,
RR 0.61 95% CI 0.21 to 1.71 (see Analysis 4.1).
Wang 2004 compared a combination of medicines, acupuncture
and physiotherapy (n = 31) with the same interventions plus func-
tional exercises (n = 43). The single outcome was facial muscle
function (Potmann Score) after one month. It showed a statis-
tically signicant difference in favour of the functional exercise
group, MD 8.47, 95% CI 7.05 to 9.89. .
Secondary outcome measures
(1) Presence of motor synkinesis, contracture, hyperkinesia,
facial spasm or crocodile tears six months after onset
Wen 2004 reported signicantly less facial motor synkinesis after
exercise, with 12 cases in the control group (20%) and 4 cases in
the exercise group (4.7%), RR = 0.24, 95% CI 0.08 to 0.69.
(2) Incomplete recovery after one year
According to the criteria for this review, none of the participants
recovered completely after one year. Beurskens 2003 kindly sent
us the continuous outcomes after one year. These all showed im-
provements in favour of the exercise group: Facial Grading Scale
WMD20.40, 95%CI 8.74 to 32.04; Facial Disability Index Phys-
ical MD 10.30, 95% CI -1.37 to 21.97, and the Facial Disability
Index Social MD 14.50, 95% CI 4.85 to 24.15 (see Analysis 3.1,
Analysis 3.2 ), in favour of exercise.
(3) Adverse effects attributable to the intervention such as
pain or worsening of condition
No adverse effects were attributable to the interventions
Subgroup analyses
Wen 2004 presented data on participants with mild and more se-
vere disease. There was no difference in the proportion of partici-
pants that improved in the exercise group and conventional ther-
apy group in the individuals with mild paralysis (Analysis 4.2).
But when we analysed the sub-group with moderate severity, we
observed that the exercise group began (Analysis 4.2) and nished
(Analysis 4.3) improving sooner.
D I S C U S S I O N
In the light of the numerous physical therapies used for treating
Bells palsy in daily practice, this review highlights the lack of high
quality evidence to support the use of these strategies. Electrother-
apy, exercises, biofeedback, manual therapy and laser were evalu-
ated in some studies, but only trials involving electrostimulation
and exercise had the minimum methodological quality to be con-
sidered for this systematic review.
Electrical stimulation
Almost all the outcomes reported failed to show any statistically
signicant difference between either electrotherapy or exercises
and conventional or no treatment. Mosforth 1958 concluded that
it is not possible to recommend electrostimulation and questions
its cost-effectiveness. The results of Manikandan 2007 are inagree-
ment as the group with electrical stimulation had worse quality
of movement and functional recovery after three months. Flores
1998 found no differences in the proportion of participants with
recovery after six months. The time to recovery in the Flores study
was less in the electrostimulation group but the study had some
methodological restrictions such as comparing physiotherapy with
prednisone, an active treatment, and almost 20% participant drop
outs. No statistical differences were found in synkineses or other
complications in any of the trials.
Exercise
Neither Wen2004 studying acute cases nor Beurskens 2003 study-
ing chronic cases found differences in the proportion recovering
after three and six months. Signicantly less synkinesis was ob-
served by Wen 2004 after three months. The evidence was limited
by the restrictions of reported outcomes to continuous data. The
assessment was blinded in two studies (Beurskens 2003; Wang
2004).
Comments about the methodology
Almost all the included studies had some limitations to be con-
sidered in future research.
In the electrical stimulation trials Flores 1998 compared electros-
timulation and prednisolone, an active treatment, which could
have biased the study results. Manikandan 2007 used different
exercise regimens in both groups but the main difference was the
use of electrical stimulation in one of the groups. This modied
the way data have been analysed and we considered that the study
testedelectrical stimulationrather thandifferent exercise regimens.
In the exercise trials, Beurskens 2003 studied chronic facial palsy
and included participants with dysfunctions other than idiopathic
facial palsy, which reduced the size of the sample of interest for this
review and limited conclusions. Wang 2004 and Wen 2004 com-
pared combinations of physiotherapy and medicine with func-
tional exercises which complicated interpretation.
The main outcomes used were continuous scales of motor func-
tion. In another publication Beurskens 2004b discussed the out-
comes of applying exercise to treat facial paresis. He observed a
signicant recovery in the outcomes in participants receiving ex-
ercise for palsies lasting more than nine months: asymmetry in the
face at rest, asymmetry during voluntary facial movements, synk-
ineses, complaints concerning pain, stiffness, involuntary move-
ments, reports concerning difculties in eating, drinking, speak-
ing, and patient perception about their quality of life. Although
the House-Brackmann score was used as an overall measure of fa-
cial impairment, the authors stated that it was not sensitive enough
to measure improvement during therapy with exercise in chronic
cases. The Facial Grading Scale (Roos 1996) and the Facial Dis-
ability Index (VanSwearingen 1996) were considered good assess-
ment options.
We would have preferred to convert continuous data into dichoto-
mous data. For example, for recent Bells palsy we expect a mini-
mumof 71%recovery (House-Brackmann scores of I or II) before
three months. In chronic stationary cases with House-Brackman
scores of III or IV, patients might nd lesser degrees of improve-
ment valuable.
In subgroups with severe dysfunction, complications or seque-
lae were the clinical outcomes considered. Peitersen 2002 re-
ported that out of more than 2500 people with facial paralysis,
29% had persistent weakness, 17% contracture and 16% synkine-
sis. Wen 2004 described twelve cases out of 85 participants with
synkinesis in the control group (14%) and four out of 60 cases
in the exercise group (6.6%). More studies are needed to conrm
this.
However, the trials in which improvements were reported as con-
tinuous outcomes are less reliable, particularly if they were not
blinded. It is not impossible to blind such studies, since the authors
can either introduce an observer who had not seen the patient
before or take photographs or even videos, as in the Beurskens
2003 and Wang 2004 studies. Nevertheless these studies had other
limitations.
Other clinical references used in the studies were the times to
onset of recovery and times to complete recovery. Some dif-
ferences emerged between the groups treated with physical ther-
apy and other treatment (prednisone or other medication). The
time to improvement seemed to be shorter in participants receiv-
ing physical therapies, even in mild, as well as moderate grades of
paralysis but these results are really not reliable.
The conclusions of this systematic review were limited by the low
number and poor quality of studies and the heterogeneity of the
results .
A U T H O R S C O N C L U S I O N S
Implications for practice
There is no evidence of signicant benet or harmfromthe limited
trials of electrical stimulation or facial exercises for Bells palsy.
Implications for research
There is a need for well-designed, randomised trials of electrical
stimulation, exercise and other physical therapies for Bells palsy.
Reports of such trials should give details of the treatments given
including dose and duration. Outcome measures should be se-
lected which are likely to be adequately responsive for detecting
change with physical therapies. Measures should include facial ap-
pearance, function (eating and drinking and speaking), facial ap-
pearance (including asymmetry and involuntary movements), and
quality of life. Recovery at dened times such as three, six and
twelve months of treatment is easier to measure accurately than
the time to recovery. Use of photography or video to blind the
outcome assessor is encouraged.
A C K N O W L E D G E M E N T S
The staff of the Brazilian Cochrane Centre, Cochrane Neuro-
muscular Desease Group, Dr David Allen for his important con-
tribution reviewing the protocol and a special thanks to Pro-
fessor Richard Hughes for all the comments during all the ed-
itorial process. Rachel Barton for the search strategy and the
database searches. To Dr Zhannat Idrissova, Dr Hitoshi Nukada
and Yuquian Ma for the translations. Kate Jewitt, Janice Fernandes
and Jane Batchelor for all the support. Special thanks to my wife,
Cinira Gomes, and our daughter Rafaela for the patience and love
all the time.
R E F E R E N C E S
References to studies included in this review
Beurskens 2003 {published and unpublished data}
Beurskens CHG, Heymans PG. Mime therapy improves facial
symmetry in people with long-term facial nerve paresis: a
randomized controlled trial. Australian Journal of Physiotherapy
2006;52(3):17783.
Beurskens CHG, Heymans PG. Positive effects of mime therapy

on sequelae of facial paralysis: stiffness, lip mobility, and social and
physical aspects of facial disability. Otology & Neurotology 2003;24
(4):67781.
Beurskens CHG, Heymans PG, Oostendorp RAB. Stability of
benets of mime therapy in sequelae of facial nerve paresis during a
1-year period. Otology & Neurotology 2006;27(7):103742.
Flores 1998 {published data only}
Flores PF, Medina RZ, Haro LG. Idiopathic peripheral facial
paralysis treatment physic therapy versus prednisone [Tratamiento
de la parlisis facial perifrica idioptica: terapia fsica versus
prednisona]. Revista mdica del Instituto Mexicano del Seguro Social
1998;36(3):21721.
Manikandan 2007 {published and unpublished data}
Manikandan N. Effect of facial neuromuscular re-education on
facial symmetry in patients with Bells palsy: a randomized
controlled trial. Clinical Rehabilitation 2007;21(4):33843.
Mosforth 1958 {published data only}
Mosforth J, Taverner D. Physiotherapy for Bells palsy. British
Medical Journal 1958;2(5097):6757.
Wang 2004 {unpublished data only}
Wang XH, Zhang LM, Han M, Zhang KQ. Clinical application of
functional exercise and staged therapy in treatment of facial nerve
paralysis. Zhonghua Linchuang Kangfu Zazhi [Chinese Journal of
Experimental and Clinical Virology] 2004;8(4):6167.
Wen 2004 {unpublished data only}
Wen CM, Zhang BC. Effect of rehabilitation training at different
degree in the treatment of idiopathic facial palsy: a randomized
controlled comparison. Zhongguo Linchuang Kangfu 2004;8(13):
24467.
References to studies excluded from this review
Aleev 1973 {unpublished data only}
Aleev LS. Experience in the treatment of facial nerve neuritis using
the method of programmed multi-channel bioelectrical control.
Zhurnal Nevropatologii i Psikhiatrii Imeni S. S. Korsakova 1973;73
(3):34550.
Balliet 1982 {published data only}
Balliet R, Shinn JB, Bach-y-Rita P. Facial paralysis rehabilitation:
retraining selective muscle control. International Rehabilitation
Medicine 1982;4(2):6774.
Bernardes 2004 {published data only}
Bernardes DFF, Gomez MVSG, Pirana S, Bento RF. Functional
prole in patients with facial paralysis treated in a myofunctional
approach. Pr-fono 2004;16(2):1518.
Beurskens 2004c {published data only}
Beurskens CHG, Devriese PP, van Heiningen I, Oostendorp RAB.
The use of mime therapy as a rehabilitation method for patients
with facial nerve paresis. International Journal of Therapy and
Rehabilitation 2004;11(5):20610.
Brach 1999 {published data only}
Brach JS, VanSwearingen JM. Physical therapy for facial paralysis: a
tailored treatment approach. Physical Therapy 1999;79(4):
397404.
Brown 1978 {published data only}
Brown DM, Nahai F, Wolf S, Basmajian JV. Electromyographic
biofeedback in the reeducation of facial palsy. American Journal of
Physical Medicine 1978;57(4):18390.
Casler 1990 {published data only}
Casler JD, Conley J. Simultaneous dual system rehabilitation in
the treatment of facial paralysis. Archives of Otolaryngology Head
and Neck Surgery 1990;116(12):1399403.
Coulson 2006 {published data only}
Coulson SE, Adams RD, ODwyer NJ, Croxson GR. Physiotherapy
rehabilitation of the smile after long-term facial nerve palsy using
video self-modeling and implementation intentions. Otolaryngology
- Head and Neck Surgery 2006;134(1):4855.
Coulson 2006b {published data only}
Coulson SE, Adams RD, ODwyer NJ, Croxson GR. Use of video
self-modelling and implementation intentions following facial
nerve paralysis. International Journal of Therapy and Rehabilitation
2006;13(1):305.
Cronin 2003 {published data only}
Cronin GW, Steenerson RL. The effectiveness of neuromuscular
facial retraining combined with electromyography in facial paralysis
rehabilitation. Otolaryngology - Head and Neck Surgery 2003;128
(4):5348.
Dalla-Toffola 2005 {published and unpublished data}
Dalla-Toffola E, Bossi D, Buonocore M, Montomoli C, Petrucci L,
Alfonsi E. Usefulness of BFB/EMG in facial palsy rehabilitation.
Disability and Rehabilitation 2005;27(14):80915.
Danile 1982 {published data only}
Danile V, Marongiu A, Candioto G. New therapeutic method by
ionophoresis of a drug cocktail in facial paralysis a frigore [Nuovo
metodo terapeutico ionoforetico con cocktail medicamentoso della
paresi facciale a frigore]. Policlinico - Sezione Medica 1982;89(2):
1606.
Dubravica 1996 {published data only}
Dubravica M, Musura M, Nesek-Madaric V, Stajner-Katusic S,
Horga D. Treatment of facial palsy by EMG biofeedback technique
- Muscle relaxation technique. Acta Clinica Croatica 1996;35(1-2):
1720.
Goulart 2002 {published data only}
Goulart F, Vasconcelos KSS, Souza MRV, Pontes PB. Physical
therapy for facial paralysis using the biofeedback [A utilizao do
biofeedback no tratamento da paralisia facial perifrica]. Acta
Fisitrica 2002;9(3):13440.
Klingler 1982 {published data only}
Klingler D, Bibl D. Peripheral facial paralysis-role of early onset of
therapy. Wiener Medizinische Wochenschrift 1982;132:14953.
Koyama 2005 {unpublished data only}
Koyama S, Okada K, Yamakawa T, Kubo M, Amatsu H. The
usefulness of manipulative physiotherapy in treating bells palsy.
Medical Journal of Minami Osaka Hospital 2005;53(1):557.
Lobzin 1989 {unpublished data only}
Lobzin VS, Smetankin AA, Tsatskina ND, Iashin NS. Treatment

of Bells palsy by using portable biofeedback devices. Zhurnal
Nevropatologii i Psikhiatrii Imeni S. S. Korsakova 1989;89(10):
5762.
Lobzin VS, Tsatskina ND. The adaptive biological control system
with electromyographic feedback in the treatment of Bells palsy
[Russian]. Zhurnal Nevropatologii i Psikhiatrii Imeni S. S. Korsakova
1989;89(5):547.
Manca 1997 {published data only}
Manca M, Contenti E, Mura G, Basaglia N, Cavazzini L. EMG
biofeedback in peripheral facial nerve palsy rehabilitation. Europa
Medicophysica 1997;33(3):1437.
Murakami 1993 {published data only}
Murakami F, Kemmotsu O, Kawano Y, Matsumura C, Kaseno S,
Imai M. Diode low reactive level laser therapy and stellate ganglion
block compared in the treatment of facial palsy. Laser Therapy
1993;5(3):1315.
Nakamura 2003 {published data only}
Nakamura K, Toda N, Sakamaki K, Kashima K, Takeda N.
Biofeedback rehabilitation for prevention of synkinesis after facial
palsy. Otolaryngology - Head and Neck Surgery 2003;128(4):53943.
Romero 1982 {published data only}
Corral-Romero MA, Bustamante-Balcarcel A. Biofeedback
rehabilitation in seventh nerve paralysis. The Annals of Otology,
Rhinology, and Laryngology 1982;92(2 Pt 1):1668.
Ross 1991 {published data only}
Ross B, Nedzelski J, Mclean J. Efcacy of feedback training in long-
standing facial paresis. Laryngoscope 1991;101(7 Pt 1):74450.
Segal 1995a {published data only}
Segal B, Hunter T, Danys I, Freedman C, Black M. Minimizing
synkinesis during rehabilitation of the paralyzed face: Preliminary
assessment of a new small-movement therapy. Journal of
Otolaryngology 1995;24(3):14953.
Segal 1995b {published data only}
Segal B, Zompa L, Danys I, Black M, Shapiro M, Melmed C, et
al.Symmetry and synkinesis during rehabilitation of unilateral facial
paralysis. Journal of Otolaryngology 1995;24(3):1438.
Shiau 1995 {published data only}
Shiau J, Segal B, Danys I, Freedman R, Scott S. Long-term effects
of neuromuscular rehabilitation of chronic facial paralysis. The
Journal of Otolaryngology 1995;24(4):21720.
Taverner 1966 {published data only}
Taverner D, Fearnley ME, Kemble F, Miles DW, Peiris OA.
Prevention of denervation in Bells palsy. British Medical Journal
1966;5484:3913.
Zhao 2005 {published data only}
Zhao Y, He L, Zhang QH. Effectiveness of three different
treatments for peripheral facial paralysis. Chinese Journal of Clinical
Rehabilitation 2005;9(29):413.
References to studies awaiting assessment
Diao 2002 {published data only}
Diao L, et al.Comparison of the efcacy between acupuncture and
manipulation for Bells palsy. Journal of Huaihua Medical College
2002;1(2):345.
Guo 2006 {published data only}
Guo QH, Yan JZ, Yan WS, Xiao MZ. Observation on non-invasive
electrode pulse electric stimulation for treatment of Bells palsy.
Zhongguo Zhenjiu 2006;26(12):8578.
Li 2005 {published data only}
Li J. Comparison the efcacy between acupuncture and
manipulation for Bells palsy. Chinese Clinical Medicine Research
2005;11(12):17156.
Pan 2004 {published data only}
Pan L. Acupuncture plus short wave for 38 peripheral facial
paralysis. Journal of Clinical Acupuncture & Moxibustion 2004;20
(4):267.
Qu 2005 {published data only}
Qu Y. Clinical observation on acupuncture by stages combined with
exercise therapy for treatment of Bell palsy at acute stage. Zhongguo
zhen jiu [Chinese Acupuncture & Moxibustion] 2005;25(8):5457.
Wang 2004b {published data only}
Wang XH, Zhang LM, Han M, Zhang KQ, Jiang JJ. Treatment of
Bells palsy with combination of traditional Chinese medicine and
western medicine. Hua xi kou qiang yi xue za zhi [West China
Journal of Stomatology Stomatology] 2004;22(3):2113.
Yang 2001 {published data only}
Yang G. Comparison of the efcacy between acupuncture and
therapy apparatus for Bells palsy. Journal of Clinical Acupuncture &
Moxibustion 2001;17(8):289.
Zhang 2005 {published data only}
Zhang H. Acupuncture combined with facial muscle training for
peripheral facial paralysis. Chinese Journal of Rehabilitation Theory
and Practice 2005;11(12):10378.
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Adour KK. Current concepts in neurology: diagnosis and
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Adour 2002
Adour KK. Decompression for Bells palsy: why I dont do it.
European Archives of Otorhinolaryngology 2002;259(1):407.
Allen 2004
Allen D, Dunn L. Aciclovir or valaciclovir for Bells palsy
(idiopathic facial paralysis). Cochrane Database of Systematic Reviews
2004, Issue 3.
Beurskens 2004
Beurskens CHG, Burgers-Bots IAL, Kroon DW, OOstendorp
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Beurskens 2004b
Beurskens CHG, Heymans PG. Physiotherapy in patients with
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Gilden 2004
Gilden DH. Clinical Practice. Bells palsy. The New England
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Indicates the major publication for the study

C H A R A C T E R I S T I C S O F S T U D I E S
Characteristics of included studies [ordered by study ID]
Beurskens 2003
Methods Blinding: the assessors of outcomes were unaware of the allocation.
Analysis: differences (between the experimental and control group and between pre- and post-tests). Data
were collected concerning the level of impairment, disability, and handicap of the patient in pre-test and
post-test measures in both the treatment and the control groups.
Duration: 3 months of therapy.
Follow up: 3 measurement occasions within 1 year: immediately, 3 and 12 months after therapy.
Center: Radboud University NijmegenMedical Center, Nijmegen, The Netherlands and Vrije Universiteit
Medical Center, Amsterdam.
Design: Randomised clinical trial.
Participants N = 50 peripheral facial nerve paresis (34 idiopathic). 2 dropped out in each group.
Diagnosis: people with sequelae of facial paralysis, House-Brackmannn IV, for at least 9 months; no nerve
or muscle reconstruction; absence of complete, partial, or central facial paralysis; absence of congenital
facial paralysis; and sufcient knowledge of the Dutch language.
Gender: both sexes (21 males and 29 females), including the participants with other causes of facial palsy.
Race: not mentioned.
Age: median 44 years (20 to 73, SD 14) including the participants with other causes of facial palsy.
Setting: Physiotherapy outpatient department
Interventions 1. Exercises (mime therapy) on a individual basis in sessions of 45 minutes, once weekly, over 3
months (10 sessions) and home program of exercises. N = 16
2. Control group (waiting list). N =18
Outcomes Stiffness of the face. Lip mobility (both lip and pout length).
Physical and social index of the Facial Disability Index (VanSwearingen 1996 )
Sunnybrook Facial Grading System.
House-Brackmann Facial Grading System.
Notes This study description is the pool of three publications by the author about the same population and
groups.
Risk of bias
Item Authors judgement Description
Allocation concealment? No C= Inadequate. A coin ip for the rst participant
and then pairs of patients as they became available
Flores 1998
Methods Blinding: not done.
Analysis: The participants were divided, for purposes of analysis, into those with and those without
electromyographic evidence of denervation.
Duration: Until functional recovery was achieved according to the May Scale, with evaluations every 14
days.
Follow up: not described.
Center: Medicina Fsica y Rehabilitacion Department, Hospital General Regional Num 1, Culiacn,
Sinaloa, Mxico.
Participants N = 149
Diagnosis: acute Bells palsy of onset within 1 to 3 days. EMG 8 days after onset. Excluded other causes
of facial paralysis.
Gender: both sexes (males 61 and females 88)
Race: not mentioned
Age: median 33 (3 to 60) years.
Setting: clinic.
History/Comorbidities: normal glycemia and arterial pressure.
Interventions 1. Prednisone (1mg/Kg /day) up 14 days. N = 72.
2. Infrared treatment for 20 min and faradic stimulation (10 to 15 stimulation/min in motor points
not described). N = 76
Outcomes Clinical history and May Scale (grade I - complete recovery, II - complete recovery with facial asymmetry
with movements between 2 to 6 months, and III - incomplete recovery with asymmetry, synkinesis for
more than 6 months).
Drop out: 29 people (19.26%) without describing the exact reason for drop out or the groups they were
allocated to. Reasons: participants requested another medication or they did not adhere to the treatment.
Notes We are waiting for the authors answer about details of the study.
Risk of bias
Allocation concealment? Unclear B - Unclear. Allocation not described
Manikandan 2007
Methods Blinding: no.
Analysis: the authors used Wilcoxon signed-rank test and Mann Whitney U-test to compare the Facial
Grading Scale scores within each group.
Duration: three months of therapy.
Follow up: three months. Until the end of the therapy.
Center: Kasturba Hospital, Manipal, Karnataka, India.
Manikandan 2007 (Continued)
Participants N = 59 participants.
Diagnosis: unilateral Bells palsy with a mean duration of two weeks.
Excluded people with diseases of the central nervous system, sensory loss over the face, recurrence of facial
paralysis and who were uncooperative during the study.
Gender: both sexes (males 24 and females 37).
Age: median of 35 years old.
Setting: Neurorehabilitation unit.
History/Comorbidities: non described
Interventions 1. Exercises (facial neuromuscular reeducation)on a individual basis taught to patients, 5 to 10
repetitions, 3 x /day, for 3 months. N = 29.
2. Fixed protocol of electrical stimulation (3 x/day, for six days in 2 weeks. 90 contractions with
galvanic current in each muscle plus 10 contractions with faradic current in each facial nerve trunk,
intensity until minimal visible contraction)Gross facial expression exercises taught to patients for 3
months. N = 30
Participants in both the groups were instructed to use a hand-held mirror during the exercise. Facial
massage was given and strapping was applied to the face to maintain the symmetry.
Outcomes Facial Grading Scale (facial symmetry at: rest, movement and synkinesis)before and after 3 months.
Notes Two patients in group 2 developed mild synkinesis post treatment.
One patient from group 1 and two from group 2 dropped out before the completion of the study with
reasons stated.
Risk of bias
Allocation concealment? Yes A - Adequate. Randomisation using six blocks with
10 in each block.
Mosforth 1958
Methods Blinding: none.
Analysis: The participants were divided, for purposes of analysis, into those with and those without
electromyographic evidence of denervation.
Duration: the treatment was given daily until the active contractions returned and then thrice weekly
until recovery was virtually complete or the condition seemed stationary (2 to 6 months).
Follow up: one year.
Center: Department of Electromyography Leeds General Inrmary.
Design: controlled randomised trial.
Participants N = 86 people with Bells palsy.
Diagnosis: clinically excluding other causes. Complete or partial paralysis of one side of the face, sudden
onset.
Duration: less than 14 days (mean 5.2).
Gender: both sexes males 40 and females 43.
Mosforth 1958 (Continued)
Age: 37.5 years old (3 to 79 years).
Setting: clinic.
History/Comorbidities: the groups were comparable at baseline.
Interventions 1. Auto-massage of the face plus infrared for 10 min plus interrupted galvanic stimulation of 11
muscles of the face for 3 times of 30 contraction (pulse 100 msec). N = 44
2. Massage. N = 42
Outcomes Electrical examination.
Grade of paralysis estimated visually as a percentage of the function of the normal side.
Notes One patient from group 1 and two from group 2 dropped out before the completion of the study with
reasons.
Risk of bias
Allocation concealment? Yes A - Adequate. A prepared list.
Wang 2004
Methods Blinding: no.
Analysis: Improvement Index =(Scores After Treatment - Scores Before Treatment)/Scores After Treatment
Duration: one month (30 days).
Follow up: one month. Until the end of the therapy.
Center: Neurology Department of West China Hospital.
Design: randomised clinical trial.
Participants N = 74 people with Bells palsy.
Diagnosis: diagnosedas facial nerve paralysis by Neurology Department of West China Hospital. Exclusion
caused central, traumatic or auditory facial nerve paralysis.
Duration: lasting for less than 1 month.
Gender: both sexes males 1 and females 0.79 (therapy) and males 1 and females 0.41 (control).
Race: Chinese.
Age: therapy group mean 1 - 41.56 (SD14.47) years old, and control group - 40.87 (13.46) years.
Setting: hospital.
History/Comorbidities: not mentioned.
Interventions 1. Drug plus physical treatment plus massage plus acupuncture plus functional exercise. N = 43.
1-7 days - drug treatment and physical treatment.
8-14 days - drug treatment, physical treatment, functional exercise and massage and acupuncture
treatment.
14-30 days - physical treatment, functional exercise and massage and acupuncture treatment.
2. Drug plus physical treatment plus massage plus acupuncture. N = 31.
1-7 days - drug treatment and physical treatment.
8-14 days - physical treatment and massage and acupuncture treatment.
Wang 2004 (Continued)
14-30 days - physical treatment and massage and acupuncture treatment.
- Drug treatment (cortisone for 30 mg daily in the morning or 10 mg 3 x daily for 7 days, decreased the
dosage on the 7th day, and stop on the 14th day; mexobalamin 500 ug 2 x daily; vitamin B2 10 mg).
Outcomes Scores of facial muscular function: Potmann Scores (frowning, eyes closing, moving nose, smiling,
whistling, and plumping the face, each movement graded 3 scores, adding 2 scores for the impression of
quiet state).
There was no exact criterion to measure the symptoms.
Notes
Risk of bias
Allocation concealment? Yes A - Adequate. Randomised numbers by the com-
puter.
Wen 2004
Methods Blinding: none.
Analysis: each group has patients with three different severities: mild, moderate and severe. The degree of
recovery, time to recovery and complications were used to evaluate the results.
Follow up: during the treatment = 12 weeks (between 10/2000 and 11/2003).
Center: central Hospital of Nanyanz, Manyang, Henan Province, China.
Design: controlled randomised trial.
Participants N = 145 people with idiopathic facial palsy.
Diagnosis: severity based on the function of facial muscles and complaints of patients.
Duration: not mentioned.
Gender: both sexes males 85 and females 60.
Age: 7 to 74 years old (average: 45).
Setting: hospital.
History/Comorbidities: not mentioned.
Interventions 1. Conventional therapy plus facial rehabilitation exercises (movements using facial muscles, exercises
performed daily under the tutoring of clinicians). N = 85
2. Conventional therapy only. N = 60.
Both groups received the same pharmacological treatment (no information about the dosage that was
used).
Outcomes Grade of paralysis estimated visually as a percentage of the function of the normal side.
The outcome measures were times when the patient started to recover and completely recovered; the
percentage of completely recovered patients within 12 weeks.
The measurements took place once a week by clinicians but the results were presented as standard mean
differences. No baseline level was indicated.
Wen 2004 (Continued)
Notes Facial muscle synkineses were reported in one case in the mild and one in the moderate group. In the
severe patient group, 12 cases of complications reported in the control group and 4 cases in the training
group were reported.
Risk of bias
Allocation concealment? Unclear B - Unclear. Allocation not mentioned.
Characteristics of excluded studies [ordered by study ID]
Aleev 1973 Not a randomised controlled trial. It is a case series.
Balliet 1982 Not a randomised controlled trial. Four people with traumatic facial paralysis.
Bernardes 2004 Not a -randomised controlled trial. It is a retrospective study to delineate the contribution of myofunctional
exercises during the accid phase of the facial paralysis between participants with traumatic and spontaneous
paralysis.
Beurskens 2004c This is a description of the mime facial exercises.
Brach 1999 Not a randomised controlled trial. It is a case study that proposed a treatment-based category based on signs
and symptoms.
Brown 1978 Not a randomised controlled trial. It is a case study that described two participants treated with biofeedback in
both clinic and home environment.
Casler 1990 This is a controlled trial about surgery.
Coulson 2006 There were only two participants with idiopathic facial palsy.
Coulson 2006b Not a randomised controlled trial. It is a study of 2 cases following removal of a vestibular schwannoma.
Cronin 2003 Not a randomised controlled trial. This is a retrospective case review. There are others causes of facial palsy
including Ramsay Hunt. There were only 3 participants with idiopathic facial palsy. The groups were not
comparable at baseline. Twenty-four participants received neuromuscular facial retraining and the other 6 were
the control group.
Dalla-Toffola 2005 Not a randomised controlled trial. This is a retrospective study.
Danile 1982 Not a randomised controlled trial. Iontophoresis was applied in 50 participants with idiopathic facial palsy
without a comparison group.
(Continued)
Dubravica 1996 It was unclear howthe groups were divided and if the participants were randomised. The two groups undertook
kinesiotherapy plus electrostimulation 5 weeks before the study and it could have interfered with the results.
Goulart 2002 Not a randomised controlled trial. It is a non-systematic review of the literature.
Klingler 1982 This controlled trial is about therapy with cortisone, anti-rheumatics and diuretics to treat facial palsy
Koyama 2005 Not a randomised controlled trial.
Lobzin 1989 Not a randomised controlled trial. This is two studies with 32 participants with neuritis and neuropathy of the
facial nerve treated with an electromyography feedback device without a comparison group.
Manca 1997 Not a randomised controlled trial. It is a study of 20 participants with facial paralysis treated with EMG
biofeedback.
Murakami 1993 Not a randomised trial. One group of people treated with low reactive-level laser therapy (11) compared with
one group treated with stellate ganglion block (26) and another group with a combination of both (15).
Nakamura 2003 There were only 10 participants with idiopathic facial palsy. 27 people with complete facial nerve palsy who had
no response to electrical stimulation were randomly allocated into 2 groups: 12 treated with training method
of biofeedback rehabilitation to prevent synkinesis and 15 as a control without treatment.
Romero 1982 Not a randomised controlled trial. Biofeedback training was applied in ten participants with at least one-year
evolution selected in 957 facial paralyses. Only six of them had idiopathic facial palsy.
Ross 1991 This study describes a randomised controlled trial with 31 people with long standing facial paresis (minimum
of 18 months) but there were only four participants with idiopathic facial palsy.
Segal 1995a Not a randomised controlled trial. It is a preliminary study with 10 participants.
This compared a neuromuscular retraining program (5 participants)to a group with the same treatment plus
small movements to limit synkinesis (5 participants). There was one person that did not have idiopathic facial
palsy and it is not possible to analyse the data excluding this participant.
Segal 1995b Not a randomised controlled trial. It was a study of 25 people (5 with idiopathic paralysis)that proposed an
exercise program based on home exercises and weekly 50 to 60 minute sessions at the clinic. Reassessment was
made at 2.5 month intervals for up to 10 months with the House scale and synkinesis measure. All idiopathic
participants changed from House grade 4 to 3 in 5 to 10 months.
Shiau 1995 Not a randomised controlled trial. The assessment was randomised and not the participants.
Taverner 1966 This is a randomised clinical trial about adrenocorticotrophic hormone injections .
Zhao 2005 This controlled trial is about stellate ganglion block and acupuncture.
* EMG = Electromyography
Characteristics of studies awaiting assessment [ordered by study ID]
Diao 2002
Methods Not known
Participants Not known
Interventions Not known
Outcomes Not known
Notes Not known
Guo 2006
Methods Not known
Outcomes Not known
Notes Not known
Li 2005
Methods Randomised design. Sample size = 94 (withdrawals: unclear). Experimental Group: 48 acupuncture. Control Group:
46 manipulation. Treatment follow up: after the fourth treatment session.Treatment duration: 7 x 4 days.
Participants Inclusion: participants with Bells palsy dened according to clinical diagnostic criteria of all degrees of severity. Aged
from 6 to 65, mean age: unclear.Male 43, female 51.
Interventions Experimental group: treatment with acupuncture, ve days per week with two rest days. Control group: treatment
with manipulation, ve days per week. Size of needles: unclear.Total number of sites: 11. Length of application: 20
minutes. Length of session: 1 week.Total number of treatment sessions: 4.
Outcomes Cured (disappearance of all signs and symptoms, the facial symmetry and the function of mimetic muscle were
fully restored after treatment). Markedly effective (the facial symmetry was normal in repose, however, during
movement, low-grade paralysis persisted after treatment). Improved (the facial symmetry was improved, however,
during movement, paralysis persisted after treatment). No effect (signs and symptoms unchanged after treatment).
Notes Experimental group: Cured: 30; Markedly effective:12; Improved:6; No effect:0. Control group: Cured: 29; Markedly
effective: 13; Improved: 4; No effect:0.
These data were extracted from He 2007.
Pan 2004
Methods Not known
Outcomes Not known
Notes Not known
Qu 2005
Methods Not known
Outcomes Not known
Notes Not known
Wang 2004b
Methods Not known
Outcomes Not known
Notes Not known
Yang 2001
Methods Not known
Outcomes Not known
Notes Not known
Zhang 2005
Methods Not known
Outcomes Not known
Notes Not known
D A T A A N D A N A L Y S E S
Comparison 1. ELECTROSTIMULATION VERSUS CONTROL
Outcome or subgroup title
No. of
studies
No. of
participants
Statistical method Effect size
1 Incomplete recovery after 6 and
12 months
1 Risk Ratio (M-H, Random, 95% CI) Totals not selected
1.1 6 months 1 Risk Ratio (M-H, Random, 95% CI) Not estimable
1.2 12 months 1 Risk Ratio (M-H, Random, 95% CI) Not estimable
2 Mean Facial Grading Scale after
3 months
1 Mean Difference (IV, Fixed, 95% CI) Totals not selected
2.1 Rest score 1 Mean Difference (IV, Fixed, 95% CI) Not estimable
2.2 Movement score 1 Mean Difference (IV, Fixed, 95% CI) Not estimable
2.3 Total score 1 Mean Difference (IV, Fixed, 95% CI) Not estimable
Comparison 2. ELECTROSTIMULATION VERSUS PREDNISONE
No. of
studies
No. of
participants
1 Incomplete recovery after six
months (all participants)
1 Risk Ratio (M-H, Fixed, 95% CI) Totals not selected
2 Incomplete recovery six months
according severity
1 Risk Ratio (M-H, Fixed, 95% CI) Totals not selected
2.1 Infrachordal lesion (mild
cases)
1 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
2.2 Suprachordal lesion
(severe cases)
1 Risk Ratio (M-H, Fixed, 95% CI) Not estimable
3 Mean time to complete recovery
(in days)
1 149 Mean Difference (IV, Fixed, 95% CI) -8.38 [-13.99, -2.77]
3.1 Infrachordal lesion (mld
cases)
3.2 Suprachordal lesion
(severe cases)
1 47 Mean Difference (IV, Fixed, 95% CI) -33.94 [-63.40, -
4.48]
Comparison 3. EXERCISE VERSUS WAITING LIST
No. of
studies
No. of
participants
1 Recovery on Facial Grading
Scale (Sunnybrook scale)
2 Recovery on Facial Disability
Index-physical
2.1 FDI-physical 1 Mean Difference (IV, Fixed, 95% CI) Not estimable
2.2 FDI-social 1 Mean Difference (IV, Fixed, 95% CI) Not estimable
Comparison 4. EXERCISE VERSUS CONVENTIONAL TREATMENT
No. of
studies
No. of
participants
1 Incomplete recovery three
months after randomisation
1 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
2 Mean time from the beginning
of the recovery (in weeks)
2.1 Participants with mild
paralysis
1 43 Mean Difference (IV, Fixed, 95% CI) -0.30 [-0.79, 0.19]
2.2 Participants with moderate
paralysis
3 Mean time from completion of
recovery (in weeks)
3.1 Participants with mild
paralysis
1 43 Mean Difference (IV, Fixed, 95% CI) -0.40 [-1.09, 0.29]
3.2 Participants with moderate
paralysis
4 Potmann Score 1 Mean Difference (IV, Fixed, 95% CI) Totals not selected
Analysis 1.1. Comparison 1 ELECTROSTIMULATION VERSUS CONTROL, Outcome 1 Incomplete
recovery after 6 and 12 months.
Review: Physical therapy for Bells palsy (idiopathic facial paralysis)
Comparison: 1 ELECTROSTIMULATION VERSUS CONTROL
Outcome: 1 Incomplete recovery after 6 and 12 months
Study or subgroup Electrotherapy Massage + IV Risk Ratio Risk Ratio
n/N n/N M-H,Random,95% CI M-H,Random,95% CI
1 6 months
Mosforth 1958 15/44 11/42 1.30 [ 0.68, 2.50 ]
2 12 months
Mosforth 1958 12/44 10/42 1.15 [ 0.55, 2.36 ]
0.2 0.5 1 2 5
Favours treatment Favours control
Analysis 1.2. Comparison 1 ELECTROSTIMULATION VERSUS CONTROL, Outcome 2 Mean Facial
Grading Scale after 3 months.
Comparison: 1 ELECTROSTIMULATION VERSUS CONTROL
Outcome: 2 Mean Facial Grading Scale after 3 months
Study or subgroup Electrical Stimulation Control Mean Difference Mean Difference
N Mean(SD) N Mean(SD) IV,Fixed,95% CI IV,Fixed,95% CI
1 Rest score
Manikandan 2007 28 5 (5) 28 5 (4.5) 0.0 [ -2.49, 2.49 ]
2 Movement score
Manikandan 2007 28 74 (14) 28 6 (16.7) 68.00 [ 59.93, 76.07 ]
3 Total score
Manikandan 2007 28 66 (22) 28 54 (18.9) 12.00 [ 1.26, 22.74 ]
-100 -50 0 50 100
Favours electro Favours control
Analysis 2.1. Comparison 2 ELECTROSTIMULATION VERSUS PREDNISONE, Outcome 1 Incomplete
recovery after six months (all participants).
Comparison: 2 ELECTROSTIMULATION VERSUS PREDNISONE
Outcome: 1 Incomplete recovery after six months (all participants)
Study or subgroup Electrostimulation Prednisone Risk Ratio Risk Ratio
n/N n/N M-H,Fixed,95% CI M-H,Fixed,95% CI
Flores 1998 10/77 11/72 0.85 [ 0.38, 1.88 ]
0.01 0.1 1 10 100
Analysis 2.2. Comparison 2 ELECTROSTIMULATION VERSUS PREDNISONE, Outcome 2 Incomplete
recovery six months according severity.
Outcome: 2 Incomplete recovery six months according severity
Study or subgroup Electrostimulation Prednisone Risk Ratio Risk Ratio
1 Infrachordal lesion (mild cases)
Flores 1998 0/47 0/55 0.0 [ 0.0, 0.0 ]
2 Suprachordal lesion (severe cases)
Flores 1998 11/30 10/17 0.62 [ 0.34, 1.15 ]
0.1 0.2 0.5 1 2 5 10
Favours electro Favours prednisone
Analysis 2.3. Comparison 2 ELECTROSTIMULATION VERSUS PREDNISONE, Outcome 3 Mean time to
complete recovery (in days).
Outcome: 3 Mean time to complete recovery (in days)
Study or subgroup Electrostimulation Prednisone Mean Difference Weight Mean Difference
1 Infrachordal lesion (mld cases)
Flores 1998 47 22.78 (8.92) 55 30.2 (19.35) 96.4 % -7.42 [ -13.13, -1.71 ]
Subtotal (95% CI) 47 55 96.4 % -7.42 [ -13.13, -1.71 ]
Heterogeneity: not applicable
Test for overall effect: Z = 2.54 (P = 0.011)
2 Suprachordal lesion (severe cases)
Flores 1998 30 81.56 (44.53) 17 115.5 (52.13) 3.6 % -33.94 [ -63.40, -4.48 ]
Subtotal (95% CI) 30 17 3.6 % -33.94 [ -63.40, -4.48 ]
Total (95% CI) 77 72 100.0 % -8.38 [ -13.99, -2.77 ]
Heterogeneity: Chi
2
= 3.00, df = 1 (P = 0.08); I
2
=67%
Test for subgroup differences: Chi
2
= 3.00, df = 1 (P = 0.08), I
2
=67%
-100 -50 0 50 100
Analysis 3.1. Comparison 3 EXERCISE VERSUS WAITING LIST, Outcome 1 Recovery on Facial Grading
Scale (Sunnybrook scale).
Comparison: 3 EXERCISE VERSUS WAITING LIST
Outcome: 1 Recovery on Facial Grading Scale (Sunnybrook scale)
Study or subgroup Treatment Control Mean Difference Mean Difference
Beurskens 2003 16 54.9 (18.2) 18 34.5 (16.2) 20.40 [ 8.76, 32.04 ]
-50 -25 0 25 50
Favours control Favours exercises
Analysis 3.2. Comparison 3 EXERCISE VERSUS WAITING LIST, Outcome 2 Recovery on Facial Disability
Index-physical.
Comparison: 3 EXERCISE VERSUS WAITING LIST
Outcome: 2 Recovery on Facial Disability Index-physical
Study or subgroup Exercises Control Mean Difference Mean Difference
1 FDI-physical
Beurskens 2003 16 73.5 (16.8) 18 63.2 (17.9) 10.30 [ -1.37, 21.97 ]
2 FDI-social
Beurskens 2003 16 80.7 (12.2) 18 66.2 (16.4) 14.50 [ 4.85, 24.15 ]
-20 -10 0 10 20
Favours control Favours exercises
Analysis 4.1. Comparison 4 EXERCISE VERSUS CONVENTIONAL TREATMENT, Outcome 1 Incomplete
recovery three months after randomisation.
Comparison: 4 EXERCISE VERSUS CONVENTIONAL TREATMENT
Outcome: 1 Incomplete recovery three months after randomisation
Study or subgroup Facial exercise Control Risk Ratio Risk Ratio
Wen 2004 6/85 7/60 0.61 [ 0.21, 1.71 ]
0.1 0.2 0.5 1 2 5 10
Analysis 4.2. Comparison 4 EXERCISE VERSUS CONVENTIONAL TREATMENT, Outcome 2 Mean time
from the beginning of the recovery (in weeks).
Outcome: 2 Mean time from the beginning of the recovery (in weeks)
Study or subgroup Facial exercise Control Mean Difference Weight Mean Difference
1 Participants with mild paralysis
Wen 2004 24 2.1 (0.7) 19 2.4 (0.9) 73.7 % -0.30 [ -0.79, 0.19 ]
Subtotal (95% CI) 24 19 73.7 % -0.30 [ -0.79, 0.19 ]
2 Participants with moderate paralysis
Wen 2004 31 4.1 (1.3) 16 5.5 (1.4) 26.3 % -1.40 [ -2.22, -0.58 ]
Subtotal (95% CI) 31 16 26.3 % -1.40 [ -2.22, -0.58 ]
Total (95% CI) 55 35 100.0 % -0.59 [ -1.01, -0.17 ]
Heterogeneity: Chi
2
= 5.04, df = 1 (P = 0.02); I
2
=80%
2
= 5.04, df = 1 (P = 0.02), I
2
=80%
-10 -5 0 5 10
Analysis 4.3. Comparison 4 EXERCISE VERSUS CONVENTIONAL TREATMENT, Outcome 3 Mean time
from completion of recovery (in weeks).
Outcome: 3 Mean time from completion of recovery (in weeks)
Study or subgroup Facial exercise Control Mean Difference Weight Mean Difference
1 Participants with mild paralysis
Wen 2004 24 3.8 (1.2) 19 4.2 (1.1) 69.7 % -0.40 [ -1.09, 0.29 ]
Subtotal (95% CI) 24 19 69.7 % -0.40 [ -1.09, 0.29 ]
2 Participants with moderate paralysis
Wen 2004 31 7.2 (1.8) 16 9.3 (1.7) 30.3 % -2.10 [ -3.15, -1.05 ]
Subtotal (95% CI) 31 16 30.3 % -2.10 [ -3.15, -1.05 ]
Total (95% CI) 55 35 100.0 % -0.91 [ -1.49, -0.34 ]
Heterogeneity: Chi
2
= 7.07, df = 1 (P = 0.01); I
2
=86%
2
= 7.07, df = 1 (P = 0.01), I
2
=86%
-10 -5 0 5 10
Analysis 4.4. Comparison 4 EXERCISE VERSUS CONVENTIONAL TREATMENT, Outcome 4 Potmann
Score.
Outcome: 4 Potmann Score
Study or subgroup Facial exercise Control Mean Difference Mean Difference
Wang 2004 43 18.72 (1.77) 31 10.25 (3.75) 8.47 [ 7.05, 9.89 ]
-10 -5 0 5 10
Favours control Favours treatment
A P P E N D I C E S
Appendix 1. MEDLINE search strategy
1. exp facial nerve diseases/
2. bell palsy/
3. facial paralysis/or hemifacial paralysis/
4. ((bell$ or facial$ or hemifacial$ or unilateral$ or nerve$ or cranial$) adj3 (pals$ or paralys$ or paresi$ or spasm$)).mp.
5. or/1-4
6. exp exercise movement techniques/or exp physical therapy modalities/
7. physical therapy.mp.
8. physio$.mp.
9. rehabilitation.mp.
10. exp Rehabilitation/
11. exercise$ therapy.mp.
12. Physical Fitness/
13. physical tness.mp.
14. Motor Activity/
15. physical activit$.mp.
16. kinesiotherapy.mp.
17. stretch$.mp.
18. strengthen$.mp.
19. Physical Endurance/
20. endurance.mp.
21. Biofeedback (Psychology)/
22. biofeedback.mp.
23. Electromyography/
24. electromyography.mp.
25. electromyogram$.mp.
26. short-wave therapy/ or ultrasonic therapy/
27. (ultrasonic therapy or short wave therapy).mp.
28. Lasers/
29. laser$.mp.
30. iontophor$.mp.
31. manipulat$.mp
32. Cryotherapy/
33. cryotherap$.mp.
34. or/6-33
35. 34 and 5
36. randomized controlled trial.pt.
37. controlled clinical trial.pt.
38. randomized controlled trials/
39. random allocation/
40. double-blind method/
41. single-blind method/
42. or/36-41
43. animals/ not humans/
44. 42 not 43
45. clinical trial.pt.
46. exp clinical trials/
47. (clin$ adj25 trial$).ti,ab.
48. ((singl$ or doubl$ or tripl$ or trebl$) adj25 (blind$ or mask$)).ti,ab.
49. placebos/
50. placebo$.ti,ab.
51. random$.ti,ab.
52. research design/
53. or/45-52
54. 53 not 43
55. 54 not 44
56. comparative study/
57. exp evaluation studies/
58. follow up studies/
59. prospective studies/
60. (control$ or prospectiv$ or volunteer$).ti,ab.
61. or/56-60
62. 61 not 43
63. 62 not (44 or 55)
64. 44 or 55 or 63
65. 35 and 64
Appendix 2. EMBASE search strategy
1. exp nerve paralysis/
2. bell palsy/
3. facial nerve paralysis/or hemifacial spasm/
4. ((bell$ or facial$ or hemifacial$ or unilateral$ or nerve$ or cranial$) adj3 (pals$ or paralys$ or paresi$ or spasm$)).mp.
5. or/1-4
6. exp physiotherapy/or exp kinesiotherapy/
7. physical therapy.mp.
8. physio$.mp.
9. rehabilitation.mp.
10. exp Rehabilitation/
11. exercise$ therapy.mp.
12. Fitness/
13. physical tness.mp.
14. Motor Activity/
15. physical activit$.mp.
16. kinesiotherapy.mp.
17. stretch$.mp.
18. strengthen$.mp.
19. Physical Stress/
20. endurance.mp.
21. psychophysiology/
22. biofeedback.mp.
23. Electromyography/
24. electromyography.mp.
25. electromyogram$.mp.
26. diathermy/or ultrasound therapy/
27. (ultrasonic therapy or short wave therapy).mp.
28. Laser/
29. laser$.mp.
30. iontophor$.mp.
31. manipulat$.mp.
32. Cryotherapy/
33. cryotherap$.mp.
34. or/6-33
35. 34 and 5
36. Randomized Controlled Trial/
37. Clinical Trial/
38. Multicenter Study/
39. Controlled Study/
40. Crossover Procedure/
41. Double Blind Procedure/
42. Single Blind Procedure/
43. exp RANDOMIZATION/
44. Major Clinical Study/
45. PLACEBO/
46. Meta Analysis/
47. phase 2 clinical trial/ or phase 3 clinical trial/ or phase 4 clinical trial/
48. (clin$ adj25 trial$).tw.
49. ((singl$ or doubl$ or tripl$ or trebl$) adj25 (blind$ or mask$)).tw.
50. placebo$.tw.
51. random$.tw.
52. control$.tw.
53. (meta?analys$ or systematic review$).tw.
54. (cross?over or factorial or sham? or dummy).tw.
55. ABAB design$.tw.
56. or/36-55
57. human/
58. nonhuman/
59. 57 or 58
60. 56 not 59
61. 56 and 57
62. 60 or 61
63. 35 and 62
Appendix 3. EBSCOhost CINHAL search strategy
S45 S44 and S26
S44 S43 or S42 or S41 or S40 or S39 or S38 or S37 or S36 or S35 or S34 or S33 or S32 or S31 or S30 or S29 or S28 or S27
S43 TI random* or AB random*
S42 ( TI (cross?over or placebo* or control* or factorial or sham? or dummy) ) or ( AB (cross?over or placebo* or control* or factorial
or sham? or dummy) )
S41 ( TI (clin* or intervention* or compar* or experiment* or preventive or therapeutic) or AB (clin* or intervention* or compar* or
experiment* or preventive or therapeutic) ) and ( TI (trial*) or AB (trial*) )
S40 ( TI (meta?analys* or systematic review*) ) or ( AB (meta?analys* or systematic review*) )
S39 ( TI (single* or doubl* or tripl* or trebl*) or AB (single* or doubl* or tripl* or trebl*) ) and ( TI (blind* or mask*) or AB (blind*
or mask*) )
S38 ARAB design*
S37 PT clinical trial or PT systematic review
S36 (MH Factorial Design)
S35 (MH Concurrent Prospective Studies) or (MH Prospective Studies)
S34 (MH Meta Analysis)
S33 (MH Solomon Four-Group Design) or (MH Static Group Comparison)
S32 (MH Quasi-Experimental Studies)
S31 (MH Placebos)
S30 (MH Double-Blind Studies) or (MH Triple-Blind Studies)
S29 (MH Clinical Trials+)
S28 (MH Crossover Design)
S27 (MH Random Assignment) or (MH Random Sample) or (MH Simple Random Sample) or (MH Stratied Random
Sample) or (MH Systematic Random Sample)
S26 S25 and S3
S25 S24 or S23 or S22 or S21 or S20 or S19 or S18 or S17 or S16 or S15 or S14 or S13 or S12 or S11 or S10 or S9 or S8 or S7 or S6
or S5 or S4
S24 cryotherap*
S23 (MH Cryotherapy)
S22 manipulat*
S21 iontophor*
S20 (MH Lasers) or laser*
S19 (MH Ultrasonic Therapy) or ultrasonic therapy or short-wave therapy
S18 electromyogram*
S17 (MH Electromyography) or electromyography
S16 (MH Biofeedback) or biofeedback
S15 enduranc*
S14 (MH Physical Endurance)
S13 strengthen*
S12 stretch*
S11 kinesiotherapy
S10 physical activit*
S9 (MH Motor Activity)
S8 (MH Physical Fitness) or physical tness
S7 exercise therap*
S6 (MH Rehabilitation+) or rehabilitation
S5 physical therap* or physio*
S4 ((MH Physical Therapy+)) or (MH Therapeutic Exercise+)
S3 S2 or S1
S2 (bell* or facial* or hemifacial* or unilateral* or nerv* or cranial*) and (pals* or parayls* or paresi* or spasm*)
S1 ((MH Bell Palsy) or (MH Facial Nerve Diseases+)) or (MH Facial Paralysis)
Appendix 4. LILACS search strategy
((Pt ENSAIO CONTROLADO ALEATORIO OR Pt ENSAIO CLINICO CONTROLADO OR Mh ENSAIOS CONTROLA-
DOS ALEATORIOS OR Mh DISTRIBUICAO ALEATORIA OR Mh MTODO DUPLO-CEGO OR Mh MTODO SIM-
PLES-CEGO) AND NOT (Ct ANIMAIS AND NOT (Ct HUMANO AND Ct ANIMAIS)) OR (Pt ENSAIO CLNICO OR Ex
E05.318.760.535$) OR (Tw clin$ AND (Tw trial$ OR Tw ensa$ OR Tw estud$ OR Tw experim$ OR Tw investiga$)) OR ((Tw
singl$ OR Tw simple$ OR Tw doubl$ OR Tw doble$ OR Tw duplo$ OR Tw trebl$ OR Tw trip$) AND (Tw blind$ OR Tw cego$
OR Tw ciego$ OR Tw mask$ OR Tw mascar$)) OR Mh PLACEBOS OR Tw placebo$ OR (Tw random$ OR Tw randon$ OR
Tw casual$ OR Tw acaso$ OR Tw azar OR Tw aleator$) OR (Mh PROJETOS DE PESQUISA) AND NOT (Ct ANIMAIS AND
NOT (Ct HUMANO AND Ct ANIMAIS)) OR (Ct ESTUDO COMPARATIVO OR Ex E05.337$ OR Mh SEGUIMENTOS
OR Mh ESTUDOS PROSPECTIVOS OR Tw control$ OR Tw prospectiv$ OR Tw volunt$ OR Tw volunteer$) AND NOT (Ct
ANIMAIS AND NOT (Ct HUMANO AND Ct ANIMAIS))) [Palavras] and PARALYSIS$ or (INFLAMMATORY MONONEU-
ROPATH$) or (PERIPHERAL NERVOUS SYSTEM DISEASE$) or (HERPES ZOSTER) or NEURALGIA$ or HERPETIC or
POSTHERP$ or POST-HERP$ or (DIABETIC NEUROPATH$) or NEURITIS$ or (PERIPHERAL NERVES$) or (NERVE
TRAUMA) or (NERVE GRAFT) or (NERVE COMPRESSION SYNDROME$) or (ENTRAPMENT NEUROPATH$) or (BELL
PALSY) or (FACIAL PARALYSIS) or (CRANIAL NERVE PALSY) or (FACIAL NERVE INJUR$) or (FACIAL NERVE DISEASE)
[Palavras] and (PHYSICAL THERAPY) or PHYSIOTHERAPY or REHABILITATION or (EXERCISE THERAPY) or (PHYSICAL
EDUCATION TRAINING) or (PHYSICAL FITNESS) or (PHYSICAL ACTIVIT$) or KINESIOTHERAP$ or STRETCHING
or STRENGTHENING or ENDURANCE or BIOFEEDBACK or ELECTROMYOGRAPHY or ELECTROMYOGRAPHY$ or
ELECTROMYOGRAM$ or BIOFEEDBACK or ULTRASON$ or LASER$ or (SHORT WAVE THERAPY) or IONTOPHOR$
or MANIPULAT$ or CRYOTHERAPY [Palavras]
Appendix 5. PEDro search strategy
Abstract & Titles: facial palsy
Therapy: no selection
Body part: no selection
Subdiscipline: no selection
Method: no selection
When searching: match all search terms (AND)
H I S T O R Y
Protocol rst published: Issue 3, 2006
Review rst published: Issue 3, 2008
19 March 2008 Amended Converted to new review format.
C O N T R I B U T I O N S O F A U T H O R S
LJT suggested the review, reviewed the literature wrote the primary version of the protocol and the review.
VPV revised the protocol, the language and the search strategy.
BGOS supervised the process of the protocol development and made contributions about the methodology.
GFP gave specialist contributions.
All authors approved the nal text of the review.
D E C L A R A T I O N S O F I N T E R E S T
None known.
I N D E X T E R M S
Medical Subject Headings (MeSH)
Physical Therapy Modalities; Bell Palsy [
therapy]; Electric Stimulation Therapy [methods]; Exercise Therapy [methods]; Facial

Muscles; Massage [methods]; Randomized Controlled Trials as Topic
MeSH check words
Humans

Physical Therapy For Bell S Palsy (Idiopathic Facial Paralysis) (Review)

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Physical Therapy For Bell S Palsy (Idiopathic Facial Paralysis) (Review)

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Physical therapy for Bell s palsy (idiopathic facial paralysis)

Beurskens CHG, Heymans PG. Positive effects of mime therapy

Lobzin VS, Smetankin AA, Tsatskina ND, Iashin NS. Treatment

Indicates the major publication for the study

Physical Therapy Modalities; Bell Palsy [

therapy]; Electric Stimulation Therapy [methods]; Exercise Therapy [methods]; Facial

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