Cross Family Comparative Proteomic Study and Molecular Phylogeny of

Cytotoxins in Bacteria
Tasniha Sultana1, Khairun Nesa1, Mohaiminul Islam1, Mohuya Mazumder1, Raju Dash1, Talha
Bin Emran1,2 and Mir Muhammad Nasir Uddin3*
1

Department of Pharmacy, BGC Trust University Bangladesh, Chittagong-4000, Bangladesh

Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong-

4331, Bangladesh
3

Department of Pharmacy, University of Chittagong, Chittagong-4331, Bangladesh

Corresponding Author:
*Mir Muhammad Nasir Uddin
Assistant Professor, Department of Pharmacy
Faculty of Biological Science
University of Chittagong
Chittagong-4331, Bangladesh
Tel: +88-031-726311-14, Ext.4486; Phone: +8801712725987.
E-mail: nasirmir@cu.ac.bd

ABSTRACT
Many pathogenic microorganisms produce protein toxins to survive in the hostile
environments defined by the hosts defense systems and immune response. These toxins can
be highly potent, but they were all initially characterized as cytotoxins because they kill
eukaryotic target cells or at least induce extensive changes in cell morphology. During the
past decade, however, the precise cellular targets of many cytotoxins have been identified,
and their modes of action at a cellular level are now better understood. They constitute
functionally significant family of proteins that is involved in disrupting various cellular
functions like response to mitogens, osmotic stress, heat shock and proinflammatory
cytokines as well as known to play key role in proliferation, gene expression, differentiation,
mitosis, cell survival, and apoptosis. In this study, 45 cytotoxins sequences from various
bacterial species were selected in order to compare their conserved regions, amino acid
composition, evolutionary orders and other statistical parameters.
Key words: Cytotoxins, comparative genomics, and molecular phylogeny.