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    Three new guanidine alkaloids, acanthamines A-C, were isolated from the marine sponge Acanthella cavernosa. These alkaloids were found to stabilize the tumor suppressor protein PDCD4 and inhibit the proliferation of cancer cell lines. Acanthamines A-C represent a new class of compounds that may serve as leads for developing anticancer therapeutics targeting the PDCD4 pathway.

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    Three new guanidine alkaloids, acanthamines A-C, were isolated from the marine sponge Acanthella cavernosa. These alkaloids were found to stabilize the tumor suppressor protein PDCD4 and inhibit the proliferation of cancer cell lines. Acanthamines A-C represent a new class of compounds that may serve as leads for developing anticancer therapeutics targeting the PDCD4 pathway.

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    2 views1 page

    By, ,, ,, ,,, and

    Uploaded by

    Yhugho Bng
    Three new guanidine alkaloids, acanthamines A-C, were isolated from the marine sponge Acanthella cavernosa. These alkaloids were found to stabilize the tumor suppressor protein PDCD4 and inhibit the proliferation of cancer cell lines. Acanthamines A-C represent a new class of compounds that may serve as leads for developing anticancer therapeutics targeting the PDCD4 pathway.

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    of 1

    ricyclic Guanidine Alkaloids from the Marine Sponge Acanthella cavernosa that Stabilize the

    Tumor Suppressor PDCD4


    by Tanja Grkovic, Johanna S. Blees, Magdalena M. Bayer, Nancy H. Colburn, Cheryl L.
    Thomas, Curtis J. Henrich, Megan L. Peach,James B. McMahon, Tobias Schmid and Kirk R.
    Gustafson
    Mar. Drugs 2014, 12(8), 4593-4601; doi:10.3390/md12084593
    Received: 4 June 2014 / Revised: 25 June 2014 / Accepted: 24 July 2014 / Published: 21 August
    2014
    Show/Hide Abstract | Cited by 1 | PDF Full-text (589 KB) | HTML Full-text | XML Full-text | Supplementary
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