1/6/2015

WhatareStreptomycetes?

PICTURES OF STREPTOMYCETES

ANTIBIOTICS PRODUCED BY STREPTOMYCETES

SomeexamplesproducedbyStreptomycetesandtherelatedactinomycetesaredescribed
asbelow.Representedasantimicrobialcompoundagainsttuberculosisarestreptomycin
(Streptomycesgriseus),rifamycin(Amycolatopsismediterranei),erythromycin
(Saccharopolysporaerythraea),andoleandomycin(Streptomycesantibioticus).Thereare
morebioactivecompoundssuchasavermectin(Streptomycesavermitilis),bleomycin
(Streptomycesverticillus)anddaunomycin(Streptomycespeuceticus)asantitumor
compounds,FK506(Streptomycestsukubaensis)asanimmunosuppressant,and
validamycin(Stereptomyceshygroscopicusvar.limoneus)asatreatmentofricesheath
blightdisease.

COMPLEX LIFE CYCLE OF STREPTOMYCES

Asporegerminateswithspreadingthefilamentsintosuchasolidmedium("vegetative
mycelium",step02).Thenthedevelopedvegetativemyceliumformsporophoresvertically
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1/6/2015

WhatareStreptomycetes?

towardthesurface("aerialmycelium",step34).Theaerialmyceliumspirals(step5),and
thenthepolynycleatedaerialfilamentsarepartitioned(step6).Theresultingsheathswill
becomespores(step7),andtheanothercyclecontinues.Thesecondarymetabolites
includingantibioticsaresecretedduringthegenerationofaerialhyphaefromthevegetative
mycelium.

[gotolab'smainpage]

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