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BIOEN 5301/ To Modern Biomaterials: January 14, 2004
BIOEN 5301/ To Modern Biomaterials: January 14, 2004
6900: Introduction
to Modern Biomaterials
January 14, 2004
Lecture 2
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ceramics
metals
polymers, synthetic and natural
composites
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Structure
Synthesis
+processing
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Properties
Physical
Biological
Ceramics
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Ceramics
Advantages:
- inert in body (or bioactive in
body)
- high wear resistance
(orthopedic & dental applications)
- high modulus (stiffness) &
compressive strength
- fine esthetic properties for
dental applications
Disadvantages:
- brittle (low fracture resistance,
flaw tolerance)
- low tensile strength (fibers are
exception)
- poor fatigue resistance (relates
to flaw tolerance)
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Ceramic Applications
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Ceramics
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Metals
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Metals Manufacturing
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Metals
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Medical Tubing
Stents
Catheters
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Polymers
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Polymers
Hydrophilic
Hydrophobic
Biostable
Biodegradable
Natural
Synthetic
Highly
processable
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Composites
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Bioactive Materials
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Applications
Catheters, tubing
Vascular grafts
Intraocular lenses, bone
cement
Polyurethanes
Catheters, pacemaker
leads
Stainless steel
Collagen (reprocessed)
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Requirements of Biomaterials
A biomaterial must be:
inert or specifically interactive
biocompatible
mechanically and chemically stable or
biodegradable
processable (for manufacturability)
nonthrombogenic (if blood-contacting)
sterilizable
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Progress in Healthcare
Technology moves on
from bio-inert & current biocompatible materials with
limited useful life
to second generation, structurally and functionally
advanced materials
to body replacement and augmentation devices
active in a physiological and pathology-correcting
way over an entire life-time
Tissue engineering, microsystems and
nanotechnology will address many of these needs
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