TOPIC

Flunarizine for migraine

prophylaxis

CONTENT
v Indications
v Pharmacokinetic properties
v Mechanism of action
v Contra-indications
v Adverse effects
v Interactions

INDICATIONS
v Prophylaxis of migraine
v Symptomatic treatment of dizziness
v (Peripheral vascular disease)
v (Alternating hemiplegia)
v (Epilepsy adjuvant)

PHARMACOKINETIC
PROPERTIES
vAbsorption
vMetabolism
vElimination
vHalf life

MECHANISM OF
ACTION
vBy acting onvascular smooth muscle
vBy acting on cardiac muscles
vBy slowing down the conduction of electrical
activity within the heart
vBy blocking the calcium signal on adrenal
cortex cells

CONTRAINDICATIONS
vHypotension
vheart failure
vArrhythmia
vDepression
vsevereconstipation
vextrapyramidaldisorders.
v

ADVERSE EFFECTS
v Weight gain
v Sedation
v Depression
v extrapyramidal effects
v Headache/insomnia/asthenia/GI

INTERACTIONS
v Alcohol
v Hypnotics /tranquilizers
v Anticholinergics
v Anticonvulsants