CURRICULUM VITAE

Pradip Sen

Address: Division of Cell Biology and Immunology, Telephone: +91-172-6665276

CSIR-Institute of Microbial Technology, Fax: +91-172-2690585
Sector-39A email: psen@imtech.res.in
Chandigarh-160036,
India.
Date of Birth: 5-October-1968 Nationality: Indian

Research Career:
Senior Principal Scientist, CSIR-Institute of Microbial Technology 2018-present

Current research activities include understanding the molecular mechanism involved in

immunoregulation of dendritic cells in the context of tumor immunobiology and visceral
leishmaniasis.

Principal Scientist, CSIR-Institute of Microbial Technology 2013-2018

Senior Scientist, CSIR-Institute of Microbial Technology 2009-2013
Scientist, CSIR-Institute of Microbial Technology 2005-2009

Post-Doctoral Research Fellow, University of North Carolina 2000-2005

at Chapel Hill, USA; Worked under Professor Roland Tisch
on immunoregulation of dendritic cells and macrophages
in the context of type-1 diabetes.
Visiting Scientist, Medical Faculty Charite, Humboldt 2000
University, Berlin, Germany.
Ph.D (Science), Indian Institute of Chemical Biology. Kolkata. 1994-1999
Thesis was submitted to Jadavpur University, Kolkata, India.
Degree was awarded in the year 2000.
Thesis title “Role of T cell and macrophage derived chemokines
in Leishmania donovani infection.”

Academic
M.Sc. (Biotechnology), Madurai Kamaraj University, India. 1992-1994
B.Sc. (Ag) Hons., Bidhanchandra Krishi Viswavidyalaya, India. 1987-1992

Awards and Fellowships

Senior Research Fellowship, CSIR, Govt. of India. 1996-1999
Junior Research Fellowship, CSIR, Govt. of India. 1994-1996
Junior Fellow Scholarship for Genetics & Plant Breeding, ICAR, 1992-1994
Govt. of India.
National Merit Scholarship, Govt. of India. 1985-1992
Received merit certificate from Amersham and Science Magazine 2002
for high standard of work based on Ph.D thesis.

Publications:
25 referred articles (selected/recent publications are attached), 2116 citations
Research Grants: Cumulative Career Total ~Rs. 25M
Current Active Grants
2019 - 2022 SERB, DST (Govt. of India)- Regulation of C-type lectin receptor-2 expression in
dendritic cells by Leishmania donovani. ~INR.4100K
2018 - 2022 GCRF, UK- Immunoregulation of dendritic cells by miltefosine-resistant and
miltefosine-sensitive Leishmania parasites (Pump priming). GBP 10000
2019 – 2022 GCRF, UK- Defining the role of a novel receptor in Leishmania infection and
immunoregulation of dendritic cells (POC). GBP 10000
 2021-2022 GCRF, UK- Emerging role of TIM-3 as a new immunoregulator of dendritic cells during
Leishmania donovani infection (POC Ex). GBP 10946.4

Previous Extramural Grants

S. Title Cost in Lakh Duration Role as Agency

No. PI/Co-PI
1 Defining the regulatory role for Rs. 68.254 June 29, PI Department of
RunX proteins in CD40 gene lakhs 2011-June Biotechnology
expression and its impact on 28, 2014 (DBT),
murine dendritic cell activation. Government of
(Sanction Number: India
BT/PR13553/BRB/10/771/2010)
2 Determining the molecular Rs. 46.77 May 13, PI Department of
basis for TIM-3-mediated lakhs 2014- May Biotechnology
immunoregulation of dendritic 12, 2017 (DBT),
cells. Government of
(Sanction Number: India
BT/PR3786/BRB/10/984
/2011)
3 Regulation of innate immune Rs. 28.6 May 30, PI SERB-
responses by Leishmania lakhs 2014- May Department of
donovani via the T cell 29, 2017 Science and
immunoglobulin and mucin Technology,
protein-3 Govt. of India
(Sanction Number: SB/SO/BB-
0076/2013)

Refereeing
 Grant Reviewer for DBT, SERB and CSIR, Govt. of India
 Journal reviewer for Plos Pathogens, Plos One, Frontiers, International Journal of
Biochemistry and Cell Biology, Experimental Parasitology (ELSEVIER publications) and
American Journal of Pathology (ELSEVIER publications), Journal of Neuroimmunology,
Gene Reports etc.

Editorial Boar member

 Frontiers in Drug Discovery
 Frontiers in Immunology
 Microbiology Spectrum
Research activities
My group has made very significant contributions in the area of kala-azar and cancer
research. During 1994-2004, WHO was deeply concerned about large-scale treatment
failure of anti-kala-azar drug sodium antimony gluconate (SAG)
(www.who.int/tdr;TDR/SWG/04). Our pioneering work provided immunological basis for this
SAG-unresponsiveness of kala-azar patients by showing that antimony-resistant
Leishmania donovani attenuates anti-leishmanial efficacy of SAG by inhibiting dendritic
cells (DCs) (PLOS PATHOGENS-2010). Another key invention from my laboratory with
direct medical implication is that Runx proteins promote anti-leishmanial immunity by
enhancing CD40-mediated type-1 T-cell responses (PLOS PATHOGENS-2020). This
study is equally significant for other pathogenic infections and has been featured by the
British Society for Parasitology (https://plos.altmetric.com/details/96796194/twitter). My lab
has also made seminal contributions in cancer biology. Our work revealed c-Src as
important target to reduce TIM-3 receptor’s expression on DCs and augment anti-tumor
immunity (J Biol Chem-2011, J Immunol-2014, J Immunol-2016). Notably, TIM-3 is an
emerging “check-point” receptor in cancer. Our work on TIM-3 was acclaimed as
outstanding by Prof. Vijay Kuchroo (Harvard Medical School), who discovered TIM-3.
Indeed, our study showing TIM-3 as inhibitory receptor on DCs (J Immunol-2014) has
overturned the prevailing paradigm that TIM-3 drives DC activation. Our another work on
c-Src and c-MET (Int J Biochem Cell Biol-2011) prompted the researchers of MD
 Anderson Cancer Center to conduct first human Phase-I trial for evaluating anti-cancer
efficacy of crizotinib and dasatinib (Invest New Drugs-2018;doi:10.1007/s10637-017-0513-
5). Thus, my group’s work has unveiled many unique mechanisms and potential
therapeutic targets to combat kala-azar and cancer.

Beside fundamental research, my group at CSIR-IMTECH has successfully developed the

biosimilar of adalimumab, which is world’s top selling drug and used for treatment of
rheumatoid arthritis. Because adalimumab-based therapy is largely unaffordable by many
Indian patients, our work has tremendous societal significance.

List of publications:

S. Author(s) Title Name of Volu Page Year

No. Journal me
1 Md. Naushad Leishmania donovani mBio In 2022
Akhtar, Sahil impedes antileishmanial press
Kumar, and Pradip immunity by suppressing
Sen dendritic cells via the
TIM-3 receptor
2. Prateek Singh, ---- A machine learning- Computers in 146 105419 2022
Pradip Sen, ---- based approach to Biology and
Debasis Dash determine infection Medicine
status in recipients of
BBV152 (Covaxin)
whole-virion inactivated
SARS-CoV-2 vaccine for
serological surveys
3 S Naushin,--- Insights from a Pan India Elife 10 e66537 2021
Pradip Sen,--- and Sero-Epidemiological
Shantanu survey (Phenome-India
Sengupta Cohort) for SARS-CoV2
4 Md. Naushad Runx proteins mediate PLOS 16(1 e1009136. 2020
Akhtar, Manish protective immunity PATHOGENS 2)
Mishra, Vinod against Leishmania
Yadav, Manisha donovani infection by
Yadav, Ravindra promoting CD40
Gujar, Sunaina Lal, expression on dendritic
Raj Kumar, Neeraj cells.
Khatri and Pradip
Sen.
5 Ravindra Gujar, Transforming growth Cytokine In 2018
and Pradip Sen factor-1 impairs lymph press
node homing of dendritic
cells by downregulating
C-type lectin receptor-2
expression
6 Prateek Srivastava, Protease-Responsive ACS 3 3376−3385 2017
Sumit Kumar Hira, Targeted Delivery of Biomaterials
Divesh Narayan Doxorubicin from Science &
Srivastava, Uttam Bilirubin-BSA-Capped Engineering
Gupta, Pradip Sen, Mesoporous Silica
Ram Adhar Singh, Nanoparticles against
and Partha Pratim Colon Cancer
Manna
7 Ravindra Gujar, c-Src suppresses Journal of 197 1650-1662. 2016
Neeraj Maurya, dendritic cell antitumor Immunology
Vinod Yadav, activity via T cell Ig and
Mamta Gupta, mucin protein-3
Saurabh Arora, receptor.
Neeraj Khatri and
Pradip Sen
8 Neeraj Maurya, Immunoregulation of Journal of 193 3417-3425 2014
Ravindra Gujar, Dendritic Cells by the Immunology
Mamta Gupta, Receptor T cell Ig and
Vinod Yadav, Mucin Protein-3 via
Saurabh Verma Bruton's Tyrosine
and Pradip Sen Kinase and c-Src
9 Eshu Singhal, A novel role for Bruton’s Journal of 286 32054- 2011
Prakash Kumar tyrosine kinase in Biological 32063
and Pradip Sen hepatocyte growth Chemistry
factor-mediated
immunoregulation of
dendritic cells
10 Eshu Singhal and Hepatocyte growth The 43 1134-1146 2011
Pradip Sen factor-induced c-Src- International
phosphatidylinositol 3- Journal of
kinase-AKT-mammalian Biochemistry
target of rapamycin and Cell Biology
pathway inhibits
dendritic cell activation
by blocking IB kinase
activity
11 Arun Kumar Use of antimony in the Molecular Articl 2011
Haldar, Pradip treatment of Biology e
Sen, and Syamal leishmaniasis: current International ID
Roy. status and 5712
future directions. 42
(3),
Volu
me
2011
12 Arun Kumar Leishmania donovani PLoS 6 e1000907 2010
Haldar, Vinod isolates with antimony- Pathogens
Yadav, Eshu resistant but not -
Singhal, Kamlesh sensitive phenotype
Kumar Bisht, inhibit sodium antimony
Alpana Singh, gluconate-induced
Suniti Bhaumik, dendritic cell activation.
Rajatava Basu,
*
Pradip Sen and
Syamal Roy
*
( Corresponding
author).
13 Mark A. Wallet, MerTK is required for Journal of 205 219-232 2008
Pradip Sen, Rafael apoptotic cell-induced T Experimental
R. Flores, Yaming cell tolerance. Medicine
Wang, Zuoan Yi,
Yingsu Huang,
Clayton E.
Mathews , H.
Shelton Earp,
Glenn Matsushima,
Bo Wang and
Roland Tisch
14 Pradip Sen, Mark Apoptotic cells induce Blood 109 653-660 2007
A Wallet, Michael Mer tyrosine kinase-
Henderson, dependent blockade of
Clayton E NF-B activation in
Mathews, H. dendritic cells
Shelton Earp,
Glenn Matsushima,
Albert Baldwin,
Roland Tisch
15 Debobani Human placental extract Annals of 101 1-18 2007
 Chakraborty, Jyoti offers protection against Tropical
M. Basu, Pradip experimental visceral Medicine and
Sen, Shyam leishmaniasis: a pilot Parasitology
Sundar and Syamal study for a phase-I
Roy clinical trial.
16 Jayati Mookerjee Sodium antimony Antimicrobial 50 1788-1797 2006
Basu, Ananda gluconate induces Agents and
Mookerjee, generation of reactive Chemotherapy
Prosenjit Sen, oxygen species and
Suniti Bhaumik, nitric oxide via
Pradip Sen, Subha Phosphoinositide 3
Banerjee, Kinase and Mitogen-
Khudiram Naskar, Activated Protein Kinase
Soumitra K. activation in Leishmania
Choudhuri, donovani-infected
Bhaskar Saha, macrophages.
Sanghamitra Raha
and Syamal Roy
17 Hongsheng Wang, EBV Latent Membrane Journal of 177 2793-2802 2006
Matilda W. Protein 2A Induces Immunology
Nicholas, Kara L. Autoreactive B Cell
Conway, Pradip Activation and TLR
Sen, Ramiro Diz, Hypersensitivity
Roland M. Tisch
and Stephen H.
Clarke
18 Kaushik Evidence of direct Molecular and 150 374-377 2006
Roychoudhury, interactions between the Biochemical
Biplab Dasgupta, CC-chemokines CCL3, Parasitology
Pradip Sen, CCL4 and CCL5 and
Tamas Laskay, Leishmania
Werner Solbach, promastigotes
Tripti De and
Syamal Roy
19 Mark A Wallet, Immunoregulation of Clinical 3 166-175 2005
Pradip Sen and dendritic cells. Clinical Medicine and
Roland Tisch Medicine and Research Research
20 Sandip Immunoregulation of Blood 104 1100-1109 2004
Bhattacharyya, dendritic cells by IL-10 is
Pradip Sen, Brian mediated through
Long, Mark Wallet, suppression of the
Albert S. Baldwin, PI3K/Akt pathway and of
Jr., and Roland IB kinase activity.
Tisch
21 Pradip Sen, NF-B hyperactivation Journal of 170 1770-1780 2003
Sandip has differential effects Immunology
Bhattacharyya, on the APC function of
Mark Wallet, nonobese diabetic
Carmen P. Wong, mouse macrophages.
Brian Poligone,
Maitreyee Sen,
Albert S. Baldwin
and Roland Tisch
22 Brian Poligone, Elevated NF-B Journal of 168 188-196 2002
Donald J. Weaver, activation in nonobese Immunology
Jr., Pradip Sen, diabetic mouse dendritic
Albert S. Baldwin, cells results in enhanced
Jr. and Roland APC function.
Tisch
23 Sandip Selective impairment of Molecular and 216 47-57 2001
Bhattacharyya, protein kinase C isotype Cellular
Sanjukta Ghosh, in murine macrophage Biochemistry
Pradip Sen, by Leishmania donovani.
 Syamal Roy and
Subrata Majumdar
24 Srirupa Immunoprophylaxis and Vaccine. 17 291-300 1999
Mukhopadhyay, immunotherapy against
Pradip Sen, experimental visceral
Sandip leishmaniasis.
Bhattacharyya,
Subrata Majumdar
and Syamal Roy
25 Srirupa Reduced expression of Journal of 84 644-647 1998
Mukhopadhyay, lipophosphoglycan Parasitology.
Pradip Sen, (LPG) and kinetoplastid
Hemanta K. membrane protein
Majumder and (KMP)-11 in Leishmania
Syamal Roy donovani promastigotes
in axenic culture.