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DZ/Diagnostic

Syndrome*:Pharyn

Mechanism
s

Epidemiolog
y

Time

Reactive
and
postinfectio
us arthritis

most
frequently in
school-age
children. GAS
accounts for
15 to 30 % of
all cases of
pharyngitis in
children :5 -15
yo

Acute
presentation

90 to 95
percent of
adults are
EBVseropositive
majority of 1ry
EBV infections
throughout
the world are
subclinical

EBV has a
latency phase

-Risk
factors ,
including
sexual activity
& injection
drug. -high
suspicion level
.

Within six-month
period following
HIV acquisition,
usually
asymptomatic.
Acute non
specific Sx that
resolves
spontaniously

Symptoms

Signs

Dx Tests

Prognosis

gitis

Group A Beta
Hemolytic Strep

infection

Infectious
Mononucleosis

EBV and
CMV
account for
the
majority of
cases

infection
Mononucleosis
-like
syndrome

Acute Retroviral
Syndrome

Treatment/

When presents
it is usually
Acute
.symptoms
resolve in one to
two weeks, but
fatigue often
persists for
months.

Pharyngitis,
Symptoms
associated
with viral
URT
infections

begins with
malaise,
headache,
and lowgrade fever
Pharyngitis
Rash
associated
with betalactams

Nonspecific
,but
prolonged
duration of
symptoms &
the presence
of
mucocutan
eous ulcers

fever 101103F ,
Anterior
cervical LN :
tender,
enlarged
>1cm.

Rapid strep
test (RST),

glandular
fever HIGH
fever, LAD is
symmetric and
involves the
posterior
cervical chain
more than the
anterior chai

-peripheral
blood smear

Fever, LAD :

Heterophilenegative
Mono like $,
Antibodies:
ELISA/Western
plot,

Nontender
diffuse , sore
throat,rash, my
algia/arthralgia,
and headache|
mucocutaneou
s ulcers

-Throat
CULTURE
before Tx is
initiated.
In absence of
signs and
symptoms of
viral* infections,

- Antibody
studies:
Heterophile
antibodies,
ELISA

HIV RNA
detection
CD4 count

Penicillin v within 9
days of the
infection . good
prognosis unless
complicated : eg
PSGN, Rheumatic
fever ,..

- supportive therapy
Symptomatic
treatment
And Avoiding splenic
rupture (2-21 days
after onset of
symptoms) - Most
acute symptoms
resolve in 1-2 weeks.
Small % chronic
fatigue $ - also EBV
associated with
Hodgkin Lymphoma

potential benefits of
earlier ART outweigh
the potential risks of
increased exposure
to the toxicity of ART

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