Professional Documents
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DIAGRAM
Make a diagram of what you have understood about your assigned work. Choose between myasthenia gravis and muscle
spasm.
MYASTHENIA GRAVIS
Myasthenia Gravis (MG) : is characterized by weakness and rapid fatigue of any of the muscles under your voluntary
control. The cause of myasthenia gravis is a breakdown in the normal communication between nerves and muscles.
There is no cure for myasthenia gravis, but treatment can help relieve signs and symptoms — such as weakness
of arm or leg muscles, double vision, drooping eyelids, and difficulties with speech, chewing, swallowing and
breathing.
Nursing management: Provide rest in-between nursing care interventions.
o Admin. Meds on time and evenly spaced intervals to prevent relapse.
o Make the most of energy peaks.
o Plan diet and food intake around ability to swallow.
o Stress need for frequent rest periods.
o Establish resp. and neuro. Baseline.
Medical Management
o Mestinon: Orally active cholinesterase inhibitor. Increases the amount of acetylcholine at the neuromuscular
junction. Enhances Communication between nerves and muscles.
o Corticosteroids- these inhibit the immune system
o Immunosuppressant’s- to alter immune system. ( these can increase risk for infection)
cyclosporine/mycophenolate
o Atropine: for bradycardia. This med will pick up the heart rate.
o Tensilon: trade name for Edrophonium chloride. The tensilon test is an injection used to diagnose MG.
Prolongs the muscle stimulation and temporarily improves strengths, increased strength following an
injection of tensilon suggests a diagnosis of MG.
Muscle Spasm : A disturbance to the normal flow of information in the CNS caused by diseases, infections,
toxins, and injuries can lead to disturbances ranging from spasms to paralysis.
results from violent and painful involuntary muscle contraction usually caused by muscle overstretching, joint
wrenching, and tendon or ligament tearing. When this happens, the injured area floods sensory impulses to
the spinal cord and it responds by eliciting intense muscle contraction. Pain from muscle spasms is due to
lactic acid accumulation that occurs when blood flow is cut off during contractions. Sensory impulses continue
to flood and a vicious cycle of contraction develops.
What causes muscle spasms?
a. Insufficient stretching before physical activity.
b. Muscle fatigue.
c. Exercising in heated temperatures.
d. Dehydration.
e. Electrolyte imbalances in potassium, magnesium and calcium
Muscle spasticity occurs when damaged neurons are within the CNS rather than the peripheral areas. The site of
damage makes this abnormality permanent. There is an interruption in the balance of excitatory and inhibitory
influences within the CNS which can lead to hypertonia (excessive muscle stimulation) and consequent
contractures and structural changes. There is now loss of coordinated muscle activity.
Centrally acting muscle relaxants work in the CNS to interfere with reflexes that cause muscle spasms. They
essentially destroy or lyse spasms and are often referred to as spasmolytics.
Other modalities of spasm and pain relief like rest, heat application, and physical therapy are used in addition
to these drugs.
Therapeutic Action : The exact mechanism of action of skeletal muscle relaxants is not fully understood but it is
thought that it involves the participation of upper or spinal interneurons. It inhibits monosynaptic and polysynaptic
spinal reflexes. Other than that, it is a CNS depressant.
Indications : Primary indication is relief of discomfort associated with acute, painful musculoskeletal conditions as
adjunct to rest, physical therapy, and other measures. Alleviation of signs and symptoms of spasticity, may be of
use in spinal cord injuries or spinal cord diseases.
Contraindications and Cautions
o Allergy to centrally acting skeletal muscle relaxants. Prevent hypersensitivity reactions.
o Skeletal muscle spasms caused by rheumatic disorders. Do not benefit from these drugs.
o History of epilepsy. CNS depression and imbalance caused by drugs may exacerbate seizure disorder.
o Cardiac dysfunction. Muscle function may be depressed.
o Condition marked by muscle weakness. Can be exacerbated by drugs.
o Hepatic, renal dysfunction. Interfere with drug metabolism and excretion.
MUSCLE SPASM
Spasms of skeletal muscles are most common and are often due to overuse and muscle fatigue, dehydration,
and electrolyte abnormalities. The spasm occurs abruptly, is painful, and is usually short-lived. It may be relieved
by gently stretching the muscle.
Direct-Acting Skeletal Muscle Relaxants: enter the muscle to prevent muscle contraction directly.
Therapeutic Action : Dantrolene acts within skeletal muscle fibers and interfere with calcium ion release from the
muscle tubules. Therefore, the fibers are prevented from contracting. It does not interfere with neuromuscular
transmission and does not affect skeletal muscle surface membrane.
Indications
Children
Safety and effectiveness not established in children.
Dantrolene is used to treat upper motor neuron spasticity in children.
Dose should be accurately calculated based on body weight and it increases over time.
Children are at increased risk of CNS and GI toxicity.
Adult
Adverse Effects
o CNS: drowsiness, fatigue, weakness, confusion, headache, insomnia, visual disturbances
o GI: GI irritation, diarrhea, constipation, abdominal cramps
o GU: urinary frequency, enuresis, urinary urgency , crystalline urine with pain or burning on urination
o Others: acne, abnormal hair growth, rashes, photosensitivity, abnormal sweating, chills, nyalgia
o Dantrolene can cause direct hepatocellular damage and potentially fatal hepatitis
o Botulinom toxins are associated with anaphylactic reactions characterized by headache, dizziness, muscle
pain, paralysis
Interactions
o Estrogens: increased incidence of hepatocellular toxicity if used with dantrolene
o Neuromuscular junction blockers, lincosamides, quinidine, magnesium sulphate, anticholinesterase,
succinylcholine, polymyxin, aminoglycosides: increased risk of additive effects
Implementation with Rationale
o Assess area before administering botulinum toxins because area with active infection will be exacerbated by
injection.
o Monitor intravenous access sites of dantrolene for potential extravasation because drug is alkaline and very
irritating to tissues.
o Periodically discontinue dantrolene for 2-4 days as ordered to monitor therapeutic effectiveness.
o Discontinue drug at any sign of liver dysfunction to prevent adverse effects.
o Provide comfort measures to help patient tolerate drug effects.
o Provide safety measures (e.g. adequate lighting, raised side rails, etc.) to prevent injuries.
o Educate client on drug therapy to promote understanding and compliance.
PARKINSON’S DISEASE
Parkinson’s Disease is a chronic, progressive neurological disorder with rhythmic tremors as its initial
manifestation. These tremors lead to rigidity and weakness which interfere with the ability to maintain posture.
Other manifestations include bradykinesia (extremely slowed movements), shuffling gait, drooling, and slow
and slurred speech. Cranial nerve affectations lead to a mask-like expression.
It is important to note that Parkinson’s does not affect the higher levels of cerebral cortex so intelligence and
other brain functions at the same level are intact.
The actual cause of Parkinson’s is not known but the manifestations are directly related to the damaged neurons
in the basal ganglia of the brain. Neuronal damage is thought to be caused by viral infections, head trauma,
brain infections, atherosclerosis, and drug and environmental exposures.
Parkinsonism
Parkinsonism is referred to as the Parkinson’s disease-like extrapyramidal symptoms which are associated to
particular drugs or brain injuries’ adverse effects.
Dopaminergic Agents : Drugs that increase the effects of dopamine at receptor sites.
Therapeutic Action
Dopamine does not cross the blood-brain barrier so other drugs with actions similar to dopamine and those that
increase its concentration in the substantia nigra (area responsible for muscle tone) must be used. This is one
way of restoring the balance between stimulatory and inhibitory neurotransmitters.
Levodopa, the precursor of dopamine is the mainstay of treatment for Parkinson’s. It crosses the blood-brain
barrier and is converted into dopamine. When combined with carbidopa, the enzyme dopa decarboxylase is
inhibited from metabolizing levodopa, leading to higher levels that can cross the barrier.
Indications
Dopaminergics are indicated for the relief of the signs and symptopms of idiopathic Parkinson’s disease.
Levodopa is the drug of choice and acts as a replacement therapy.
Amantadine is an antiviral drug that increases release of dopamine.
Apomorphine directly binds with postsynaptic dopamine receptors.
Contraindications and Cautions
Allergy to dopaminergics. Prevent hypersensitivity reactions
Angle-closure glaucoma. Can be exacerbated by drug effects
Lactation. Can enter breast milk and cause adverse effects to the baby
Pregnancy. Can enter
Suspicious skin lesions. Levodopa is associated with development of melanoma
CV disease, bronchial asthma, psychiatric disorders. Can be exacerbated by dopamine receptor stimulation
Hepatorenal diseases. Can interfere with metabolism and excretion of drug
Apomorphine can increase risk of hypotension and prolonged QT interval.
Adverse Effects
CNS: anxiety, nervousness, headache, malaise, fatigue, confusion, mental changes, blurred vision, muscle
twitching, and ataxia
CV: arrhythmias, hypotension, palpitation
Respiratory: bizarre breathing patterns
GI: anorexia, nausea, vomiting, dysphagia, constipation or diarrhea
GU: urinary retention
Others: flushing, increased sweating, hot flashes
Interactions
MAOI: Increased therapeutic effects and risk of hypertensive crisis. MAOI should be stopped 14 days before
beginning dopaminergic therapy.
Vitamin B6, phenytoin: decreased levodopa efficacy
Over-the-counter vitamins: decreased dopaminergic effectiveness
Implementation with Rationale
These are vital nursing interventions done in patients who are taking dopaminergics:
Decrease dose of drug as ordered if therapy has been interrupted to prevent systemic dopaminergic effects.
Evaluate disease progress and signs and symptoms periodically for reference of disease progress and drug
response.
Give drug with meals to alleviate GI irritation if present.
Monitor bowel function and institute bowel program if constipation is severe.
Have patient void before taking the drugs to decrease risk of urinary retention.
Monitor laboratory test results (renal and liver function, CBC) to detect early signs of dysfunction.
Provide comfort measures to help patient tolerate drug effects.
Provide safety measures (e.g. adequate lighting, raised side rails, etc.) to prevent injuries.
Educate client on drug therapy to promote understanding and compliance.
Anticholinergic Agents : are synthetic drugs which have been developed to achieve a greater affinity for cholinergic
receptor sites in the CNS.Drugs that inhibit the effects of acetylcholine at receptor sites of substantia nigra and corpus
striatum.
AHLZEIMER’S DISEASE
Alzheimer’s disease (AD) is a progressive and irreversible, degenerative, fatal disease and is the most common form of
dementia among older people.
Nursing Interventions
The nursing interventions for a dementia client are:
Orient client. Frequently orient client to reality and surroundings. Allow client to have familiar objects around him
or her; use other items, such as a clock, a calendar, and daily schedules, to assist in maintaining reality
orientation.
Encourage caregivers about patient reorientation. Teach prospective caregivers how to orient client to time,
person, place, and circumstances, as required. These caregivers will be responsible for client safety after
discharge from the hospital.
Enforce with positive feedback. Give positive feedback when thinking and behavior are appropriate, or when
client verbalizes that certain ideas expressed are not based in reality. Positive feedback increases self-esteem
and enhances desire to repeat appropriate behavior.
Explain simply. Use simple explanations and face-to-face interaction when communicating with client. Do not
shout message into client’s ear. Speaking slowly and in a face-to-face position is most effective when
communicating with an elderly individual experiencing a hearing loss.
Discourage suspiciousness of others. Express reasonable doubt if client relays suspicious beliefs in response
to delusional thinking. Discuss with the client the potential personal negative effects of continued suspiciousness
of others.
Avoid cultivation of false ideas. Do not permit rumination of false ideas. When this begins, talk to client about
real people and real events.
o Observe client closely. Close observation of client’s behavior is indicated if delusional thinking reveals an
intention for violence. Client safety is a nursing priority.
Multiple Choice
1. A client with myasthenia gravis has become frequently complaining of weakness and fatigue. The physician plans to
identify whether the client is responding to an overdose of the medication or a worsening of the disease. A tensilon test
is performed. Which of the following would indicate that the client is experiencing an overdose of the medication?
A. Temporarily worsening of the condition.
B. Improvement of the weakness and fatigue.
C. No change in the condition.
D. Complaints of muscle spasms.
ANSWER: ________
RATIO:___________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
2. The diagnostic work-up of a client hospitalized with complaints of progressive weakness and fatigue confirms a
diagnosis of myasthenia gravis. The medication used to treat myasthenia gravis is:
A. Prostigmine (neostigmine)
B. Atropine (atropine sulfate)
C. Didronel (etidronate)
D. Tensilon (edrophonium)
ANSWER: ________
RATIO:___________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
3. Karina a client with myasthenia gravis is to receive immunosuppressive therapy. The nurse understands that this
therapy is effective because it:
A. Promotes the removal of antibodies that impair the transmission of impulses
B. Stimulates the production of acetylcholine at the neuromuscular junction.
C. Decreases the production of autoantibodies that attack the acetylcholine receptors.
D. Inhibits the breakdown of acetylcholine at the neuromuscular junction.
ANSWER: ________
RATIO:___________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
4. Myasthenia gravis is due to ____ receptors being blocked and destroyed by antibodies.
A. Epinephrine
B. Nicotinic
C. Acetylcholine
D. Transient
ANSWER: ________
RATIO:___________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
5. A client with myasthenia gravis has been receiving Neostigmine (Prostigmin). This drug acts by:
A. Stimulating the cerebral cortex
B. Blocking the action of cholinesterase
C. Replacing deficient neurotransmitters
D. Accelerating transmission along neural swaths
ANSWER: ________
RATIO:___________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
7. In making a diagnosis of myasthenia gravis Edrophonium HCI (Tensilon) is used. The nurse knows that this drug will
cause a temporary increase in:
A. Muscle strength
B. Symptoms
C. Blood pressure
D. Consciousness
ANSWER: ________
RATIO:___________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
8. A nurse is instructing a client regarding Carbidopa-levodopa (Sinemet) for the treatment of Parkinson’s disease. The
nurse tells the client that which of the following is a side effect of the medication?
A. Difficulty performing a voluntary movement.
B. Increased blood pressure.
C. Increased heart rate.
D. Itchiness of the skin.
ANSWER: ________
RATIO:___________________________________________________________________________________________
_________________________________________________________________________________________________
______________________________________________________________________________________________
9. A nurse is giving dietary instructions to a client receiving levodopa. Which of the following food items should be avoided
by the client?
A. Goat yogurt.
B. Whole grain cereal.
C. Asparagus.
D. Apples
ANSWER: ________
RATIO:___________________________________________________________________________________________
_________________________________________________________________________________________________
______________________________________________________________________________________________
10. Biperiden hydrochloride (Akineton) is added to a list of antiparkinsonian medications that an elderly client is taking.
Which of the following instructions made by the nurse that needs further learning?
A. To avoid smoking, alcohol and caffeine.
B. To use ice chips, candy or gum for dry mouth.
C. Walking in the morning to have a daily source of direct sunlight.
D. Eating foods rich in fiber and increase fluid intake.
ANSWER: ________
RATIO:___________________________________________________________________________________________
_________________________________________________________________________________________________
______________________________________________________________________________________________
15. A construction worker for 10 years is about to receive anticholinergics. What should the nurse consider in handling this
patient?
A. Do not give the drug to the patient.
B. Administer it with caution.
C. Discuss it with the doctor and have the order changed.
D. Arrange for a possible increase in the dose.
ANSWER: ________
RATIO:___________________________________________________________________________________________
_________________________________________________________________________________________________
______________________________________________________________________________________________
RATIONALIZATION ACTIVITY (THIS WILL BE DONE DURING THE FACE TO FACE INTERACTION)
The instructor will now rationalize the answers to the students. You can now ask questions and debate among yourselves.
Write the correct answer and correct/additional ratio in the space provided.
1. ANSWER: ________
RATIO:_______________________________________________________________________________________
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2. ANSWER: ________
RATIO:_______________________________________________________________________________________
_____________________________________________________________________________________________
_____________________________________________________________________________________________
3. ANSWER: ________
You will now mark (encircle) the session you have finished today in the tracker below. This is simply a visual to help you
track how much work you have accomplished and how much work there is left to do.
You are done with the session! Let’s track your progress.
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