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  • Ras Warmoadgens Molekuluri Diagnostika?

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    Tamar Tsertsvadze
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    Molekuluri diagnostika provides concise molecular analysis methods that can help precisely diagnose patients. It analyzes gene and protein expression patterns to detect diseases early and track molecular mechanisms. Techniques like genomics study gene variations, while proteomics analyzes all protein expressions. DNA microarrays can test 10,000 genes at once. Molecular diagnostics is improving treatment by personalizing it based on individual molecular factors.

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    MolecDiagn_1Fin

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    Molekuluri diagnostika provides concise molecular analysis methods that can help precisely diagnose patients. It analyzes gene and protein expression patterns to detect diseases early and track molecular mechanisms. Techniques like genomics study gene variations, while proteomics analyzes all protein expressions. DNA microarrays can test 10,000 genes at once. Molecular diagnostics is improving treatment by personalizing it based on individual molecular factors.

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    23 views13 pages

    Ras Warmoadgens Molekuluri Diagnostika?

    Uploaded by

    Tamar Tsertsvadze
    Molekuluri diagnostika provides concise molecular analysis methods that can help precisely diagnose patients. It analyzes gene and protein expression patterns to detect diseases early and track molecular mechanisms. Techniques like genomics study gene variations, while proteomics analyzes all protein expressions. DNA microarrays can test 10,000 genes at once. Molecular diagnostics is improving treatment by personalizing it based on individual molecular factors.

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    of 13

    leqcia 1

    ras warmoadgens molekuluri


    diagnostika?
    molekuluri diagnostika

    • medicinis “individualizacia”:

    calkeuli pacientisTvis daavadebis molekuluri meqanizmebis


    garkveva

    • gamoiyenaba genebis an cilebis aqtiurobis “suraTebi”


    (“patterns”)
    molekuluri diagnostika

    • ZiriTadad gamoiyeneba kibos deteqciis da


    diagnostirebisaTvis
    • efuZneba or axal disciplinas: “genomikss” da
    “proteomikss”
    • genomiksi swavlobs genebis mTel erTobliobas ujredSi
    • proteomiksi – yvela cilis erTobliobas
    molekuluri diagnostika

    dnm Cipi Seicavs 10.000 an met “wveTs” (spot)


    molekuluri diagnostika
    molekuluri diagnostika
    molekuluri diagnostika

    dnaarray.exe
    dnm Cipebis gamoyenebis magaliTebi

    kuWis simsivnis qsovilSi – eqspresirebulia geni PLA2G2A


    kuWis normalur qsovilSi aRniSnuli geni eqspresirebuli ar aris
    pacientebs PLA2G2A genis maRali eqspresiiT ukeTesi prognozi gaaCniaT

    mkerdis kibos SemTxvevaSi 25000 genidan gamoiyo 17, romlebic


    ganapiroben qalTa 90%-Si metastazebis ganviTarebis albaTobas

    adamianTa 40%-s SNP gaaCnia , romelic citoqrom P450 CYP2C9s deficits,


    rac arsebuli wamebidan 5-dan 1-is metabolizms aferxebs!
    molekuluri diagnostika: proteomiksi
    molekuluri diagnostika: proteomiksi
    leqciebi:
    I nawili. dnm-is analizis meTodebi

    leqcia 1. Sesavali. Ras warmoadens Tanamedrove molekuluri diagnostika?

    leqcia 2. dnm-is eqstraqcia. dnm-is restriqciuli analizi.

    leqcia 3. dnm-eleqtroforezi gelSi, sadiagnostiko mniSvneloba. meTodis gamoyeneba


    sadiagnostiko amocanebisaTvis.

    leqcia 4. dnm-hibridizacia. Southern bloTingi. In situ dnm-hibridizacia.

    leqcia 5. polimerazuli jaWvuri reaqcia (PCR): principi, variantebi, gamoyeneba klinikuri


    gamokvlevebisTvis.

    leqcia 6. dnm-is aminomJavuri Tanmimdevrobebis dadgena: zogadi principebi. dnm-ruqebis


    Sedgena.

    leqcia 7. mutaciuri analizi. genuri mikroCipebis teqnologia, maTi gamoyeneba klinikur


    diagnostikaSi.

    leqcia 8. I sakontrolo wera (maqsimaluri qula - 51)


    II. a) rnm-is analizis meTodebi b) cilebis analizis meTodebi

    leqcia 9. rnm-is eqstraqcia. Northern bloTingi. Misi sadiagnostiko mniSvneloba.

    leqcia 10. RT-PCR: principebi, gamoyeneba daavadebaTa diagnostikisaTvis.

    leqcia 11. cilis eqstraqcia. SDS-PAGE. 2D-eleqtroforezis meTodi.

    leqcia 12. Western bloTingis meTodi.

    leqcia 13. Genebis transkrifciis meTodebi da cilis eqspresia sxvadasxva sistemebSi.

    leqcia 14. klinikuri proteomiksi.

    leqcia 15. II sakontrolo wera (maqsimaluri qula - 15)


    Sefaseba:
    • daswreba –10 %
    (5% seminarze/praqtikulze, 5% leqciaze)
    • sakontrolo wera (2) (sul 30%)
    • aqtivoba seminaris/praqtikulis dros (10%)
    • gamocda (40%)

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