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  • Pattern of Antinuclear Antibody Staining: Diffuse (Homogeneous) Speckled

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    naeem2009
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    Antinuclear antibodies can produce different staining patterns on cell nuclei including diffuse, speckled, peripheral, nucleolar, and centromere. Diffuse staining is associated with systemic lupus erythematosus and drug-induced lupus. Speckled staining correlates with Sjögren's syndrome, systemic lupus erythematosus, and mixed connective tissue disease. Centromere staining links to limited cutaneous systemic sclerosis.

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    Antinuclear antibodies can produce different staining patterns on cell nuclei including diffuse, speckled, peripheral, nucleolar, and centromere. Diffuse staining is associated with systemic lupus erythematosus and drug-induced lupus. Speckled staining correlates with Sjögren's syndrome, systemic lupus erythematosus, and mixed connective tissue disease. Centromere staining links to limited cutaneous systemic sclerosis.

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    23 views1 page

    Pattern of Antinuclear Antibody Staining: Diffuse (Homogeneous) Speckled

    Uploaded by

    naeem2009
    Antinuclear antibodies can produce different staining patterns on cell nuclei including diffuse, speckled, peripheral, nucleolar, and centromere. Diffuse staining is associated with systemic lupus erythematosus and drug-induced lupus. Speckled staining correlates with Sjögren's syndrome, systemic lupus erythematosus, and mixed connective tissue disease. Centromere staining links to limited cutaneous systemic sclerosis.

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    © All Rights Reserved
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    of 1

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    Pattern of antinuclear antibody


    staining
    Pattern
    Diffuse
    (homogeneous)
    Speckled

    Peripheral
    Nucleolar
    Centromere

    Antibodies
    Clinical significance
    directed against
    Systemic lupus erythematosus, drug
    Nucleosomes
    induced lupus, rheumatoid arthritis
    Sjgrens syndrome, systemic lupus
    Sm, ribonuclear
    erythematosus, mixed connective
    protein (RNP), Ro,
    tissue disease, diffuse systemic
    and La
    sclerosis
    Double stranded
    Systemic lupus erythematosus,
    DNA
    autoimmune hepatitis
    Nucleolar RNA
    Diffuse systemic sclerosis
    Centromere
    Limited cutaneous systemic sclerosis

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