Neuromuscular Blocking Agents

DISTINCTIONS BETWEEN DEPOLARIZING &

NONDEPOLARIZING BLOCKADE
Neuromuscular blocking agents are divided into two classes,
1. depolarizing and
2. nondepolarizing.
This division reflects distinct differences in,
the mechanism of action,
response to peripheral nerve stimulation,
and reversal of block.

NONDEPOLARIZING MUSCLE RELAXANTS

Unique Pharmacological Characteristics
Chemically they are either benzylisoquinolines or steroidal compounds.S
-

steroidal compounds tend to be vagolytic,

whereas benzylisoquinolines tend to release histamine.

Because of structural similarities, an allergic history to one muscle relaxant strongly

suggests the possibility of allergic reactions to other muscle relaxants.