TOM FRANCIS D.

SARGENTO
BSN-IV
GROUP II
DRUG NAME

CLASSIFICAT
ION

MECHANISM
OF ACTION

INDICAITON

CONTRAINDICA
TION

ADVERSE
REACTION

Midazolam

Benzodiazepin
e (shortacting)
CNS
depressant

Exact
mechanism of
action not
understood;
acts mainly at
the limbic
system and
reticular
formation;
potentiates
the effects of
GABA, an
inhibitory
neurotransmitt
er; anxiolytic
and amnesia
effects occur
at doses below
those needed
to cause
sedation,
ataxia; has
little effect on
cortical

Midazolam is
indicated for
use in
pediatric
patients for
sedation,
anxiolysis
and amnesia
prior to
diagnostic,
therapeutic
or endoscopic
procedures or
before
induction of
anesthesia.

Contraindicat
ed with
hypersensitiv
ity to
benzodiazepi
nes;
psychoses,
acute
narrow-angle
glaucoma,
shock, coma,
acute
alcoholic
intoxication;
pregnancy;
neonates.
Use
cautiously in
elderly or
debilitated
patients;
with
impaired
liver or renal

Blurred vision;
changes in
blood
pressure,
breathing,
and
heartbeats;
coughing;
dizziness;
drowsiness;
dry mouth;
headache;
hiccups; low
blood
pressure
(children);
nausea; pain
during
injection;
pain, redness,
or tenderness
at the
injection site;
short-term
memory loss;
slurred
speech;
vomiting.

NURSING
RESPONSIBILI
TY
Do not
use small
veins for IV
injection.
Administ
er IM
injections
deep into
muscle.
Monitor
IV injection
site for
extravasati
on.
Arrange
to reduce
dosage of
midazolam
if patient is
also being
given
oploid
analgesics;
reduce

function.

function,
lactation.

Severe
allergic
reactions
(rash; hives;
difficulty
breathing;
tightness in
the chest;
swelling of the
mouth, face,
lips, or
tongue);
agitation;
chest pain;
combativenes
s; irregular
breathing
patterns;
pain, swelling,
or redness at
the injection
site; slow or
difficult
breathing;
unusual or
involuntary
muscle
movements or
muscle
tremor.

dosage by
at least
50% and
monitor
patient
closely.
Monitor
level of
consciousn
ess before,
during, and
for at least
2-6 hr after
administrati
on of
midazolam.
Carefully
monitor P,
BP, and
respirations
during
administrati
on.