Nanomedicine

The Initiative
With the script ,following each slide

Alexandria Faculty of Medicine

Nanomedicine student group

Medicine Panel

Nanomedicine student group

Nanomedicine
The Initiative

Alexandria Faculty of Medicine

Nanomedicine student group

Medicine Panel Co.

Nanomedicine student group

 Slide 1
• Good morning, My name is Momen Zalabany
i’m a member of nano student group, and i’m
honored to give this opening presentation of
this congress in which we will begin with a short
briefing on nanotechnology and nanomedicine.
Followed by some information on the current
status of this field. Then I will be discussing the
prospect of initiating this science in our faculty
which will be our main topic in this paper
Nanotechnology
Definition
Nanotechnology is defined as Research and technology development at the
atomic, molecular and macromolecular levels

Generally nanotechnology deals with structures sized between

1 to 100 nanometer.
Nano Scale
Nanometer = 1/1,000,000 mm
Prefix Nano means “Dwarfs”

Momen zalabany Nanomedicine

 Slide 2
• Starting with defining nanotechnology, there has been a great confusion
among scientist around the exact definition of nanotechnology, however, it is
to be noticed that different institutions start their process by defining
nanotechnology in a way that is most relevant to their research purposes.
• NNI defined nanotechnology “Nanotechnology is defined as Research and
technology development at the atomic, molecular and macromolecular levels,
to create structures, devices, and systems that have novel functional
properties”.
• The prefix “Nano” is derived from a Greek origne which means “Dwarf” .
Which is mathematicly equal to 1mil of mm, to imagine this we can say that
the human hair diameter = 100,000 nm

• From the graph below we can that the area of interest is between 1-100 nm ,
which is equvilent to glucose molecule up to size of a viruse
Nanotechnology
History

1959 R.feyman
There's Plenty of Room at the Bottom

1977 Drexler
Building machines on the scale of molecules

1981 STM invention followed by AFM

1986

Momen zalabany Nanomedicine

 Slide 3
• To undersan more we can fist look at History of nanotechnolgy
• It has been accounted that nanotechnology began with Prof. Richard
Feynman historical speech in 1959 titled “There’s plenty of room at the
bottom” in which he outlined that there is nothing in physics that stands
against the manipulation of matter atom by atom to build up bigger objects
from the bottom up tailored to specific needs .
•  
• And then in 1977 when Prof. Eric Drexler originates concept of molecular
nanotechnology at MIT “building machines on the scale of molecules,”
• But it wasn’t until the mid 1980’s that these words began to materialize with
the invention of the Scanning and tunnelling microscope followed by the
Atomic force microscope which gave scientist a resolution of power with of
0.1 nm lateral resolution and 0.01 nm depth, and also gave the ability to
manipulate atoms.
Natural Development

Micro
Min
iatu
r iza
tio n

Nano Biology

i t y
le x
m p
c o
la r
ec u
o l
Atomic M
1950 2000 2050
AFM invention

Momen Zalabany Nanomedicine

 Slide 4
• Operating on the nanoscale includes Miniaturization of the micro scale and molecular
complexity of atomic scale and hopefully they can both intersect to give us better
understating and control over biology
• As we notice any science developing course we notice a constant and common thread
which is As life science develops, our level of control and interaction increases in depth
and become more precise by being able to study analyze and produce at smaller size
For example With the invention the light microscope an entire life science has been
radically changed over the following years

• The common pattern between microbiology and nanomedicine is that nanomedicine

has also been changed radically after the AFM which gives us a hint over the amount of
developing a head of us

• Generally speaking biology science is heading toward solving molecular complexity on

level of atoms
Conclusion

Nanotechnology is a size-based science

“Nano” as a prefix means size <100nm

is an umbrella term used to define the products, processes and properties at

the nanoscale that is of structures less than 100nm (less than a virus size)

Any advance in nanotechnology will be based on

Nanomaterials advances

Nanomedicine
 Slide 5
• To sum it up Nanotechnology is a size-based
science field which can be summarized as an
umbrella term used to define the products,
processes and properties at the nanoscale
that is of structures less than 100nm (less than
a virus size)
Nanomedicine
The ESF Definition

“ The science and technology of diagnosing,

treating and preventing disease and traumatic
injury, of relieving pain, and of preserving and
improving human health, using molecular tools
and molecular knowledge of the human body.”

Momen Zalabany Nanomedicine

 Slide 6
• Now switching the talk to nanomedicine, the European
science foundation defines Nanomedicine as “The science
and technology of diagnosing, treating and preventing
disease and traumatic injury, of relieving pain, and of
preserving and improving human health, using molecular
tools and molecular knowledge of the human body.” From
which we can conclude that Nanotechnology is the broad
scientific field that encompasses nanomedicine In which it
mainly serves to  advance the safe and effective use of
nanotechnologies to reduce death and suffering from
human disease
Potential

It exploits the improved and often novel

physical, chemical and biological properties of
materials at the nanometer scale.

Analytical tools

Nano Imaging

Nanomaterials and devices

Drug delivery systems and therapeutics

Momen Zalabany Nanomedicine

 Slide 7
• talk about potential can take lots of time and it will
be further discussed later on today, but in short
• Potential of nanomedicine is to provide better
healthcare throu 4 main categorize which are
• analytical tools,imaging,nanomaterial and
devices,DDS and novel therapeutics,
• as we speak there are current product the have
already reached market which are nanomedicine
based . As we can see in next slide
Current status And Potential

Doxil Liposomal Daunoribicin

Daunoxome Liposomal Doxorubicin
Cancer Herceptin (her2) Monoclonal AB HER2 inherent activity
Abraxan(breast) Albumin n.p. paclitaxel

Zinostatin stimalmer
Polymer SMANCS
Liver disease PEG family
Detoxification Var.

Ambisome Liposomal Amphotericin B

Virology , Vivagel Dendrimer-based SPL7013

Endorem Super-para-mag. Iron

Imaging MRI Gadomer Dendrimer-based Gad.

Momen Zalabany Nanomedicine

 Slide 8
• As you can see, this is a short list of some product in the market that are
nanomedicine based for example in
• Caner : there is Doxil which is a liposomal based drug carrier with payload
of danuoribince
• As for liver disease: pegylated family of drugs (eg. Peg-interferon) which is
based on detoxifying nanotool (peg)
• Vivagel is a new topical Hiv drug which is a dendretic based drug.
• as for imaging MRI enhancement : there is already (Endorem and gadomer)
which are based on iron supermagnitism and dendrim carrier respectively

• For more information on the principles on which these drugs are based you
can referred to our last year presentation in which we discussed these
principles in details.
Nanomedicine Roadmap

The need for a nanomedicine initiative

The Faculty Role

Action plan

Momen Zalabany Nanomedicine

 Slide 9
• Now coming to the main topic of our
presentation which is road map to
nanomedicine , we will be discussing the need
for a nanomedicine initiative and our faculty
role towards it and the plan to set it in action
Nanomedicine Roadmap
The need for a nanomedicine initiative
Why we need to start now?!!!

Taking the lead and putting corner stone in

Africa
oHuman Resources
oDeveloping statues
oHuge medical needs
oEgypt ruling model

2000 2010 2020

1990

Momen Zalabany Nanomedicine

 Slide 10.main
• Generaly owning to the fact that nanomedicine is a newly rising science the window is still open for developing countries to
pursue .

• the coming years hold a huge hope for Africa, we think that start of something big could take place now, specialy that we have
factors that can help us doing so
For example

• Human resource huge diversity with abundant resources, the candidate in Africa is of high potential yet healthcare cost are much
lower than many other countries

• Since african development is on the rise and and the general attitude is towords opening to research , it is belived that this
scientific field would be easy to implement

• It’s widly known that africa carries the largest medical need around the world and already carries the most spending in healthcare
aid origanizations like the WHO, which will also present a huge opertunity to induce a noticable change with minute advances

• Finally egypt has the leading resources and optimum scientific vantages to take the lead since we are already took our first steps

• So to set this in action there is a number of intiaition factors that need to be supplied and some stratgies that need to be followed
,
 Slide 10.end
So to set this in action there is a number of
initiation factors that need to be supplied and
some strategies that need to be followed ,
Nanomedicine Roadmap
Initiation

Construct lab and needed tools

Facility •Facility is similar to Basic molecular biology lab
•AFM as corner stone for characterization of nanoparticles
•Other tools mainly depends on our research field
●
Place
●
Tools

Setup of Research plan

●
Need oriented plan

Expertise
●
of Different Experiences as medicine, physics and chemistry

Provide core Scientific training

Funding
●
Establishing a stable funding resource

Partnership
●
True Goal oriented partnerships

Momen Zalabany Nanomedicine

 Slide 11
The vision of our student groups highly suggests
that that the following factors are required to
bring this science one step closer which are
(listed below)
, and now we will discuss each element in detail
to clarify exactly what we mean.
 Slide 11+
• Generally, the facility would be very similar in composition
to a molecular biology research facility, with one prominent
difference that is the need for Atomic force microscope for
the sake of characterizing the nanoparticles, although this
technology does not have to be exclusive to the uses of the
nanomedicine facility, what is really required is frequent
access to the AFM to be able to characterize the particles
sensitized, which does not happens on very shot intervals.
• Other than that, different elements of facility will depend
on the nature of the onging research, which bring us to the
research plan
Nanomedicine Roadmap
Initiation

Need oriented research plan

Medical Aspect Physics and chemistry

Disease Aimed function Method or Nanomaterials

phenomena
• Tio2
• Liver disease • Diagnosis
• Pick up from
different
• Cancer • Treatment principles • Gold

• Parasitic • Commercial • Iron

diseases products
• Silicon
• Neurological
disease

Momen Zalabany Nanomedicine

 Slide 12
• Our vision for the research plan is of a multidisciplinary approach,
in which the efforts of researchers in medicine physics and
chemistry are required.
• As we see we start by defining unmet disease priorities , as you
can see on the top of the (list), next step will be to conclude the
required function to tackle these diseases such as Dx, Rx.
• Following with aid from physics and chemistry researchs they can
help us desigining our expermints and decided on nanomaterial
and phenomina that can help us achieve the function
• For example iron and silicon nanoparticls can be recommended for
diagnosis functions due to there unique phenomena that allow
them to be the best candidate for imaging enhancement
Nanomedicine Roadmap

Scientific training

Undergraduates Graduates Informatics

molecular biology New programs for early graduate Developers

Colloidal chemistry More M.D./PhD programs

membrane biophysics
Communication

Computational science

Life sciences

Momen Zalabany Nanomedicine

 Slide 13a
• Providing core scientific training is an essential
piece of the puzzle ,
• Which can be details as the Key of success of
any lab depends mainly on the scientist core
working within, and so providing a core
scientific training for physicians and
researchers would be essential to ensure a
working force that can match the rapid
development in this field.
 Slide 13b
• And so in term of education, we need to introduce
undergraduates to the basic sciences used in
nanomedicine.
• That includes orientation of undergraduates with the
basics of (items) in addition to their ongoing life science
study, to increase the awareness of the field and allow
interested undergraduates to pursue a career in research.
• Graduates students can tempted to research thru the
availability of programs for fresh graduates and more
Md/PhD programs.
 Slide 13c
• Owned to the fact that nanomedicine field is a newly rising science,
the need for skilled personals in field of medical informatics is
essential both to provide aid in computational science and to try to
overcome the problem of communications –which is a universal
challenge up till now- thru utilization of modern technologies and
construction of an international library that can help synchronize the
work between goal-oriented research partners in large medical
centers and universities research groups, also its good to mention
that that any development in the field on nanomedicine is based
on the development of nonmaterial’s (since it’s the precursor for
any nanotool or device) , and so communication and building a
library for new developments in nonmaterial is essential for the
nanomedicine development.
Nanomedicine Roadmap
Initiation

Funding
●
Establishing funding resources

•Public orientation
•Grants
•Investors
•Fund raising projects

Nanomedicine
 Slide 14
• The prospect of funding can be seriuos issue in
africa however there are a few angles that can
asssit in this matter such as .
• Increasing public and government awarness and
orintation which will be discussed later.
• Applying for grants , tempting investors to invest in
nanomedicine , and fund raising projects that can
be in the form of the production of commercial
products that can be used to fun a parallel research
Nanomedicine Roadmap
Action plan
Public orientation
Government support

By informing the government of ongoing research and its potential to decrease

morbidity and therefore can reduce health care costs over the long term which encourage
them to include this research in government budgeting

And Informing the public through awareness programs that can help them
understand the difference between the facts that should by supported and fiction that should
be neglected

Nanomedicine
 Slide 15
• At any stage of our lab , politicians need to be briefed with the
work of the lab, noting that such field will not only provide better
treatment, D but also there will be many commercial benefits by
decreasing the expenses of treatment and decreasing morbidity,
such brief is essential so we can convince dissen makers to
allocate a budget and funds for research and also to keep all
parties –including the public - oriented with the ongoing research

•this will not happens unless we can provide balanced

information about nanomedicine to differentiate between what is
Facts that should be supported and fiction that should we neglect.
Nanomedicine Roadmap
Initiation

Partnership
●
Establish a True Goal-oriented partnerships

Exchange experiences
Design experiments and split roles

Nanomedicine
 Slide 16
• Establishing true goal oriented partnerships to
exchange experiences and to assist in
experimental design and perhaps partnering
until our facility has enough expertise to
operate on its own, although sharing
experiences and results would still be in effect.
 And that’s it !!

Questions please?

Presented by:
Momen Zalabany
Nanomedicine Research Group

Nanomedicine
 Slide 17
• And thats all about this presentaion, this was
our visoin of our student group, thank you for
your time and attention ,

• An now if anyone have any question