• Nine healthy subjects given 20 mg metoclopramide 30

minutes before fosfomycin 50 mg / kg . Then a week later,

cimetidine, 400 mg and 400 mg the previous evening 30
minutes before fosfomycin 50 mg / kg. Cimetidine almost no
effect on the pharmacokinetics of fosfomycin trometamol,
while metoclopramide reduces the peak serum levels by 42%
and AUC by 27%. The reason seems to be that
metoclopramide is to accelerate intestinal transit through, so
less time is available for absorption. However, despite this
reduction, urinary concentration remains above the minimum
level required for common urinary pathogens for at least 36
hours after giving antibacterial. This suggests that these
interactions may be clinically important.
• drug checker Medscape
• Drugs Interaction Facts
• Stockley Drugs Interaction
• Drugs.com
• Pubmed
• Medline
• drug