Professional Documents
Culture Documents
TECHNIQUES FOR
CAPSULES AND LIQUID
ORALS
Materials
Method of production
Filling equipment
Materials:
Gelatin
Plasticizers
Colorants
Opacifying agents
Preservative
Water
Plasticizer:
-
Colorants:
Soluble dyes
Insoluble dyes
Opacifying Agents:
Water:
Cooled to solidify
Air dry
Mill to size
10% Lime
4-8 weeks
Lime removal
pH adjustment
Hot water extraction
Filter
Vacuum concentration
Cooled to solidify
Air dry
Mill to size
Cooled to solidify
Air dry
Mill to size
Size of Capsules:
20 minim oblong
16 minim oval
9 minim round
Filling equipments:
Filling operations:
Empty capsules
Formulation
Finishing
Processing conditions:
Evaluation of Capsules:
Following are the tests that should be carried out
for evaluation of the capsules
Uniformity of weight
Content of the active ingredients in the
capsules
Disintegration Test
Dissolution Test
Production considerations in
Liquid Orals:
Tank Selection
Mixing and Dispersion
Filtration and Clarification
Transfer and Filling
Preservative Evaluation
Tank Selection:
Tank Selection:
Preservative Evaluation:
References:
The Theory and Practice of Industrial Pharmacy
2nd Edition by Lieberman and Lachman
Pharmaceutical Sciences by Remington
Pharmaceutical Sciences by Cooper
Pharmaceutical Sciences by Tucker and Hayes
Pharmaceutical Sciences by Tucker and
Rednick
Thank you