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  • L Asparaginase 2015 02 26 11 58 24 PDF

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    Venkata Suryanarayana Gorle
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    L-Asparaginase is an enzyme produced by E. coli that is used as an anti-tumor agent. It depletes the amino acid L-asparagine, which is important for cancer cell growth. L-asparaginase inhibits the growth of malignant cells and is used to induce remission in acute lymphoblastic leukemia. It works by depriving cancer cells of circulating asparagine, while normal cells can synthesize their own. The product is a lyophilized powder containing L-asparaginase from E. coli with a purity greater than 96% and a molecular mass of 31731 Dalton. It has a two year shelf life when stored at -20°C

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    L-Asparaginase is an enzyme produced by E. coli that is used as an anti-tumor agent. It depletes the amino acid L-asparagine, which is important for cancer cell growth. L-asparaginase inhibits the growth of malignant cells and is used to induce remission in acute lymphoblastic leukemia. It works by depriving cancer cells of circulating asparagine, while normal cells can synthesize their own. The product is a lyophilized powder containing L-asparaginase from E. coli with a purity greater than 96% and a molecular mass of 31731 Dalton. It has a two year shelf life when stored at -20°C

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    14 views2 pages

    L Asparaginase 2015 02 26 11 58 24 PDF

    Uploaded by

    Venkata Suryanarayana Gorle
    L-Asparaginase is an enzyme produced by E. coli that is used as an anti-tumor agent. It depletes the amino acid L-asparagine, which is important for cancer cell growth. L-asparaginase inhibits the growth of malignant cells and is used to induce remission in acute lymphoblastic leukemia. It works by depriving cancer cells of circulating asparagine, while normal cells can synthesize their own. The product is a lyophilized powder containing L-asparaginase from E. coli with a purity greater than 96% and a molecular mass of 31731 Dalton. It has a two year shelf life when stored at -20°C

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 2

    L-Asparaginase

    Product Data Sheet


    Type:
    Source: E. coli
    Species:

    Cat. No.:
    RP17928710000

    (10,000 IU)

    RP1792872500

    (500 IU)

    Description
    L-Asparaginase produced from E.Coli containing 303 amino acids and having a molecular mass of 31731 Dalton.

    Introduction to the Molecule


    L-Asparaginase is an enzyme that depletes L-Asparagine an important nutrient for cancer cells resulting in cancer/tumor cell
    starvation. L-asparaginase is an anti-tumor agent derived from E.coli.,which can inhibit the growth of malignant cells. It is used
    mainly for the induction of remission in acute lymphoblastic leukaemia. Because of the lymph node origin of malignant B cells
    in Multiple Myeloma, L-Asparagine is an essential amino acid for their cell metabolism, and, consequently, L-Asparaginase
    may be of value in managing the disease. The rationale behind asparaginase is that it takes advantage of the fact that ALL
    cellsare unable to synthesize the non-essential amino acidasparagine whereas normal cells are able to make their own
    asparagine. These leukemic cells depend on circulating asparagine. Asparaginase however catalyzes the conversion of Lasparagine to aspartic acid and ammonia. This deprives the leukemic cell of circulating asparagine.

    Source
    E. coli

    Purity
    Greater than 96.0% as determined by:
    (a) Analysis by RP-HPLC.
    (b) Analysis by SDS-PAGE.

    Formulation
    The enzyme was lyophilized with no additives.

    Shipping
    At ambient temperature. Upon receipt, store the product at the temperature recommended below.

    Storage, Stability/Shelf Life


    Two years when stored at -20C, 2 weeks at 4C.

    Physical Appearance
    Sterile Filtered White lyophilized (freeze-dried) powder.

    References to this Product

    Page 1 of 2 (VERSION: 2015-02-27)

    Fernandez CA, Cai X, Elozory A, Liu C, Panetta JC, Jeha S, Molinelli AR, Relling MV. High-throughput asparaginase
    activity assay in serum of children with leukemia. Int J Clin Exp Med. 2013;6 (7):478-87

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    Page 2 of 2 (VERSION: 2015-02-27)

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