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  • Yasko Methylation Cycle PDF

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    Eric Ehle
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    Homocysteine is metabolized to alpha-ketobutyrate, NH3 and H2S. Glutathione and serotonin are involved in the methylation of adenosine. Glycine and tryptophan are involved in thymidine synthesis.

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    Homocysteine is metabolized to alpha-ketobutyrate, NH3 and H2S. Glutathione and serotonin are involved in the methylation of adenosine. Glycine and tryptophan are involved in thymidine synthesis.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    152 views1 page

    Yasko Methylation Cycle PDF

    Uploaded by

    Eric Ehle
    Homocysteine is metabolized to alpha-ketobutyrate, NH3 and H2S. Glutathione and serotonin are involved in the methylation of adenosine. Glycine and tryptophan are involved in thymidine synthesis.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    glycine

    Thymidine
    synthesis
    Purines
    Methionine

    dUMP

    SHMT
    Tryptophan
    Arginine

    Acetyl CoA

    aspartate

    ACAT

    fumarate

    Krebs
    Cycle

    succinate

    isocitrate

    serine

    glycine

    DMG

    B12

    MTR

    AMMONIA

    OTC

    MTRR

    MTHFR

    BHMT

    CBS

    Microglial
    Activation

    HIAA

    COMT

    AMMONIA

    SAMe

    NorEp

    Cysteine + , -ketobutyrate

    SAH

    HVA
    VMA

    Super Oxide

    SAH

    When the need is for energy and not for


    cysteine, homocysteine is metabolized to
    Alpha-Ketobutyrate, NH3 and H2S.
    Text of Biochemistry with Clinical Correlations, Devlin 2002

    GST

    SUOX

    SOD
    G6PDH
    glutamate

    Content and diagrams may not be reproduced without express permission from NRI

    glutathione

    taurine

    COMT

    Peroxynitrite

    Yasko Methylation Pathway

    cystathionine

    Dopamine

    0 BH4

    Neuronal
    Damage

    1 BH4

    Citrulline + NO

    SAH

    Homocysteine

    VDR
    MAO A

    NADH/FADH

    SAH

    AHCY

    5 Methyl
    THF

    BH2

    Serotonin

    DNA, RNA
    Protein, lipids

    methylation

    adenosine

    LEAD

    -ketoglutarate

    Creatinine

    SAMe

    TMG

    DHPR

    NOS
    UREA

    mercury
    lead

    ALUM

    Ornithine

    citrate

    Creatine

    2 BH4

    oxaloacetate

    Tyrosine

    BH4

    Guanido AC

    THF

    5. 10
    Methylene THF

    Pyruvate

    MAT

    gaba

    GAD

    cortisol

    ACE
    Angiotensin I

    Angiotensin II

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