Learning Objectives for Lecture 22 Immunopathology of infections

1. Compare the functional differences between the innate versus the adaptive immune
response.
2. Contrast the primary versus the secondary immune responses to microbes.
3. Explain the dual nature of the integrated immune system.
4. Apply the basic concepts of the immune response as they relate to immune mediation of
disease.
5. Describe the role of CD4+ and CD8+ T cells in the adaptive immune response to viral
infection.
6. Describe the role of CD4+ T cells in activation of macrophages.
7. Describe the mechanism of damage to the host that may occur from virus -antibody
immune complexes.
8. Describe the mechanism of damage to the host that may occur from the cell -mediated
response to a virus.
9. List the four types of hypersensitivity reactions and give examples of their involvement in
host damage in infections.
10. Describe the delayed type hypersensitivity as it relates to host responses against
intracellular bacteria.
11. Identify the type of immune response that is involved in the development of lesions
characteristic of tuberculosis due to Mycobacterium tuberculosis
12. Describe the process that results in damage that may occur as an autoimmune sequelae
of an infection.
13. Outline the consequences of complement deficiencies and give examples of associated
diseases for each.