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    LIMFOGRANULOMA VENEREUM (LGV) is a sexually transmitted disease characterized by inguinal lymphadenitis and periadenitis, caused by Chlamydia trachomatis serotypes L1-L3. Symptoms include primary genital lesions that appear 4 weeks after exposure, followed by unilateral or bilateral swelling of the inguinal lymph nodes 3-8 weeks later. Without treatment, LGV can cause genital elephantiasis, anal strictures, or urethral swelling. Diagnosis involves clinical features, elevated white blood cells and IgA, culture or PCR of lesions, and Frei's test. Treatment consists of doxycycline, erythromycin

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    LIMFOGRANULOMA VENEREUM (LGV) is a sexually transmitted disease characterized by inguinal lymphadenitis and periadenitis, caused by Chlamydia trachomatis serotypes L1-L3. Symptoms include primary genital lesions that appear 4 weeks after exposure, followed by unilateral or bilateral swelling of the inguinal lymph nodes 3-8 weeks later. Without treatment, LGV can cause genital elephantiasis, anal strictures, or urethral swelling. Diagnosis involves clinical features, elevated white blood cells and IgA, culture or PCR of lesions, and Frei's test. Treatment consists of doxycycline, erythromycin

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    13 views13 pages

    IGV by Wahyu

    Uploaded by

    chandrahidayat
    LIMFOGRANULOMA VENEREUM (LGV) is a sexually transmitted disease characterized by inguinal lymphadenitis and periadenitis, caused by Chlamydia trachomatis serotypes L1-L3. Symptoms include primary genital lesions that appear 4 weeks after exposure, followed by unilateral or bilateral swelling of the inguinal lymph nodes 3-8 weeks later. Without treatment, LGV can cause genital elephantiasis, anal strictures, or urethral swelling. Diagnosis involves clinical features, elevated white blood cells and IgA, culture or PCR of lesions, and Frei's test. Treatment consists of doxycycline, erythromycin

    Copyright:

    © All Rights Reserved
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    of 13

    LIMFOGRANULOMA

    VENEREUM
    (L.G.V)

    Sinonim

    Limfopathia venereum (L.V)


    Penyakit Nicholas Faure
    Penyakit Frei
    Climatic Bubo ; Tropical Bubo

    Definisi
    Penyakit kelamin yang khas ditandai dengan
    limfadenitis dan periadenitis inguinal yang
    unilateral/ bilateral

    Epidemiologi
    Tropis/ subtropis
    Indonesia musim hujan >>
    >

    Etiologi
    Chlamydia trachomatis
    Serotype L1, L2, L3

    Simtomatologi
    4 minggu
    DINI
    Primer afek - erosi
    (sepintas) - papel
    - vesikel pustel
    - ulkus
    - genitalia luar
    - serviks & ddg belakang
    vagina

    Simtomatologi
    DINI
    Sindrom inguinal : 3 8 minggu
    Limfadenitis
    unilateral
    Periadenitis
    KGB inguinal medial, bisa membesar ke iliaca (dalam) atau
    femoral (luar)
    Abses multilokular
    Fistel & sinus multipel (darah, nanah)
    Resolusi parut
    Sign of the Groove
    Etage bubonen
    Gejala konstitusi
    KGB gerota membesar pem. bimanual
    KGB inguinal -

    Simtomatologi
    Lanjut
    Sindroma Genital
    Elefantiasis genital (Esthiomene) o.k bendungan menahun
    limfe
    labium mayor/ minor; klitoris
    skrotum
    Sindroma Genito-anorektal
    = Sindroma Jersild: genital >> + ulkus dan strictura recti
    Sindroma Anorektal
    homosex
    portio/ atas vagina

    Darah, pus

    Simtomatologi
    Lanjut

    Sindroma Uretral
    Lesi intra uretral sekret OUE mulut ikan
    Penis Pedang Turki
    Keganasan

    Pemeriksaan Pembantu
    Diagnosis
    1.

    Lab
    Lekosit N
    LED
    Ig A

    2. Kultur
    Aspirasi pus

    Pemeriksaan Pembantu
    Diagnosis
    3. Tes Frei
    pasteurisasi

    a. Pus + grm faal


    intra dermal
    bertingkat
    (LGV)
    Lygranum
    stlh 48 jam : eritema > 5 mm
    seumur hidup
    b.

    Pus
    (suspect)

    suntik

    org pernah LGV

    4. Tes Fiksasi Komplemen (Complement Fixation Test)


    5. Tes Mikro-imunofloresensi (Micro-IF)
    Sensitif dapat bedakan serotipe LGV. L1, L2, L3

    DD/ :
    1. Ulkus mole
    2. Skrofuloderma

    Diagnosis :
    Anamnesa

    3. Limfadenitis
    piogenik
    4. Limfoma maligna

    Gejala klinik

    5. Hernia
    inkarserata
    6. Primer kompleks
    sifilis

    Tes Frei

    Lab rutin & Ig A

    Therapy
    1.
    2.

    3.
    4.
    5.

    Gol. Sulfonamida
    Trisulfa 3 4 x 1 g/ 10 hari
    Co-Trimoxazole (Bactrim, Septrin)
    Trimetoprim
    3 x 2 tab/ 10 20 hr
    Sulfometoksasol
    Tetrasiklin !
    4 x 500 mg/ 10 20 hr
    Eritromisin
    Kloramfenikol 4 x 500 mg/ 14 hr
    Aspirasi atau insisi abses

    MANAGEMENT
    ( Th.B. Fitzpatrick )
    Prevention: Condom use
    Antimicrobial Therapy:
    To cures infection & tissue damage, aspirationdrainage Buboes intact skin
    * Doxycycline, 100 mg PO bid 21 days
    * Erythromycin, 500 mg PO qid 21 days
    * Sulfisoxazole, 500 mg PO qid 21 days
    Follow-Up: Clinically until signs/symptoms resolved
    Management Sex Partners:
    Evaluation & treatment

    Prognosis
    Therapy dini
    Obat adekuat

    Baik

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