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EXAMINATION
Ashwin Shrivastava

213608633

MATH 6641 SURVIVAL ANALYSIS

A1. (a)
Weibull is the most appropriate, as exponential will assume a constant hazard
model which is not true in this case.

Akaike's Information Criterion for Weibull is 97.4 and for lognormal is 99.6
respectively, hence Weibull is better.

(b)
H 0 : 0 = 1
H 1 : 0 1
Where treatment group and control group are following exponential with 0 and 1 respectively.
Now,
n1=n2=21
r1=9, r2=21
r1

xi

=109

i=1

n1

i=r 1+1

xi

=250

r2

yi

=182

i=1

n2

i=r 2+1

yi

=0.

t0 =39.889
t1 =8.667
Hence,
For

t0
t1 =4.602 with (18,42) degrees of freedom.

=0.05, F18,42,(0.05)=1.855, which is smaller than 4.602, so we reject H 0 at 5%

level.
Therefore, the treatment is more effective.

(c) Performed the Gehan Wilcoxon Test in excel

Since the z-value is significant at 95% confidence, we can say that the treatment is
effective.

A2. (c)1. Least Squared analysis were done in excel and betas were estimated.

At 95% confidence level, we can see that only 1 is significant, i.e. log of a blood
urea nitrogen measurement at diagnosis, and rest are insignificant. If we take it at
90% confidence then haemoglobin and serum calcium measurement at diagnosis
become significant. The beta estimate means in the change in log failure time, for
example, if log of blood urea nitrogen measurement increases by 1 unit than log of
failure time decreases by 1.6 units. Also, 4 is a character factor, i.e. either male or
female. As per the result the female, with all other factors taken at constant, is
-0.0993 has less log of failure time than males.

2. Maximum Likelihood Estimate

1
1.4

2
10.2

3
60.2

4
0.41

5
10.1

3. I would prefer the least squared method as R square of that is higher than
maximum likelihood estimate.