CRITICAL APPRAISAL

1a.

Was there an independent, blind comparison with a reference (gold) standard of

diagnosis?

YES

1b.
YES

Were the groups similar at the start of the trial?

2a.

Aside from the allocated treatment, were groups treated equally?

YES

2b.
Were all patients who entered the trial accounted for? and were they analysed in the
groups to which they were randomised?
YES

3.
Were measures objective or were the patients and clinicians kept blind to which
treatment was being received?
NO

What were the results?

1. How large was the treatment effect?
OUTCOME
7-DAY
14-DAY

51 (a)
55 (c)

EER =

= 0,92

CER =

=1

Relative Risk (RR) =

4 (b)
0 (d)

TOTAL
55 (a+b)
55 (c+d)

= 0,92 x 1 = 0,92

Absolute Risk Reduction (ARR) = CER EER =

Number Needed to Treat (NNT) =

= 0,92 1 = 0,08
= 12,5

2. How precise was the estimate of the treatment effect?

Will the results help me in caring for my patient? (ExternalValidity/Applicability)

1. Is the treatment feasible in my setting?

2. Will the potential benefits of treatment outweigh the potential harms of treatment for my
patient?
Pada penelitian ini, 14 hari pengobatan dengan triple terapi (PPI, amoxicillin dan
clarithromycin) lebih memberi hasil yang memuaskan karena mendekati 100% untuk
menghilangkan bakteri helicobacter pylori tersebut