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    Angga Eka
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    Osteosarcoma is a malignant bone cancer that arises from primitive bone cells. It is most common in people ages 12-25 and forms a painful bone mass, often in the femur. Risk factors include radiation exposure and surviving other cancers like retinoblastoma. Diagnosis involves clinical exams, radiology like X-rays showing lytic or sclerotic lesions, and biopsy showing malignant osteoid and spindle cells. Early metastasis is common.

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    Osteosarcoma is a malignant bone cancer that arises from primitive bone cells. It is most common in people ages 12-25 and forms a painful bone mass, often in the femur. Risk factors include radiation exposure and surviving other cancers like retinoblastoma. Diagnosis involves clinical exams, radiology like X-rays showing lytic or sclerotic lesions, and biopsy showing malignant osteoid and spindle cells. Early metastasis is common.

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    21 views19 pages

    Osteosarcoma

    Uploaded by

    Angga Eka
    Osteosarcoma is a malignant bone cancer that arises from primitive bone cells. It is most common in people ages 12-25 and forms a painful bone mass, often in the femur. Risk factors include radiation exposure and surviving other cancers like retinoblastoma. Diagnosis involves clinical exams, radiology like X-rays showing lytic or sclerotic lesions, and biopsy showing malignant osteoid and spindle cells. Early metastasis is common.

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    © All Rights Reserved
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    of 19

    Osteosarcoma

    Osteosarcoma

    01/14/16

    Definition
    Osteosarcoma is an aggressive malignant
    neoplasm arising from primitive transformed
    cells of mesenchymal origin (and thus a
    sarcoma) that exhibit osteoblastic
    differentiation and produce malignant osteoid.
    It is the most common histological form of
    primary bone cancer in age 12-25yrs.
    3

    Epidemiology

    Male more than female


    at any age but
    75% of cases appear at age 12-25yrs

    Risk factors:
    Radiation exposure
    Patients who survive after taking therapy for
    another Cancer.
    Retinoblastoma(malignant tumor arising from
    retina of eye).
    5

    Sites of predlection:
    Osteosarcoma :It originates more frequently
    in the metaphyseal region of tubular long
    bones, with 42% occurring in the femur

    Skeletal distribution : most


    common at Knee region

    osteosarcoma

    Histopathologic variants
    1. Conventional: osteoblastic, chondroblastic, fibroblastic
    2. Multifocal
    3. Telangiectatic
    4. Small cell
    5. Intraosseous well-differentiated
    6. Intracortical
    7. Periosteal
    8. Paraosteal
    9. High-grade surface
    10. Extraosseous
    9

    Diagnosis of osteosarcoma
    Clinical examiation
    Radiologic examinatiom
    Biopsy for histopathology

    10

    Clinical Presentation
    Painful mass arising from bone
    Metastasize early

    11

    Plain Xray
    The area of tumor mass may be Lytic,
    sclerotic or mixed

    12

    In x ray we can see Codman triangle

    Codman triangle is a term used to describe


    the triangular area of new subperiosteal
    bone that is created when a lesion, often a
    tumour, raises the periosteum away from the
    bone.
    sun-burst" appearance on X-ray
    examination due to the tumor spicules of
    calcified bone radiating in right angles
    13

    Codman triangle

    14

    Codman triangle

    15

    Local
    CT
    MRI
    +/- Angiogram

    16

    Systemic
    Bone scan
    CT Chest

    17

    Osteosarcoma :
    it is formed of Spindle shaped cells showing malignant criteria in form
    of pleomorphism,hyperchromasia, abnormal mitosis, giant cells . In
    between spindle cells there is malignant osteoid.

    18

    Differential Dx
    Giant Cell Tumor
    Aneursymal Bone Cyst
    Ewings tumor
    Osteoblastoma
    Metastasis
    Lymphoma

    19

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