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    This document summarizes research on new chemical compounds called tricyclic guanidine alkaloids discovered in the marine sponge Acanthella cavernosa. Experiments showed these compounds stabilize the tumor suppressor protein PDCD4, which promotes programmed cell death in cancer cells. The discovery of molecules that stabilize PDCD4 could provide opportunities for developing new anti-cancer therapies.

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    This document summarizes research on new chemical compounds called tricyclic guanidine alkaloids discovered in the marine sponge Acanthella cavernosa. Experiments showed these compounds stabilize the tumor suppressor protein PDCD4, which promotes programmed cell death in cancer cells. The discovery of molecules that stabilize PDCD4 could provide opportunities for developing new anti-cancer therapies.

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    2 views1 page

    By, ,, ,, ,,, and

    Uploaded by

    Yhugho Bng
    This document summarizes research on new chemical compounds called tricyclic guanidine alkaloids discovered in the marine sponge Acanthella cavernosa. Experiments showed these compounds stabilize the tumor suppressor protein PDCD4, which promotes programmed cell death in cancer cells. The discovery of molecules that stabilize PDCD4 could provide opportunities for developing new anti-cancer therapies.

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    Communication: Tricyclic Guanidine Alkaloids from the Marine Sponge Acanthella

    cavernosa that Stabilize the Tumor Suppressor PDCD4


    by Tanja Grkovic, Johanna S. Blees, Magdalena M. Bayer, Nancy H. Colburn, Cheryl L.
    Thomas, Curtis J. Henrich, Megan L. Peach,James B. McMahon, Tobias Schmid and Kirk R.
    Gustafson
    Mar. Drugs 2014, 12(8), 4593-4601; doi:10.3390/md12084593

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