Punnett Genetic Counseling

450 MacGahan Street

Huntington, IN 46750
260-354-9971

Client Name: Tom and Jill

Pedigree

I.

AA or
Aa

II.

aa

Aa

Aa

aa

6
AA or
Aa

Aa

aa

Aa

AA

AA

Aa

Aa

III.

Aa

Aa

1 aa

Aa

Aa

IIII.

AA

AA or
Aa

AA or
Aa

Aa

AA or
Aa

AA or
Aa

aa

Punnett Squares
A

Case 1: Affected 0% Unaffected 100%

Case 2: Affected 25% Unaffected 75%
Genetic Disorder: Sickle Cell Disease
Sickle-cell disease (SCD), also known as sickle-cell anemia (SCA) is a
hereditary blood disorder, characterized by an abnormality in the oxygencarrying hemoglobin molecule in red blood cells. Sickle-cell disease is

associated with a number of acute and chronic health problems, such as

severe infections, attacks of severe pain ("sickle-cell crisis"), and stroke, and
there is an increased risk of death.

Others with Sickle-Cell Disease

Atiim Kiambu "Tiki" Barber is a former NFL running back that has Sickle-cell
disease. This disorder, while it can cause apprehensive difficulties, did not stop him
from playing in the NFL.

Conclusion:
If Jill is not a carrier, then there is no risk for any of Tom and Jills offspring to
get Sickle-cell disease. If Jill is a carrier for the disease, then there is only a
25% chance of any of their offspring getting Sickle-cell disease.