TRICYCLIC

ANTIDEPRESSANT

BY : RAJIV MENON
141501229

MECHANISM OF ACTION

INHIBITION OF NEUROTRANSMITTER UPTAKE

BLOCKING OF RECEPTOR

INHIBITION OF NEUROTRANSMITTER

TRICYCLIC ANTIDEPRESSANTS ARE POTENT INHIBITORS OF NOREPINEPHRINE

AND SEROTONIN INTO PRESYNAPTIC NERVE TERMINAL

INCREASES CONCENTRATION OF MONOAMINES IN SYNAPTIC CLEFT THAT CAUSES

ANTIDEPRESSANT EFFECTS

HELPS BRAIN CELL SEND AND RECEIVE MESSAGES THAT BOOST MOOD

BLOCKING RECEPTOR

TRICYCLIC ANTIDEPRESSANT BLOCK SEROTONERGIC, ALPHA ADRENERGIC ,

HISTAMINIC AND MUSCARINIC RECEPTORS

THERAPEUTIC USES

USED TO TREAT SEVERE MAJOR DEPRESSION, BIPOLAR DISORDER

IMIPRAMINE USED TO CONTROL BED WETTING IN CHILDREN OLDER THAN 6

YEARS OLD BY CONTRACTING INTERNAL SPHINCTER OF BLADDER

USED AS ANALGESICS

-AMITRIPTYLINE USED TO TREAT CHRONIC PAIN (NEUROPATHIC PAIN)

- TO TREAT MIGRAINE PROPHYLAXIS

SIDE EFFECTS

DESPITE BEING AN IMPORTANT GROUP OF ANTIDEPRESSANT DRUG THEY ARE

NOT IDEAL DUE TO THE THEIR SIDE EFFECTS.
SIDE EFFECTS INCLUDES :

-SEDATION CAUSED BY HISTAMINE H1 RECEPTOR BLOCKAGE

-POSTURAL HYPOTENSION CAUSED BY ADRENORECEPTOR BLOCKAGE
-BLURRED VISION ,DRY MOUTH AND CONSTIPATION DUE TO MUSCARINIC
ACETYLCHOLINE RECEPTOR BLOCKAGE

THANK YOU