Carla Coste Snchez

November/23/2015
Homework: PBPK Differential equations
Gi Tract
d C GI Q GI
C
=
C B GI
dt
V GI
K GIp

Spleen
d C S QS
C
= C B S
dt
VS
K Sp

Kidney
d CK QK
CK
CK
=
CB
CL K
dt
VK
K Kp
K Kp

Remainder
d CR QR
C
C
=
C B R CL R R
dt
VR
K Rp
K Rp

Diffusion limited model: Lung and Heart

Cell Compartment
Heart
d C H (CC ) PS H
C H (CC )
=
C H (IS)
dt
VH
K Hp

)(

)(

Legend
GI=GI Tract

H=Heart

S=Spleen
LU =Lung

R=Remainder
Lung
d C LU (CC) PS LU
C LU (CC )
=
C B (IS )
dt
V LU
K LUp

L=Liver
K=Kidneys

B=Blood

C X =Concentration of free drug

the specified tissue

Q X =Blood flow of

the specified tissue

Interstitial Space
Heart
C H (CC)
d C H QH
PS
=
( C B C H (IS ) ) H C H (IS)
dt
VH
VH
K Hp

K PX =Plasmatissue

partitioncoefficient
PSt =Permiationcoefficientsurface area cross

Lung
C LU (CC ) product for a specific tissue
d C LU Q LU
PS LU
=
C C LU ( IS ))
C LU (IS )
dt
V LU ( B
V LU
K LU p CL X =Clearance thetissue

IS=Interstitial Space
Perfusion limited model: Liver, Kidneys and
Remainder
Liver
d CL CB
CGI
= ( Q L QGI Q S ) +
Q
dt
VL
K GIp GI

CC=Cell Compartment

gend:
GI=GI Tract
S=Spleen L=Liver
CS
CL
CL
+
QS H=Heart
Q L CL

L
LU =Lung
K=Kidneys
K Sp
K Lp
K Lp

)(

)(

)(

R=Remainder

B=Bloo