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Diphenybutyl
Pimozide 2 -10
Mechanism of action:
Typical neuroleptics are so called because
of their ability to induce catalepsy and to inhibit the
effects of amphetamine, the drug known to
enhance the release of dopamine and cause
extrapyramidal side effect.
Side effects:
Neurological
Parkinsonism
Akathesia
Dystonia
Tardive Dyskinesia
Neuroleptic malignant syndrome (NMS)
Epileptogenic effects.
Cardiovascular side effects:
Orthostatic hypotension
Dizziness
Fainting
Haematological:
Agramulocytosis
Neutropenia
Aplastic anaemia
Dermatological Effects:
Allergic skin reactions
Photosensitivity reactions
Pigmentary changes
Hepatic effects:
Jaundice
Liver function alteration
Atypical Antipsychotics
Effective antipsychotics without producing
undesirable extrapyroamidal side effects.
Antipsychotic without neuroleptic effect.
Selective lymbic dopamium blockade, D4 receptor
blockade
Drugs:
Clozapine 200 – 400mg / day
Resperidone 2 – 16mg / day
Ziprasidone 40 – 160mg / day
Olanzapine 5 – 20mg / day
Quetiapine 150 – 750mg / day
Aripiprazole 15 – 30mg / day
Side Effects:
Clozapine - Agranulocytosis
Seizures
Hypotension
Resperidone - Insomnia
Agitation
Dizziness
Rhinits
Low EPS